WormBase Tree Display for Expression_cluster: WBPaper00041002:HF_3d_2.0mM_Down

WBPaper00041002:HF_3d_2.0mM_Down Description: Gene significantly down-regulated by treatment with 2.0mM of HuminFeed until young adult stage (3 days), with a minimum fold change in gene expression of 0.8.
  Species: Caenorhabditis elegans
  Algorithm: For selection of DEGs, an unpaired t -test was performed followed by a significance analysis of microarray (SAM) test including a calculation that estimates the false discovery rate (FDR). FDR, reducing on the one hand type I errors for null associations, was set to a non-stringent level of <12.5%, mainly to guard from an increase of type II error and also based on findings by Levine et al. (2011), which described 12.5% as most acceptable optimum level of FDR, representing the 90th percentile of the normal distribution curve. DEGs exceeding a fold change of 1.25 were further analyzed with respect to their functional clustering. This fold-cut-off was chosen to allow an interpretation that is biologically meaningful, akin to the notion that data of sound technical and experimental quality which returns strong, statistically significant, absolute signal intensities is sufficiently robust to justify a fold-cut-off of >1.2. This analysis was conducted using the functional annotation clustering tool of the Database for Annotation, Visualization, and Integrated Discovery (DAVID; Huang et al., 2007).
  Reference: WBPaper00041002
  Microarray_results: 171919_x_at Fold Change: 0.8, FDR P-value:0.08
    172005_x_at Fold Change: 0.8, FDR P-value:0.05
    172147_x_at Fold Change: 0.8, FDR P-value:0.08
    172242_x_at Fold Change: 0.8, FDR P-value:0.05
    172389_x_at Fold Change: 0.8, FDR P-value:0.08
    172440_x_at Fold Change: 0.8, FDR P-value:0.08
    172515_x_at Fold Change: 0.8, FDR P-value:0.08
    172536_x_at Fold Change: 0.8, FDR P-value:0.08
    172628_x_at Fold Change: 0.8, FDR P-value:0.08
    172642_s_at Fold Change: 0.8, FDR P-value:0.08
    172741_x_at Fold Change: 0.8, FDR P-value:0.08
    172856_x_at Fold Change: 0.8, FDR P-value:0.08
    172961_x_at Fold Change: 0.8, FDR P-value:0.05
    173070_s_at Fold Change: 0.8, FDR P-value:0.08
    173079_s_at Fold Change: 0.8, FDR P-value:0.08
    173165_s_at Fold Change: 0.8, FDR P-value:0.08
    173328_s_at Fold Change: 0.8, FDR P-value:0.08
    173364_s_at Fold Change: 0.8, FDR P-value:0.08
    173452_s_at Fold Change: 0.8, FDR P-value:0.08
    173689_s_at Fold Change: 0.8, FDR P-value:0.05
    173715_s_at Fold Change: 0.8, FDR P-value:0.05
    173866_s_at Fold Change: 0.8, FDR P-value:0.08
    174026_at Fold Change: 0.8, FDR P-value:0.08
    174069_at Fold Change: 0.8, FDR P-value:0.05
    174199_at Fold Change: 0.8, FDR P-value:0.08
    174531_at Fold Change: 0.8, FDR P-value:0.08
    174543_at Fold Change: 0.8, FDR P-value:0.08
    174599_at Fold Change: 0.8, FDR P-value:0.07
    174638_at Fold Change: 0.8, FDR P-value:0.08
    174662_at Fold Change: 0.8, FDR P-value:0.08
    174667_at Fold Change: 0.8, FDR P-value:0.08
    175032_at Fold Change: 0.8, FDR P-value:0.08
    175219_s_at Fold Change: 0.8, FDR P-value:0.08
    175227_s_at Fold Change: 0.8, FDR P-value:0.08
    175570_at Fold Change: 0.8, FDR P-value:0.07
    175648_at Fold Change: 0.8, FDR P-value:0.07
    175677_s_at Fold Change: 0.8, FDR P-value:0.07
    175678_at Fold Change: 0.8, FDR P-value:0.08
    175981_at Fold Change: 0.8, FDR P-value:0.08
    176044_at Fold Change: 0.8, FDR P-value:0.07
    176059_at Fold Change: 0.8, FDR P-value:0.08
    176250_s_at Fold Change: 0.8, FDR P-value:0.08
    176981_s_at Fold Change: 0.8, FDR P-value:0.07
    177038_at Fold Change: 0.8, FDR P-value:0.08
    177053_at Fold Change: 0.8, FDR P-value:0.08
    177081_at Fold Change: 0.8, FDR P-value:0.08
    177104_at Fold Change: 0.8, FDR P-value:0.08
    177600_at Fold Change: 0.8, FDR P-value:0.05
    177706_at Fold Change: 0.8, FDR P-value:0.08
    177974_s_at Fold Change: 0.8, FDR P-value:0.08
    177987_at Fold Change: 0.8, FDR P-value:0.08
    178017_s_at Fold Change: 0.8, FDR P-value:0.08
    178387_at Fold Change: 0.8, FDR P-value:0.08
    178409_s_at Fold Change: 0.8, FDR P-value:0.08
    178523_at Fold Change: 0.8, FDR P-value:0.08
    178792_at Fold Change: 0.8, FDR P-value:0.08
    178834_at Fold Change: 0.8, FDR P-value:0.07
    178963_at Fold Change: 0.8, FDR P-value:0.07
    179430_s_at Fold Change: 0.8, FDR P-value:0.08
    179796_at Fold Change: 0.8, FDR P-value:0.08
    179939_at Fold Change: 0.8, FDR P-value:0.08
    180042_at Fold Change: 0.8, FDR P-value:0.08
    180070_s_at Fold Change: 0.8, FDR P-value:0.07
    180223_s_at Fold Change: 0.8, FDR P-value:0.08
    180594_at Fold Change: 0.8, FDR P-value:0.07
    180632_at Fold Change: 0.8, FDR P-value:0.08
    180933_at Fold Change: 0.8, FDR P-value:0.08
    181243_at Fold Change: 0.8, FDR P-value:0.08
    181735_at Fold Change: 0.8, FDR P-value:0.05
    181941_s_at Fold Change: 0.8, FDR P-value:0.08
    181976_at Fold Change: 0.8, FDR P-value:0.08
    182079_at Fold Change: 0.8, FDR P-value:0.07
    182089_at Fold Change: 0.8, FDR P-value:0.08
    182123_at Fold Change: 0.8, FDR P-value:0.05
    182219_at Fold Change: 0.8, FDR P-value:0.08
    182391_at Fold Change: 0.8, FDR P-value:0.08
    182517_at Fold Change: 0.8, FDR P-value:0.08
    182663_at Fold Change: 0.8, FDR P-value:0.05
    183250_at Fold Change: 0.8, FDR P-value:0.08
    183333_at Fold Change: 0.8, FDR P-value:0.08
    183620_at Fold Change: 0.8, FDR P-value:0.07
    183707_s_at Fold Change: 0.8, FDR P-value:0.08
    183864_s_at Fold Change: 0.8, FDR P-value:0.07
    183877_s_at Fold Change: 0.8, FDR P-value:0.08
    183967_at Fold Change: 0.8, FDR P-value:0.08
    184042_at Fold Change: 0.8, FDR P-value:0.08
    184142_s_at Fold Change: 0.8, FDR P-value:0.08
    184203_at Fold Change: 0.8, FDR P-value:0.08
    184227_at Fold Change: 0.8, FDR P-value:0.08
    184269_at Fold Change: 0.8, FDR P-value:0.08
    184274_at Fold Change: 0.8, FDR P-value:0.07
    184481_at Fold Change: 0.8, FDR P-value:0.08
    184711_at Fold Change: 0.8, FDR P-value:0.08
    184947_s_at Fold Change: 0.8, FDR P-value:0.05
    185007_s_at Fold Change: 0.8, FDR P-value:0.05
    185035_s_at Fold Change: 0.8, FDR P-value:0.08
    185452_at Fold Change: 0.8, FDR P-value:0.08
    185557_s_at Fold Change: 0.8, FDR P-value:0.05
    185669_at Fold Change: 0.8, FDR P-value:0.08
    185790_at Fold Change: 0.8, FDR P-value:0.07
    186010_at Fold Change: 0.8, FDR P-value:0.08
    186389_at Fold Change: 0.8, FDR P-value:0.08
    186498_s_at Fold Change: 0.8, FDR P-value:0.05
    186586_at Fold Change: 0.8, FDR P-value:0.07
    186595_s_at Fold Change: 0.8, FDR P-value:0.08
    186766_at Fold Change: 0.8, FDR P-value:0.08
    187309_at Fold Change: 0.8, FDR P-value:0.08
    187346_at Fold Change: 0.8, FDR P-value:0.08
