WormBase Tree Display for Gene: WBGene00001161
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| WBGene00001161 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y102A5C | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | efl-1 | Person_evidence | WBPerson268 | |||||
| Sequence_name | Y102A5C.18 | ||||||||
| Molecular_name | Y102A5C.18 | ||||||||
| Y102A5C.18.1 | |||||||||
| CE20390 | |||||||||
| Other_name | mex-2 | ||||||||
| CELE_Y102A5C.18 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | efl-1 | ||||||||
| DB_info | Database | AceView | gene | 5R440 | |||||
| WormQTL | gene | WBGene00001161 | |||||||
| WormFlux | gene | WBGene00001161 | |||||||
| NDB | locus_tag | CELE_Y102A5C.18 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001161|UniProtKB=G5EF11 | |||||||
| family | PTHR12081 | ||||||||
| NCBI | gene | 180133 | |||||||
| RefSeq | protein | NM_074888.7 | |||||||
| TrEMBL | UniProtAcc | G5EF11 | |||||||
| UniProt_GCRP | UniProtAcc | G5EF11 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | efl | ||||||||
| Allele (291) | |||||||||
| Legacy_information | [C.elegansII] Mutation maternal effect lethal, leading to production of excess muscle cells, like Mex-1. [JJ] | ||||||||
| Strain | WBStrain00027369 | ||||||||
| WBStrain00036784 | |||||||||
| WBStrain00022494 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00001162 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00009899 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | efl-1 encodes a homolog of mammalian E2F that is required for embryonic asymmetry and that functions as a transcriptional repressor; during vulval development, efl-1, a class B synMuv gene, acts with class B synMuv genes dpl-1 and lin-35/Rb to antagonize receptor tyrosine kinase and Ras-mediated signaling; EFL-1 also negatively regulates the G1 to S phase cell cycle transition. | Paper_evidence | WBPaper00004589 | |||||
| WBPaper00004634 | |||||||||
| WBPaper00004635 | |||||||||
| WBPaper00005298 | |||||||||
| WBPaper00005708 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 10 Nov 2005 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including embryonic digestive tract morphogenesis; negative regulation of Ras protein signal transduction; and negative regulation of vulval development. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Expressed in gonad. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate carcinoma. Is an ortholog of human E2F4 (E2F transcription factor 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10286 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3119) | ||||
| DOID:3883 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3118) | ||||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3119) | ||||||
| Molecular_info | Corresponding_CDS | Y102A5C.18 | |||||||
| Corresponding_transcript | Y102A5C.18.1 | ||||||||
| Other_sequence (41) | |||||||||
| Associated_feature | WBsf653499 | ||||||||
| WBsf669813 | |||||||||
| WBsf978922 | |||||||||
| WBsf982066 | |||||||||
| WBsf1002576 | |||||||||
| WBsf1002577 | |||||||||
| WBsf1021218 | |||||||||
| WBsf1021219 | |||||||||
| Gene_product_binds (13485) | |||||||||
| Transcription_factor | WBTranscriptionFactor000455 | ||||||||
| Experimental_info | RNAi_result (52) | ||||||||
| Expr_pattern | Expr4031 | ||||||||
| Expr1016766 | |||||||||
| Expr1030739 | |||||||||
| Expr1158669 | |||||||||
| Expr2011189 | |||||||||
| Expr2029425 | |||||||||
| Drives_construct | WBCnstr00017291 | ||||||||
| Construct_product | WBCnstr00017289 | ||||||||
| WBCnstr00017291 | |||||||||
| WBCnstr00017292 | |||||||||
| Regulate_expr_cluster | WBPaper00027758:Group_I | ||||||||
| WBPaper00027758:Group_II | |||||||||
| WBPaper00027758:Group_III | |||||||||
| WBPaper00027758:Regulated_genes_not_in_group | |||||||||
| WBPaper00062056:efl-1(se1)_downregulated | |||||||||
| WBPaper00062056:efl-1(se1)_upregulated | |||||||||
| Antibody | WBAntibody00000356 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (141) | |||||||||
| Interaction (171) | |||||||||
| Product_binds_matrix (12) | |||||||||
| Map_info | Map | V | Position | 11.3775 | Error | 0.003321 | |||
| Positive | Positive_clone | Y54E10BL | |||||||
| Y102A5C | Inferred_automatically | From CDS info | |||||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4125 | |||||||
| 5410 | |||||||||
| Reference (76) | |||||||||
| Picture | WBPicture0000013091 | ||||||||
| Remark | [Ceol C, Horvitz HR] efl-1 Y102A5C.18 | ||||||||
| WE had this mis-linked to Y54E10BL.6 instead of the real gene mek-2. [sdm 010320] | |||||||||
| Sequence connection from [?] | |||||||||
| Y54E10BL.6 removed again. 09/2001 sdm | |||||||||
| Method | Gene |
