WormBase Tree Display for Gene: WBGene00011376
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| WBGene00011376 | SMap | S_parent | Sequence | T02E1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | gla-3 | Paper_evidence | WBPaper00028398 | |||||
| Person_evidence | WBPerson250 | ||||||||
| Sequence_name | T02E1.3 | ||||||||
| Molecular_name | T02E1.3a | ||||||||
| T02E1.3a.1 | |||||||||
| CE32481 | |||||||||
| T02E1.3b | |||||||||
| CE18171 | |||||||||
| T02E1.3c | |||||||||
| CE18170 | |||||||||
| T02E1.3b.1 | |||||||||
| T02E1.3c.1 | |||||||||
| Other_name | CELE_T02E1.3 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | gla-3 | ||||||||
| DB_info | Database | AceView | gene | 1I793 | |||||
| WormQTL | gene | WBGene00011376 | |||||||
| WormFlux | gene | WBGene00011376 | |||||||
| NDB | locus_tag | CELE_T02E1.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00011376|UniProtKB=O02289 | |||||||
| family | PTHR12547 | ||||||||
| NCBI | gene | 172604 | |||||||
| RefSeq | protein | NM_059838.4 | |||||||
| NM_059837.7 | |||||||||
| NM_001263777.3 | |||||||||
| TrEMBL | UniProtAcc | Q4JFB7 | |||||||
| O02289 | |||||||||
| B9WRT8 | |||||||||
| UniProt_GCRP | UniProtAcc | O02289 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 24 Aug 2006 10:36:57 | WBPerson2970 | Name_change | CGC_name | gla-3 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gla | ||||||||
| Allele (50) | |||||||||
| Strain | WBStrain00032710 | ||||||||
| WBStrain00040532 | |||||||||
| WBStrain00040533 | |||||||||
| WBStrain00040534 | |||||||||
| WBStrain00004784 | |||||||||
| WBStrain00005746 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00006590 | ||||||||
| 00026942 | |||||||||
| 00026943 | |||||||||
| 00026944 | |||||||||
| 00026945 | |||||||||
| 00026946 | |||||||||
| 00026947 | |||||||||
| 00118645 | |||||||||
| Ortholog (84) | |||||||||
| Paralog (20) | |||||||||
| Structured_description | Concise_description | gla-3 encodes a TIS11-like protein with two CCCH-like zinc-fingerdomains that inhibits apoptosis in the germline, and weakly inhibitsRAS signalling in vulval development along with RAS-induced muscleprotein degradation; GLA-3 inhibits physiological apoptosis inoocytes, keeping it down to a normal level of ~50% in hermaphroditegonads; gla-3 is expressed in the germline of L4 larvae and adults,and interacts with mpk-1 both genetically and physically; gla-3requires core apoptotic proteins (CED-3 and CED-4) for its excessapoptotic mutant phenotype, but not others (CEP-1, CLK-2, or HUS-1)required for DNA damage-induced apoptosis; gla-3 mutants haveincreased germline apoptosis and reduced brood size due to defectivepachytene exit from meiosis I, and also show weak enhancment of themultivulva phenotype of let-60(gf) or lip-1(zh15) mutations; gla-3mutants have temperature-sensitive progressive muscle dystrophy,consistent with hyperactivation of the RAS/MAPK pathway in musclecells; gla-3(RNAi) hermaphrodites display elevated levels ofphysiological germline apoptosis, independent of CEP-1. | Paper_evidence | WBPaper00023909 | |||||
| WBPaper00028398 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 18 Apr 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable metal ion binding activity. Located in cell cortex. Expressed in germ line; muscle cell; and somatic cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T02E1.3a | |||||||
| T02E1.3b | |||||||||
| T02E1.3c | |||||||||
| Corresponding_CDS_history | T02E1.3a:wp90 | ||||||||
| Corresponding_transcript | T02E1.3a.1 | ||||||||
| T02E1.3b.1 | |||||||||
| T02E1.3c.1 | |||||||||
| Other_sequence | CJC10573_1 | ||||||||
| Associated_feature | WBsf656614 | ||||||||
| WBsf978532 | |||||||||
| WBsf984370 | |||||||||
| WBsf984371 | |||||||||
| WBsf984372 | |||||||||
| WBsf1010199 | |||||||||
| WBsf1010200 | |||||||||
| WBsf218132 | |||||||||
| WBsf218133 | |||||||||
| Transcription_factor | WBTranscriptionFactor000845 | ||||||||
| Experimental_info | RNAi_result (23) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00001395 | ||||||||
| WBCnstr00030701 | |||||||||
| Construct_product | WBCnstr00030701 | ||||||||
| Antibody | WBAntibody00001133 | ||||||||
| WBAntibody00001134 | |||||||||
| Microarray_results (35) | |||||||||
| Expression_cluster (179) | |||||||||
| Interaction (229) | |||||||||
| Map_info | Map | I | Position | 2.67909 | Error | 0.008301 | |||
| Positive | Positive_clone | T02E1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