    187369_s_at Fold Change: 0.8, FDR P-value:0.08
    187385_s_at Fold Change: 0.8, FDR P-value:0.05
    187429_s_at Fold Change: 0.8, FDR P-value:0.08
    187470_s_at Fold Change: 0.8, FDR P-value:0.07
    187477_s_at Fold Change: 0.8, FDR P-value:0.05
    187534_s_at Fold Change: 0.8, FDR P-value:0.08
    187554_at Fold Change: 0.8, FDR P-value:0.07
    187590_at Fold Change: 0.8, FDR P-value:0.08
    187781_s_at Fold Change: 0.8, FDR P-value:0.08
    187838_s_at Fold Change: 0.8, FDR P-value:0.08
    188033_s_at Fold Change: 0.8, FDR P-value:0.08
    188047_at Fold Change: 0.8, FDR P-value:0.07
    188052_s_at Fold Change: 0.8, FDR P-value:0.08
    188102_s_at Fold Change: 0.8, FDR P-value:0.05
    188157_at Fold Change: 0.8, FDR P-value:0.08
    188174_s_at Fold Change: 0.8, FDR P-value:0.08
    188271_at Fold Change: 0.8, FDR P-value:0.08
    188414_at Fold Change: 0.8, FDR P-value:0.08
    188620_s_at Fold Change: 0.8, FDR P-value:0.07
    188634_s_at Fold Change: 0.8, FDR P-value:0.07
    188964_at Fold Change: 0.8, FDR P-value:0.08
    189365_s_at Fold Change: 0.8, FDR P-value:0.08
    189462_s_at Fold Change: 0.8, FDR P-value:0.08
    189641_at Fold Change: 0.8, FDR P-value:0.08
    189848_at Fold Change: 0.8, FDR P-value:0.07
    189907_s_at Fold Change: 0.8, FDR P-value:0.05
    189942_at Fold Change: 0.8, FDR P-value:0.07
    189988_s_at Fold Change: 0.8, FDR P-value:0.08
    190360_s_at Fold Change: 0.8, FDR P-value:0.08
    190456_at Fold Change: 0.8, FDR P-value:0.08
    190457_s_at Fold Change: 0.8, FDR P-value:0.08
    190499_s_at Fold Change: 0.8, FDR P-value:0.08
    190700_s_at Fold Change: 0.8, FDR P-value:0.05
    190715_at Fold Change: 0.8, FDR P-value:0.07
    190888_s_at Fold Change: 0.8, FDR P-value:0.08
    190922_s_at Fold Change: 0.8, FDR P-value:0.08
    191135_s_at Fold Change: 0.8, FDR P-value:0.05
    191368_s_at Fold Change: 0.8, FDR P-value:0.08
    191449_s_at Fold Change: 0.8, FDR P-value:0.08
    191552_s_at Fold Change: 0.8, FDR P-value:0.08
    191634_at Fold Change: 0.8, FDR P-value:0.08
    192259_s_at Fold Change: 0.8, FDR P-value:0.07
    192290_s_at Fold Change: 0.8, FDR P-value:0.08
    192377_at Fold Change: 0.8, FDR P-value:0.08
    192389_at Fold Change: 0.8, FDR P-value:0.08
    192737_at Fold Change: 0.8, FDR P-value:0.08
    192792_at Fold Change: 0.8, FDR P-value:0.08
    192830_s_at Fold Change: 0.8, FDR P-value:0.07
    192897_at Fold Change: 0.8, FDR P-value:0.08
    192931_at Fold Change: 0.8, FDR P-value:0.07
    193036_s_at Fold Change: 0.8, FDR P-value:0.08
    193046_at Fold Change: 0.8, FDR P-value:0.08
    193081_at Fold Change: 0.8, FDR P-value:0.05
    193103_s_at Fold Change: 0.8, FDR P-value:0.08
    193220_s_at Fold Change: 0.8, FDR P-value:0.08
    193313_s_at Fold Change: 0.8, FDR P-value:0.08
    193372_at Fold Change: 0.8, FDR P-value:0.08
    193524_at Fold Change: 0.8, FDR P-value:0.08
    193700_s_at Fold Change: 0.8, FDR P-value:0.05
    193785_s_at Fold Change: 0.8, FDR P-value:0.07
    193824_s_at Fold Change: 0.8, FDR P-value:0.05
    193932_s_at Fold Change: 0.8, FDR P-value:0.08
    194013_s_at Fold Change: 0.8, FDR P-value:0.07
    194169_s_at Fold Change: 0.8, FDR P-value:0.08
    194212_x_at Fold Change: 0.8, FDR P-value:0.08
    171732_x_at Fold Change: 0.7, FDR P-value:0.08
    171755_x_at Fold Change: 0.7, FDR P-value:0.08
    171757_x_at Fold Change: 0.7, FDR P-value:0.08
    171765_x_at Fold Change: 0.7, FDR P-value:0.08
