WormBase Tree Display for Gene: WBGene00001520
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| WBGene00001520 | SMap | S_parent | Sequence | K09A9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | gas-1 | Person_evidence | WBPerson431 | |||||
| Sequence_name | K09A9.5 | ||||||||
| Molecular_name | K09A9.5 | ||||||||
| K09A9.5.1 | |||||||||
| CE11980 | |||||||||
| Other_name | nduf-2.1 | ||||||||
| ndus-2.1 | Person_evidence | WBPerson555 | |||||||
| CELE_K09A9.5 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | gas-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 26 Feb 2008 13:49:33 | WBPerson2970 | Name_change | Other_name | nduf-2.1 | ||||
| 3 | 16 Jan 2023 18:37:21 | WBPerson51134 | Name_change | Other_name | ndus-2.1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gas | ||||||||
| Allele (69) | |||||||||
| Legacy_information | [Morgan PG] fc21 exhibits increased sensitivity to a variety of volatile anesthetics. Also ts lethal, with brood size of 10 - 20 at 25C, 50 - 100 at 20C. fc21/Df almost lethal, brood size 5 - 10. Probable hypomorph. Encodes NADH-ubiquinone reductase. Predicted gene K09A9.5 | ||||||||
| Strain | WBStrain00037441 | ||||||||
| WBStrain00005211 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00006463 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | The gas-1 gene encodes a 49 kDa subunit of mitochondrial complex I that is required for oxidative phosphorylation, resistance to volatile anesthetics, fecundity, and normal lifespan; gas-1 is expressed in the nematode neuromuscular system; its subcellular distribution appears to be mitochondrial; drug effects on mutants versus wild-type indicate that gas-1 functions at least partially through presynaptic effects; gas-1 mutants have strongly reduced Complex I-dependent metabolism in mitochondria, while Complex II-dependent metabolism is conversely increased in mutants; gas-1 mitochondria look structurally normal. | Paper_evidence | WBPaper00004719 | |||||
| WBPaper00028429 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 13 Dec 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable several functions, including 4 iron, 4 sulfur cluster binding activity; NAD binding activity; and NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and response to xenobiotic stimulus. Located in intracellular membrane-bounded organelle. Expressed in anterior gonad arm; body wall musculature; nervous system; non-striated muscle; and tail. Used to study alcohol use disorder and mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in several diseases, including Leigh disease; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Is an ortholog of human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00005840 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 29 Apr 2019 00:00:00 | ||||||||
| DOID:0060536 | Homo sapiens | Paper_evidence | WBPaper00046523 | ||||||
| WBPaper00061258 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 19 Oct 2021 00:00:00 | ||||||||
| Potential_model | DOID:11984 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7708) | |||||
| DOID:3652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7708) | ||||||
| DOID:2377 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7708) | ||||||
| DOID:655 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7708) | ||||||
| DOID:0112066 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7708) | ||||||
| Models_disease_asserted | WBDOannot00000655 | ||||||||
| WBDOannot00001068 | |||||||||
| WBDOannot00001069 | |||||||||
| WBDOannot00001070 | |||||||||
| WBDOannot00001071 | |||||||||
| Molecular_info | Corresponding_CDS | K09A9.5 | |||||||
| Corresponding_transcript | K09A9.5.1 | ||||||||
| Other_sequence (78) | |||||||||
| Associated_feature | WBsf671384 | ||||||||
| WBsf671385 | |||||||||
| WBsf671386 | |||||||||
| WBsf671387 | |||||||||
| WBsf238335 | |||||||||
| WBsf238336 | |||||||||
| WBsf238337 | |||||||||
| WBsf238338 | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern | Expr1348 | ||||||||
| Expr13130 | |||||||||
| Expr1015145 | |||||||||
| Expr1030915 | |||||||||
| Expr1154073 | |||||||||
| Expr2011948 | |||||||||
| Expr2030185 | |||||||||
| Drives_construct | WBCnstr00010230 | ||||||||
| WBCnstr00036891 | |||||||||
| Construct_product | WBCnstr00036891 | ||||||||
| Regulate_expr_cluster | WBPaper00046217:gas-1(fc21)_downregulated | ||||||||
| WBPaper00046217:gas-1(fc21)_upregulated | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (177) | |||||||||
| Interaction (99) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000077 | |||||||||
| Map_info | Map | X | Position | 22.8752 | Error | 0.00989 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mnDf1 | |||||||
| Positive_clone | K09A9 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | Pos_neg_data | 9392 | |||||||
| Reference (86) | |||||||||
| Method | Gene |
