WormBase Tree Display for Gene: WBGene00012641
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| WBGene00012641 | SMap | S_parent | Sequence | Y39A1A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | epg-6 | Paper_evidence | WBPaper00039980 | |||||
| Person_evidence | WBPerson716 | ||||||||
| Sequence_name | Y39A1A.1 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | CELE_Y39A1A.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | epg-6 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:54 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 12 Aug 2011 13:38:18 | WBPerson2970 | Name_change | CGC_name | epg-6 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | epg | ||||||||
| Allele (63) | |||||||||
| Strain | WBStrain00002335 | ||||||||
| WBStrain00008602 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Contained_in_operon | CEOP3684 | ||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00018294 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | epg-6 encodes a WD40 repeat-containing protein that is related to the mammalian WIPI3/4 family of proteins (WD40 repeat protein interacting with phosphoinositides); in C. elegans, epg-6 activity is required for autophagic processes, specifically for the formation of autophagosomes from omegasomes (PtdIns(3)P-enriched endoplasmic reticulum subdomains) and for proper distribution of the autophagic proteins ATG-9 and EPG-1; EPG-6 binds ATG-2 in vitro and in vivo and also binds, in vitro, PtdIns(3)P and PtdIns(5)P and weakly binds PtdIns(4)P and PtdIns(3,5)P2; an EGP-6::GFP reporter fusion protein is widely expressed during embryonic and post-embryonic development, and localizes diffusely to the cytoplasm. | Paper_evidence | WBPaper00039980 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 03 Aug 2011 00:00:00 | ||||||||
| Automated_description | Enables phosphatidylinositol phosphate binding activity. Involved in autophagosome assembly. Located in cytoplasm. Expressed widely. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation 5. Is an ortholog of human WDR45 (WD repeat domain 45). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110739 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:28912) | ||||
| Molecular_info | Corresponding_CDS | Y39A1A.1a | |||||||
| Y39A1A.1b | |||||||||
| Y39A1A.1c | |||||||||
| Y39A1A.1d | |||||||||
| Corresponding_CDS_history | Y39A1A.1:wp61 | ||||||||
| Y39A1A.1:wp93 | |||||||||
| Corresponding_transcript | Y39A1A.1a.1 | ||||||||
| Y39A1A.1b.1 | |||||||||
| Y39A1A.1c.1 | |||||||||
| Y39A1A.1d.1 | |||||||||
| Other_sequence (21) | |||||||||
| Associated_feature | WBsf651465 | ||||||||
| WBsf651466 | |||||||||
| WBsf994086 | |||||||||
| WBsf994087 | |||||||||
| WBsf227477 | |||||||||
| WBsf227478 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00056104 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00056114 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00036878 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022479 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092355 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066590 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00006740 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00006298 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092356 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1690 | ||||||||
| Expr6939 | |||||||||
| Expr9612 | |||||||||
| Expr1020256 | |||||||||
| Expr1035583 | |||||||||
| Expr1159613 | |||||||||
| Expr2011345 | |||||||||
| Expr2029581 | |||||||||
| Drives_construct | WBCnstr00003004 | ||||||||
| WBCnstr00014173 | |||||||||
| Construct_product | WBCnstr00014173 | ||||||||
| Microarray_results (29) | |||||||||
| Expression_cluster (109) | |||||||||
| Interaction (20) | |||||||||
| Map_info | Map | III | Position | 3.81526 | Error | 0.046215 | |||
| Positive | Positive_clone | Y39A1A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
