WormBase Tree Display for Gene: WBGene00004699

WBGene00004699 SMap: S_parent: Sequence: W02B12
  Identity: Version: 1
    Name: CGC_name: rsp-2 Person_evidence: WBPerson297
      Sequence_name: W02B12.2
      Molecular_name: W02B12.2
        W02B12.2.1
        CE03762
      Other_name: srp-4
        CeSRp40
        CELE_W02B12.2 Accession_evidence: NDB BX284602
      Public_name: rsp-2
    DB_info: Database: AceView gene 2L742
        WormQTL gene WBGene00004699
        WormFlux gene WBGene00004699
        NDB locus_tag CELE_W02B12.2
        Panther gene CAEEL|WormBase=WBGene00004699|UniProtKB=Q23120
          family PTHR23147
        NCBI gene 174747
        RefSeq protein NM_064040.7
        SwissProt UniProtAcc Q23120
        TREEFAM TREEFAM_ID TF351335
        UniProt_GCRP UniProtAcc Q23120
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rsp
    Allele (30)
    Strain: WBStrain00035790
    RNASeq_FPKM (74)
    GO_annotation (23)
    Ortholog (31)
    Paralog: WBGene00004698 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004700 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004702 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013307 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020399 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: rsp-2 encodes the C. elegans ortholog of the vertebrate SRp40 splicing factor and member of the SR protein family of nuclear phosphoproteins that are required for constitutive splicing and influence alternative splicing regulation. Paper_evidence: WBPaper00003988
          Curator_confirmed: WBPerson1843
          Date_last_updated: 20 Mar 2012 00:00:00
      Automated_description: Predicted to enable RNA binding activity. Involved in developmental process involved in reproduction; nematode larval development; and regulation of growth rate. Located in nucleus. Expressed widely. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; carcinoma (multiple); and proliferative diabetic retinopathy. Is an ortholog of human SRSF5 (serine and arginine rich splicing factor 5) and SRSF6 (serine and arginine rich splicing factor 6). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:4467 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10787,HGNC:10788)
      DOID:234 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10787,HGNC:10788)
      DOID:0070168 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10788)
      DOID:4159 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10788)
      DOID:1324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10788)
      DOID:12858 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10788)
      DOID:13207 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10788)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10787)
  Molecular_info: Corresponding_CDS: W02B12.2
    Corresponding_transcript: W02B12.2.1
    Other_sequence (61)
    Associated_feature: WBsf650575
      WBsf650576
      WBsf650577
      WBsf655392
      WBsf665274
      WBsf666138
      WBsf989763
      WBsf1013240
      WBsf223935
      WBsf223936
  Experimental_info: RNAi_result (35)
    Expr_pattern: Expr1142
      Expr1013873
      Expr1032319
      Expr1158104
      Expr2015559
      Expr2033794
    Drives_construct: WBCnstr00010104
    Microarray_results (20)
    Expression_cluster (138)
    Interaction (28)
  Map_info: Map: II Position: 3.46842 Error: 0.000911
    Positive: Positive_clone: W02B12 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4647
    Pseudo_map_position
  Reference (11)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene