| WBGene00006944 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | F18C5 |
| Identity | Version | 1 |
| | Name | CGC_name | wrn-1 | Person_evidence | WBPerson1551 |
| | | Sequence_name | F18C5.2 |
| | | Molecular_name | F18C5.2 |
| | | | F18C5.2.1 |
| | | | CE31791 |
| | | Other_name | CELE_F18C5.2 | Accession_evidence | NDB | BX284602 |
| | | Public_name | wrn-1 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | wrn |
| | Allele (50) |
| | Strain | WBStrain00035559 |
| | | WBStrain00035569 |
| | | WBStrain00028633 |
| | RNASeq_FPKM (74) |
| | GO_annotation (43) |
| | Contained_in_operon | CEOP2250 |
| | Ortholog (30) |
| | Paralog | WBGene00001865 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004322 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00019334 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | wrn-1 encodes an ortholog of human WRN, and one of four C. elegans homologs of the RecQ DNA helicase family, that includes E. coli RecQ; by homology, WRN-1 is predicted to function as a helicase, DNA-dependent ATPase, and exonuclease that plays a key role in DNA replication, recombination, and repair; RNA interference studies in C. elegans and the enhancement of many of the resulting phenotypes by ionizing radiation indicate that wrn-1 affects life span and aging and acts at a DNA damage checkpoint; the wrn-1 phenotypes such as premature aging are similar to those of Werner syndrome; immunolocalization studies indicate that WRN-1 expression is nuclear in cells at the embryonic, larval and adult stages. | Paper_evidence | WBPaper00004103 |
| | | | | | WBPaper00005654 |
| | | | | | WBPaper00024206 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson324 |
| | | | | Date_last_updated | 13 Jul 2007 00:00:00 |
| | | Automated_description | Enables 3'-5' DNA helicase activity. Involved in DNA metabolic process; determination of adult lifespan; and response to ionizing radiation. Located in nucleoplasm and site of double-strand break. Expressed in several structures, including AWCL; AWCR; and germ line. Used to study Werner syndrome. Human ortholog(s) of this gene implicated in several diseases, including Werner syndrome; diffuse scleroderma; and senile cataract. Is an ortholog of human WRN (WRN RecQ like helicase). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:5688 | Homo sapiens | Paper_evidence | WBPaper00024206 |
| | | | | | WBPaper00035587 |
| | | | | Accession_evidence | OMIM | 277700 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 06 Mar 2018 00:00:00 |
| | Potential_model | DOID:397 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12791) |
| | | DOID:9669 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12791) |
| | | DOID:5844 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12791) |
| | | DOID:5688 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12791) |
| | | DOID:3393 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12791) |
| | | DOID:1580 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12791) |
| | | DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12791) |
| | Disease_relevance | In humans, mutations in RecQ Protein-like 2 (RECQL2, also called RECQ3 or WRN) are implicated in Werner Syndrome, a human autosomal recessive aging disorder, characterized by genomic instability and the premature onset of several age-related diseases; WRN contains both a exonuclease and helicase activity and is involved in DNA repair, replication, transcription and telomere maintenance; in elegans, which is used as a model system to study wrn-1 function, knockdown of wrn-1/WRN shortens lifespan, increases sensitivity to DNA damage and accelerates aging phenotypes; further studies in elegans and mice indicate that in wrn-1 mutant animals the microRNA miR-124 is significantly reduced; mir-124 mutants in elegans show reduced lifespan, increased reactive oxygen species (ROS) and reduction in ATP levels; double mutants of mir-124 and wrn-1 showed further reduction in lifespan and ATP levels, and increased ROS generation. | Homo sapiens | Paper_evidence | WBPaper00041652 |
| | | | | Accession_evidence | OMIM | 277700 |
| | | | | | | 604611 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 18 Dec 2013 00:00:00 |
| Models_disease_in_annotation | WBDOannot00000104 |
| Models_disease_asserted | WBDOannot00000490 |
| | WBDOannot00000623 |
| Molecular_info | Corresponding_CDS | F18C5.2 |
| | Corresponding_CDS_history | F18C5.2:wp84 |
| | Corresponding_transcript | F18C5.2.1 |
| | Other_sequence | CBC01319_1 |
| | | CBC04646_1 |
| | | CGC01379_1 |
| | | MI07460 |
| | | HGC08269_1 |
| | | HG01847 |
| | | JI166562.1 |
| | | MIC06628_1 |
| | | Acan_isotig22647 |
| | Associated_feature | WBsf221461 |
| | | WBsf221462 |
| | | WBsf221463 |
| | | WBsf221464 |
| | | WBsf221465 |
| Experimental_info | RNAi_result (16) |
| | Expr_pattern | Expr2942 |
| | | Expr15680 |
| | | Expr15681 |
| | | Expr16188 |
| | | Expr1023514 |
| | | Expr1032958 |
| | | Expr1148902 |
| | | Expr2018074 |
| | | Expr2036212 |
| | Drives_construct | WBCnstr00034082 |
| | | WBCnstr00042477 |
| | Construct_product | WBCnstr00034082 |
| | | WBCnstr00042478 |
| | Regulate_expr_cluster | WBPaper00045934:wrn-1(gk99)_downregulated |
| | | WBPaper00045934:wrn-1(gk99)_upregulated |
| | Antibody | WBAntibody00000892 |
| | | WBAntibody00002088 |
| | | WBAntibody00002089 |
| | | WBAntibody00002308 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033070:Elbe_upregulated |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045417:128Q-huntingtin_upreglated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_downregulated_N2 |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00049954:BPS_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:stavudine_72h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061340:URA_parent |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection |
| | | WBPaper00061527:T02E1.2-uri-1 |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00036286:Pattern_B |
| | | WBPaper00038060:SUMO-1_upregulated |
| | | WBPaper00040823:alg-1(gk214)_downregulated |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00048637:lin-35(n745)_starvation_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:oogenesis-enriched |
| | SAGE_tag | SAGE:tcacctgaaa | Strand | Sense |
| | | | Unambiguously_mapped |
| | | SAGE:ggttgaagctatgggag | Strand | Sense |
| | | | Unambiguously_mapped |
| | | SAGE:tttgcaattc | Strand | Antisense |
| | | SAGE:aagtagcacc | Strand | Sense |
| | | | Unambiguously_mapped |
| | | SAGE:ggatgatgga | Strand | Sense |
| | | | Unambiguously_mapped |
| | | SAGE:aatcatcacatttgttc | Strand | Antisense |
| | | SAGE:ggttgaagct | Strand | Sense |
| | | | Unambiguously_mapped |
| | Interaction (86) |
| Map_info | Map | II | Position | -0.126695 | Error | 0.005227 |
| | Positive | Positive_clone | F18C5 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4648 |
| | | | 4756 |
| | | | 5596 |
| | Pseudo_map_position |
| Reference (36) |
| Remark | Sequence connection from [Boulton S, Vidal M] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
