WormBase Tree Display for WBProcess: WBbiopr:00000001
expand all nodes | collapse all nodes | view schema
| WBbiopr:00000001 | Public_name | Aging | ||||
|---|---|---|---|---|---|---|
| Summary | Aging in C. elegans involves measurable declines in morphology, reproduction, and behavior. Understanding the cellular and molecular processes leading to senescence in this nematode began in the early 1980s with the targeted identification of mutants with extended life spans (an AGE phenotype). These studies identified at least two key regulators of life span, DAF-2, an insulin/IGF receptor ortholog, and DAF-16, a Forkhead-related transcription factor. Since then many more genes and pathways involved in senescence have been identified. Almost all of these genes play important roles in cellular and organismal-level processes other than aging, such as dauer formation, stress response, feeding, and chemosensation. A common marker for aging in C. elegans is the accumulation of lysosomal deposits of lipofuscin, resulting in an increase in intestinal autofluorescence over time. | |||||
| Other_name | Life span determination | |||||
| Ageing | ||||||
| Related_topic | Specialisation_of | WBbiopr:00000041 | ||||
| Taxon | NCBITaxonomyID | 6239 | ||||
| Involved_entity | Gene (102) | |||||
| Expression_cluster (22) | ||||||
| Interaction (511) | ||||||
| Life_stage | WBls:0000023 | Paper_evidence | WBPaper00041045 | |||
| WBls:0000041 | Paper_evidence (47) | |||||
| Molecule | WBMol:00001010 | Paper_evidence | WBPaper00005928 | |||
| WBMol:00001550 | Paper_evidence | WBPaper00005928 | ||||
| WBMol:00001698 | Paper_evidence | WBPaper00035248 | ||||
| WBMol:00002013 | Paper_evidence | WBPaper00046137 | ||||
| WBMol:00002035 | Paper_evidence | WBPaper00046337 | ||||
| WBMol:00002747 | Paper_evidence | WBPaper00005928 | ||||
| WBPaper00046466 | ||||||
| WBMol:00003498 | Paper_evidence | WBPaper00041005 | ||||
| WBMol:00005355 | Paper_evidence | WBPaper00005928 | ||||
| WBMol:00005363 | Paper_evidence | WBPaper00041005 | ||||
| WBMol:00005411 | Paper_evidence | WBPaper00041005 | ||||
| Associated_with | Phenotype (14) | |||||
| GO_term | GO:0008340 | |||||
| GO:0007568 | ||||||
| Pathway | DB_info | Database | WikiPathways | Pathway | WP2313 | |
| Remark | "WikiPathways" "Pathway" "WP2313" | |||||
| Reference (165) |
