WormBase Tree Display for Gene: WBGene00006463
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WBGene00006463 | SMap | S_parent | Sequence | T26A5 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||||
Name | CGC_name | nduf-2.2 | |||||||
Sequence_name | T26A5.3 | ||||||||
Molecular_name | T26A5.3 | ||||||||
T26A5.3.1 | |||||||||
CE00702 | |||||||||
Other_name | tag-99 | ||||||||
ndus-2.2 | Person_evidence | WBPerson555 | |||||||
CELE_T26A5.3 | Accession_evidence | NDB | BX284603 | ||||||
Public_name | nduf-2.2 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 26 Feb 2008 13:57:13 | WBPerson2970 | Name_change | CGC_name | nduf-2.2 | ||||
Other_name | tag-99 | ||||||||
3 | 16 Jan 2023 18:37:21 | WBPerson51134 | Name_change | Other_name | ndus-2.2 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | nduf | ||||||||
Allele (32) | |||||||||
Strain | WBStrain00002835 | ||||||||
WBStrain00035734 | |||||||||
WBStrain00036874 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation | 00076471 | ||||||||
00076472 | |||||||||
00076473 | |||||||||
00076474 | |||||||||
00114112 | |||||||||
00114113 | |||||||||
00114114 | |||||||||
Contained_in_operon | CEOP3390 | ||||||||
Ortholog (43) | |||||||||
Paralog | WBGene00001520 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Inparanoid_8 | |||||||||
Panther | |||||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | T26A5.3 encodes a predicted mitochondrial protein whose mature sequencehas near-identity (95%) to GAS-1; T26A5.3 transcription is detectable byRT-PCR, but not visible by promoter-GFP fusion; however, a transgenecontaining a fusion of the gas-1 promoter to the T26A5.3 protein-codingsequence is able to fully rescue gas-1 mutants, indicating that T26A5.3encodes a fully functional mitochondrial 49 kDa subunit that may rescuegas-1(fc21) mutants from lethality; mutants homozygous for a T26A5.3deletion have normal anesthetic sensitivity and normal sensitivity tooxygen (unlike gas-1 mutants) but a shortened lifespan at normallaboratory oxygen levels (20%); animals doubly mutant for gas-1 andT26A5.3 have maternal-effect lethality, but sterile surviving parents areabnormally long-lived (2.7 times longer than wild-type and 4.2 timeslonger than gas-1 mutants); double mutants remain hypersensitive tooxygen. | Paper_evidence | WBPaper00024204 | |||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 12 Oct 2006 00:00:00 | ||||||||
Automated_description | Predicted to enable NAD binding activity; oxidoreductase activity, acting on NAD(P)H; and quinone binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in several diseases, including Leigh disease; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Is an ortholog of human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:11984 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7708) | ||||
DOID:3652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7708) | ||||||
DOID:2377 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7708) | ||||||
DOID:655 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7708) | ||||||
DOID:0112066 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7708) | ||||||
Molecular_info | Corresponding_CDS | T26A5.3 | |||||||
Corresponding_transcript | T26A5.3.1 | ||||||||
Other_sequence (92) | |||||||||
Associated_feature | WBsf645269 | ||||||||
WBsf981496 | |||||||||
WBsf225111 | |||||||||
Experimental_info | RNAi_result (11) | ||||||||
Expr_pattern | Chronogram940 | ||||||||
Expr1020340 | |||||||||
Expr1032634 | |||||||||
Expr1157711 | |||||||||
Expr2013932 | |||||||||
Expr2032171 | |||||||||
Drives_construct | WBCnstr00003357 | ||||||||
WBCnstr00037901 | |||||||||
Construct_product | WBCnstr00037901 | ||||||||
Microarray_results (18) | |||||||||
Expression_cluster (126) | |||||||||
Interaction (101) | |||||||||
Map_info | Map | III | Position | -1.24974 | Error | 0.010506 | |||
Positive | Positive_clone | T26A5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4136 | |||||||
4657 | |||||||||
5565 | |||||||||
Pseudo_map_position | |||||||||
Reference | WBPaper00004719 | ||||||||
WBPaper00005928 | |||||||||
WBPaper00015786 | |||||||||
WBPaper00023496 | |||||||||
WBPaper00024204 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00048006 | |||||||||
WBPaper00051291 | |||||||||
WBPaper00055090 | |||||||||
Remark | Gene name created from parsing 'genotype' field from CGC strain information | CGC_data_submission | |||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |