WormBase Tree Display for Gene: WBGene00006944
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| WBGene00006944 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F18C5 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | wrn-1 | Person_evidence | WBPerson1551 | |||||
| Sequence_name | F18C5.2 | ||||||||
| Molecular_name | F18C5.2 | ||||||||
| F18C5.2.1 | |||||||||
| CE31791 | |||||||||
| Other_name | CELE_F18C5.2 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | wrn-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | wrn | ||||||||
| Allele (50) | |||||||||
| Strain | WBStrain00035559 | ||||||||
| WBStrain00035569 | |||||||||
| WBStrain00028633 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (43) | |||||||||
| Contained_in_operon | CEOP2250 | ||||||||
| Ortholog (30) | |||||||||
| Paralog | WBGene00001865 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00004322 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00019334 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | wrn-1 encodes an ortholog of human WRN, and one of four C. elegans homologs of the RecQ DNA helicase family, that includes E. coli RecQ; by homology, WRN-1 is predicted to function as a helicase, DNA-dependent ATPase, and exonuclease that plays a key role in DNA replication, recombination, and repair; RNA interference studies in C. elegans and the enhancement of many of the resulting phenotypes by ionizing radiation indicate that wrn-1 affects life span and aging and acts at a DNA damage checkpoint; the wrn-1 phenotypes such as premature aging are similar to those of Werner syndrome; immunolocalization studies indicate that WRN-1 expression is nuclear in cells at the embryonic, larval and adult stages. | Paper_evidence | WBPaper00004103 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00024206 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 13 Jul 2007 00:00:00 | ||||||||
| Automated_description | Enables 3'-5' DNA helicase activity. Involved in DNA metabolic process; determination of adult lifespan; and response to ionizing radiation. Located in nucleoplasm and site of double-strand break. Expressed in several structures, including AWCL; AWCR; and germ line. Used to study Werner syndrome. Human ortholog(s) of this gene implicated in several diseases, including Werner syndrome; diffuse scleroderma; and senile cataract. Is an ortholog of human WRN (WRN RecQ like helicase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:5688 | Homo sapiens | Paper_evidence | WBPaper00024206 | ||||
| WBPaper00035587 | |||||||||
| Accession_evidence | OMIM | 277700 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Mar 2018 00:00:00 | ||||||||
| Potential_model | DOID:397 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12791) | |||||
| DOID:9669 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12791) | ||||||
| DOID:5844 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12791) | ||||||
| DOID:5688 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12791) | ||||||
| DOID:3393 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12791) | ||||||
| DOID:1580 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12791) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12791) | ||||||
| Disease_relevance | In humans, mutations in RecQ Protein-like 2 (RECQL2, also called RECQ3 or WRN) are implicated in Werner Syndrome, a human autosomal recessive aging disorder, characterized by genomic instability and the premature onset of several age-related diseases; WRN contains both a exonuclease and helicase activity and is involved in DNA repair, replication, transcription and telomere maintenance; in elegans, which is used as a model system to study wrn-1 function, knockdown of wrn-1/WRN shortens lifespan, increases sensitivity to DNA damage and accelerates aging phenotypes; further studies in elegans and mice indicate that in wrn-1 mutant animals the microRNA miR-124 is significantly reduced; mir-124 mutants in elegans show reduced lifespan, increased reactive oxygen species (ROS) and reduction in ATP levels; double mutants of mir-124 and wrn-1 showed further reduction in lifespan and ATP levels, and increased ROS generation. | Homo sapiens | Paper_evidence | WBPaper00041652 | |||||
| Accession_evidence | OMIM | 277700 | |||||||
| 604611 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 18 Dec 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000104 | ||||||||
| Models_disease_asserted | WBDOannot00000490 | ||||||||
| WBDOannot00000623 | |||||||||
| Molecular_info | Corresponding_CDS | F18C5.2 | |||||||
| Corresponding_CDS_history | F18C5.2:wp84 | ||||||||
| Corresponding_transcript | F18C5.2.1 | ||||||||
| Other_sequence | CBC01319_1 | ||||||||
| CBC04646_1 | |||||||||
| CGC01379_1 | |||||||||
| MI07460 | |||||||||
| HGC08269_1 | |||||||||
| HG01847 | |||||||||
| JI166562.1 | |||||||||
| MIC06628_1 | |||||||||
| Acan_isotig22647 | |||||||||
| Associated_feature | WBsf221461 | ||||||||
| WBsf221462 | |||||||||
| WBsf221463 | |||||||||
| WBsf221464 | |||||||||
| WBsf221465 | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern | Expr2942 | ||||||||
| Expr15680 | |||||||||
| Expr15681 | |||||||||
| Expr16188 | |||||||||
| Expr1023514 | |||||||||
| Expr1032958 | |||||||||
| Expr1148902 | |||||||||
| Expr2018074 | |||||||||
| Expr2036212 | |||||||||
| Drives_construct | WBCnstr00034082 | ||||||||
| WBCnstr00042477 | |||||||||
| Construct_product | WBCnstr00034082 | ||||||||
| WBCnstr00042478 | |||||||||
| Regulate_expr_cluster | WBPaper00045934:wrn-1(gk99)_downregulated | ||||||||
| WBPaper00045934:wrn-1(gk99)_upregulated | |||||||||
| Antibody | WBAntibody00000892 | ||||||||
| WBAntibody00002088 | |||||||||
| WBAntibody00002089 | |||||||||
| WBAntibody00002308 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (83) | |||||||||
| SAGE_tag | SAGE:tcacctgaaa | Strand | Sense | ||||||
| Unambiguously_mapped | |||||||||
| SAGE:ggttgaagctatgggag | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:tttgcaattc | Strand | Antisense | |||||||
| SAGE:aagtagcacc | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:ggatgatgga | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:aatcatcacatttgttc | Strand | Antisense | |||||||
| SAGE:ggttgaagct | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| Interaction (86) | |||||||||
| Map_info | Map | II | Position | -0.126695 | Error | 0.005227 | |||
| Positive | Positive_clone | F18C5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4648 | |||||||
| 4756 | |||||||||
| 5596 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (36) | |||||||||
| Remark | Sequence connection from [Boulton S, Vidal M] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