    171806_x_at Fold Change: 0.7, FDR P-value:0.08
    171862_s_at Fold Change: 0.7, FDR P-value:0.08
    171888_x_at Fold Change: 0.7, FDR P-value:0.08
    171939_x_at Fold Change: 0.7, FDR P-value:0.08
    171962_x_at Fold Change: 0.7, FDR P-value:0.08
    171964_s_at Fold Change: 0.7, FDR P-value:0.08
    171974_x_at Fold Change: 0.7, FDR P-value:0.08
    172026_x_at Fold Change: 0.7, FDR P-value:0.05
    172042_x_at Fold Change: 0.7, FDR P-value:0.07
    172160_x_at Fold Change: 0.7, FDR P-value:0.08
    172184_x_at Fold Change: 0.7, FDR P-value:0.08
    172218_x_at Fold Change: 0.7, FDR P-value:0.07
    172238_x_at Fold Change: 0.7, FDR P-value:0.08
    172243_x_at Fold Change: 0.7, FDR P-value:0.08
    172304_x_at Fold Change: 0.7, FDR P-value:0.07
    172467_x_at Fold Change: 0.7, FDR P-value:0.08
    172493_x_at Fold Change: 0.7, FDR P-value:0.08
    172497_x_at Fold Change: 0.7, FDR P-value:0.08
    172506_x_at Fold Change: 0.7, FDR P-value:0.08
    172520_x_at Fold Change: 0.7, FDR P-value:0.08
    172525_x_at Fold Change: 0.7, FDR P-value:0.08
    172547_x_at Fold Change: 0.7, FDR P-value:0.08
    172579_x_at Fold Change: 0.7, FDR P-value:0.08
    172595_x_at Fold Change: 0.7, FDR P-value:0.08
    172610_x_at Fold Change: 0.7, FDR P-value:0.05
    172774_x_at Fold Change: 0.7, FDR P-value:0.08
    172775_x_at Fold Change: 0.7, FDR P-value:0.07
    172845_x_at Fold Change: 0.7, FDR P-value:0.08
    172870_x_at Fold Change: 0.7, FDR P-value:0.08
    172873_x_at Fold Change: 0.7, FDR P-value:0.08
    172877_x_at Fold Change: 0.7, FDR P-value:0.08
    173001_s_at Fold Change: 0.7, FDR P-value:0.08
    173009_s_at Fold Change: 0.7, FDR P-value:0.07
    173014_at Fold Change: 0.7, FDR P-value:0.08
    173021_s_at Fold Change: 0.7, FDR P-value:0.08
    173052_at Fold Change: 0.7, FDR P-value:0.08
    173077_s_at Fold Change: 0.7, FDR P-value:0.08
    173104_at Fold Change: 0.7, FDR P-value:0.08
    173111_s_at Fold Change: 0.7, FDR P-value:0.08
    173145_at Fold Change: 0.7, FDR P-value:0.05
    173183_s_at Fold Change: 0.7, FDR P-value:0.08
    173195_s_at Fold Change: 0.7, FDR P-value:0.07
    173200_s_at Fold Change: 0.7, FDR P-value:0.08
    173211_at Fold Change: 0.7, FDR P-value:0.08
    173227_at Fold Change: 0.7, FDR P-value:0.08
    173260_s_at Fold Change: 0.7, FDR P-value:0.08
    173299_s_at Fold Change: 0.7, FDR P-value:0.05
    173320_s_at Fold Change: 0.7, FDR P-value:0.08
    173324_s_at Fold Change: 0.7, FDR P-value:0.08
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    173342_at Fold Change: 0.7, FDR P-value:0.08
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    173383_s_at Fold Change: 0.7, FDR P-value:0.08
    173384_at Fold Change: 0.7, FDR P-value:0.08
    173386_s_at Fold Change: 0.7, FDR P-value:0.08
    173433_s_at Fold Change: 0.7, FDR P-value:0.08
    173436_at Fold Change: 0.7, FDR P-value:0.08
    173444_s_at Fold Change: 0.7, FDR P-value:0.08
    173470_s_at Fold Change: 0.7, FDR P-value:0.07
    173476_s_at Fold Change: 0.7, FDR P-value:0.08
    173483_s_at Fold Change: 0.7, FDR P-value:0.08
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    173510_s_at Fold Change: 0.7, FDR P-value:0.05
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    173538_s_at Fold Change: 0.7, FDR P-value:0.05
    173562_s_at Fold Change: 0.7, FDR P-value:0.07
    173624_at Fold Change: 0.7, FDR P-value:0.07
    173629_at Fold Change: 0.7, FDR P-value:0.08
    173633_at Fold Change: 0.7, FDR P-value:0.05
    173651_at Fold Change: 0.7, FDR P-value:0.08
    173681_s_at Fold Change: 0.7, FDR P-value:0.08
    173696_at Fold Change: 0.7, FDR P-value:0.08
    173730_at Fold Change: 0.7, FDR P-value:0.08
    173734_at Fold Change: 0.7, FDR P-value:0.08
    173739_at Fold Change: 0.7, FDR P-value:0.05
    173750_at Fold Change: 0.7, FDR P-value:0.05
    173779_at Fold Change: 0.7, FDR P-value:0.08
    173789_at Fold Change: 0.7, FDR P-value:0.07
    173830_at Fold Change: 0.7, FDR P-value:0.07
    173857_at Fold Change: 0.7, FDR P-value:0.08
    173864_at Fold Change: 0.7, FDR P-value:0.05
    173891_s_at Fold Change: 0.7, FDR P-value:0.08
    173901_s_at Fold Change: 0.7, FDR P-value:0.08
    173934_at Fold Change: 0.7, FDR P-value:0.08
    173942_s_at Fold Change: 0.7, FDR P-value:0.05
    173964_s_at Fold Change: 0.7, FDR P-value:0.08
    173976_at Fold Change: 0.7, FDR P-value:0.08
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    174022_at Fold Change: 0.7, FDR P-value:0.08
    174024_at Fold Change: 0.7, FDR P-value:0.08
    174065_at Fold Change: 0.7, FDR P-value:0.08
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    174216_at Fold Change: 0.7, FDR P-value:0.08
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    174350_at Fold Change: 0.7, FDR P-value:0.08
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    174631_at Fold Change: 0.7, FDR P-value:0.08
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    174666_at Fold Change: 0.7, FDR P-value:0.05
    174695_s_at Fold Change: 0.7, FDR P-value:0.08
    174715_at Fold Change: 0.7, FDR P-value:0.05
    174717_at Fold Change: 0.7, FDR P-value:0.08
    174719_at Fold Change: 0.7, FDR P-value:0.08
    174721_at Fold Change: 0.7, FDR P-value:0.07
    174726_at Fold Change: 0.7, FDR P-value:0.07
    174727_at Fold Change: 0.7, FDR P-value:0.05
    174731_s_at Fold Change: 0.7, FDR P-value:0.08
    174752_at Fold Change: 0.7, FDR P-value:0.08
    174755_s_at Fold Change: 0.7, FDR P-value:0.08
    174757_at Fold Change: 0.7, FDR P-value:0.07
    174787_at Fold Change: 0.7, FDR P-value:0.07
    174794_at Fold Change: 0.7, FDR P-value:0.08
    174836_at Fold Change: 0.7, FDR P-value:0.08
    174846_at Fold Change: 0.7, FDR P-value:0.08
    174859_at Fold Change: 0.7, FDR P-value:0.08
    174866_at Fold Change: 0.7, FDR P-value:0.08
    174877_at Fold Change: 0.7, FDR P-value:0.08
    174889_s_at Fold Change: 0.7, FDR P-value:0.07
    174898_at Fold Change: 0.7, FDR P-value:0.07
    174921_s_at Fold Change: 0.7, FDR P-value:0.08
    174932_at Fold Change: 0.7, FDR P-value:0.08
    174955_at Fold Change: 0.7, FDR P-value:0.08
    174979_at Fold Change: 0.7, FDR P-value:0.08
    174987_at Fold Change: 0.7, FDR P-value:0.07
    174990_at Fold Change: 0.7, FDR P-value:0.07
    174991_at Fold Change: 0.7, FDR P-value:0.08
    174999_at Fold Change: 0.7, FDR P-value:0.08
    175014_at Fold Change: 0.7, FDR P-value:0.08
    175044_at Fold Change: 0.7, FDR P-value:0.08
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    172630_x_at Fold Change: 0.5, FDR P-value:0.07
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  Attribute_of: Microarray_experiment (27)
  Regulation: Regulated_by_treatment: Treatment with 2.0mM of HuminFeed until young adult stage (3 days).
    Regulated_by_molecule: WBMol:00002927
  Associated_with: Life_stage: WBls:0000057