WormBase Tree Display for Gene: WBGene00002012
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| WBGene00002012 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F38E11 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | hsp-12.3 | Person_evidence | WBPerson36 | |||||
| Sequence_name | F38E11.1 | ||||||||
| Molecular_name | F38E11.1 | ||||||||
| F38E11.1.1 | |||||||||
| CE03293 | |||||||||
| Other_name | CELE_F38E11.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | hsp-12.3 | ||||||||
| DB_info | Database | AceView | gene | 4K208 | |||||
| WormQTL | gene | WBGene00002012 | |||||||
| WormFlux | gene | WBGene00002012 | |||||||
| NDB | locus_tag | CELE_F38E11.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002012|UniProtKB=Q20164 | |||||||
| family | PTHR45640 | ||||||||
| NCBI | gene | 177777 | |||||||
| RefSeq | protein | NM_069266.2 | |||||||
| TrEMBL | UniProtAcc | Q20164 | |||||||
| UniProt_GCRP | UniProtAcc | Q20164 | |||||||
| OMIM | gene | 123580 | |||||||
| 123590 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hsp | ||||||||
| Allele (13) | |||||||||
| Legacy_information | small heat shock proteins | ||||||||
| Strain | WBStrain00037273 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00067372 | ||||||||
| 00067373 | |||||||||
| 00067374 | |||||||||
| 00067375 | |||||||||
| 00067376 | |||||||||
| 00067377 | |||||||||
| Ortholog (49) | |||||||||
| Paralog (17) | |||||||||
| Structured_description | Concise_description | hsp-12.3 encodes a small heat-shock protein that forms heterotetramerswith HSP-12.2 and has no chaperone-like activity; structurally, HSP-12.3is mostly a beta-sheet; at least one HSP-12 (which may or may not beHSP-12.2) is ubiquitously expressed in L1 larvae, and later expressed inadult spermatids (and perhaps spermatocytes), and some adult vulvalcells; hsp-12.3 is upregulated in daf-2 mutants, suggesting thathsp-12.3's expression may contribute to prolonged lifespan in dauerlarvae. | Paper_evidence | WBPaper00003194 | |||||
| WBPaper00004387 | |||||||||
| WBPaper00005896 | |||||||||
| WBPaper00025088 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 31 Jan 2007 00:00:00 | ||||||||
| Automated_description | Enables heat shock protein binding activity. Predicted to be involved in protein refolding and response to heat. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in cataract (multiple); dilated cardiomyopathy 1II; and myofibrillar myopathy (multiple). Is an ortholog of human CRYAA (crystallin alpha A); CRYAB (crystallin alpha B); and HSPB6 (heat shock protein family B (small) member 6). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2389) | ||||
| DOID:0080093 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2389) | ||||||
| DOID:0110266 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2388) | ||||||
| DOID:0110250 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2389) | ||||||
| DOID:0080309 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2389) | ||||||
| Molecular_info | Corresponding_CDS | F38E11.1 | |||||||
| Corresponding_transcript | F38E11.1.1 | ||||||||
| Other_sequence (21) | |||||||||
| Associated_feature | WBsf652061 | ||||||||
| WBsf652062 | |||||||||
| WBsf230571 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00031965 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00046715 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062703 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076394 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106378 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00014567 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092853 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr15514 | ||||||||
| Expr1024927 | |||||||||
| Expr1031175 | |||||||||
| Expr1150595 | |||||||||
| Expr2012614 | |||||||||
| Expr2030850 | |||||||||
| Drives_construct | WBCnstr00036523 | ||||||||
| WBCnstr00042205 | |||||||||
| Construct_product | WBCnstr00036523 | ||||||||
| WBCnstr00042205 | |||||||||
| Antibody | WBAntibody00003012 | ||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (289) | |||||||||
| Interaction (54) | |||||||||
| Map_info | Map | IV | Position | 4.25208 | Error | 0.002586 | |||
| Positive | Positive_clone | F38E11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (15) | |||||||||
| Remark | email54 from wen chen. | ||||||||
| Sequence connection from [Kokke BPA, Candido EPM] | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
