WormBase Tree Display for Gene: WBGene00001865
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| WBGene00001865 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T04A11 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | him-6 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T04A11.6 | ||||||||
| Molecular_name | T04A11.6 | ||||||||
| T04A11.6.1 | |||||||||
| CE31724 | |||||||||
| Other_name | blm-1 | ||||||||
| CELE_T04A11.6 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | him-6 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info (11) | |||||||||
| Disease_info | Experimental_model | DOID:2717 | Homo sapiens | Paper_evidence | WBPaper00013454 | ||||
| Accession_evidence | OMIM | 210900 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 05 Jun 2017 00:00:00 | ||||||||
| Potential_model | DOID:2717 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1058) | |||||
| Disease_relevance | Mutations in the human BLM gene (a RecQ family DNA helicase) are implicatd in Bloom syndrome, an inherited disorder characterized by short stature, increased sensitivity to sunlight, a greatly increased risk of cancer and infertility; at the cellular level it is characterized by genomic instability, in particular, hyperrecombination between sister chromatids and homologous chromosomes; the C. elegans BLM ortholog, him-6, exhibits DNA-dependent ATPase activity and mutants show an enhanced irradiation sensitivity, a partially defective S-phase checkpoint, and in reduced levels of DNA-damage induced apoptosis. | Homo sapiens | Paper_evidence | WBPaper00013454 | |||||
| Accession_evidence | OMIM | 604610 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 05 Jun 2017 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000132 | ||||||||
| WBDOannot00000436 | |||||||||
| WBDOannot00000437 | |||||||||
| WBDOannot00000438 | |||||||||
| Molecular_info | Corresponding_CDS | T04A11.6 | |||||||
| Corresponding_CDS_history | T04A11.6:wp84 | ||||||||
| Corresponding_transcript | T04A11.6.1 | ||||||||
| Other_sequence (32) | |||||||||
| Associated_feature | WBsf660814 | ||||||||
| WBsf660815 | |||||||||
| WBsf998136 | |||||||||
| WBsf998137 | |||||||||
| WBsf1018380 | |||||||||
| WBsf1018381 | |||||||||
| WBsf229300 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00008018 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00075599 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00052319 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00018100 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1024637 | ||||||||
| Expr1031098 | |||||||||
| Expr1155954 | |||||||||
| Expr2012431 | |||||||||
| Expr2030667 | |||||||||
| Drives_construct | WBCnstr00036640 | ||||||||
| Construct_product | WBCnstr00036640 | ||||||||
| Antibody | WBAntibody00002533 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (125) | |||||||||
| Interaction (123) | |||||||||
| Map_info | Map | IV | Position | 5.98937 | Error | 0.002716 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | T04A11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 111 | |||||||
| 112 | |||||||||
| 113 | |||||||||
| 5281 | |||||||||
| 5470 | |||||||||
| Pos_neg_data | 5444 | ||||||||
| 5445 | |||||||||
| 5446 | |||||||||
| 5447 | |||||||||
| Reference (74) | |||||||||
| Remark | Sequence connection from [Wicky C, Muller F] | ||||||||
| Method | Gene |
