rsp-2 encodes the C. elegans ortholog of the vertebrate SRp40 splicing factor and member of the SR protein family of nuclear phosphoproteins that are required for constitutive splicing and influence alternative splicing regulation.
Predicted to enable RNA binding activity. Involved in developmental process involved in reproduction; nematode larval development; and regulation of growth rate. Located in nucleus. Expressed widely. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; carcinoma (multiple); and proliferative diabetic retinopathy. Is an ortholog of human SRSF5 (serine and arginine rich splicing factor 5) and SRSF6 (serine and arginine rich splicing factor 6).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.