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WormBase Tree Display for Gene: WBGene00003096

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Name Class

WBGene00003096SMapS_parentSequenceC02A12
IdentityVersion1
NameCGC_namelys-7Person_evidenceWBPerson168
Sequence_nameC02A12.4
Molecular_nameC02A12.4
C02A12.4.1
CE07828
Other_nameCELE_C02A12.4Accession_evidenceNDBBX284605
Public_namelys-7
DB_infoDatabaseAceViewgene5D960
WormQTLgeneWBGene00003096
WormFluxgeneWBGene00003096
NDBlocus_tagCELE_C02A12.4
PanthergeneCAEEL|WormBase=WBGene00003096|UniProtKB=O16202
familyPTHR23208
NCBIgene178772
RefSeqproteinNM_071571.9
SwissProtUniProtAccO16202
TREEFAMTREEFAM_IDTF316378
UniProt_GCRPUniProtAccO16202
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:30WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlys
Allele (30)
StrainWBStrain00031984
WBStrain00031985
WBStrain00004711
WBStrain00004740
RNASeq_FPKM (74)
GO_annotation (13)
Ortholog (37)
ParalogWBGene00003090Caenorhabditis elegansFrom_analysisInparanoid_8
Panther
WormBase-Compara
WBGene00003091Caenorhabditis elegansFrom_analysisInparanoid_8
Panther
WormBase-Compara
WBGene00003092Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003093Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003094Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003095Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003097Caenorhabditis elegansFrom_analysisInparanoid_8
Panther
WormBase-Compara
WBGene00003098Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003099Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionlys-7 encodes an enzyme homologous to an antimicrobial lysozyme encoded by the LYS4 gene of the protozoan parasite Entamoeba histolytica; LYS-7 functions in the innate immune response as an antimicrobial enzyme that, by homology, hydrolyzes the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of prokaryotic cell walls; loss of lys-7 activity results in enhanced susceptibility to P. aeruginosa PA14, renders worms susceptible to Cryptococcus neoformans killing, but enhances tolerance to the enteric bacteria Salmonella typhimurium; lys-7 expression is significantly upregulated in response to infection with the Gram-negative bacterium Serratia marcescens; constitutive expression of lys-7 mRNA is detected in the intestine and the intestinal valve cells.Paper_evidenceWBPaper00004651
WBPaper00005382
WBPaper00005569
WBPaper00005654
WBPaper00041211
WBPaper00038223
WBPaper00032276
Curator_confirmedWBPerson1843
Date_last_updated19 Feb 2014 00:00:00
Automated_descriptionInvolved in defense response to other organism. Expressed in head neurons; intestine; and rectal gland cell.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS290 version of WormBase
Date_last_updated11 Sep 2023 00:00:00
Molecular_infoCorresponding_CDSC02A12.4
Corresponding_transcriptC02A12.4.1
Other_sequence (84)
Associated_featureWBsf019148
WBsf019149
WBsf652532
WBsf233493
WBsf233494
Experimental_infoRNAi_result (21)
Expr_patternExpr1973
Expr4716
Expr10716
Expr1018008
Expr1143497
Expr2013318
Expr2031549
Drives_constructWBCnstr00009965
WBCnstr00012193
WBCnstr00015892
WBCnstr00017492
WBCnstr00036232
WBCnstr00041439
Construct_productWBCnstr00009965
WBCnstr00012193
WBCnstr00036232
Microarray_results (18)
Expression_cluster (404)
Interaction (200)
WBProcessWBbiopr:00000008
WBbiopr:00000039
Map_infoMapVPosition-10.8998Error0.024633
PositivePositive_cloneC02A12Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4881
4924
5423
Pos_neg_data10776
Pseudo_map_position
Reference (63)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene