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WormBase Tree Display for WBProcess: WBbiopr:00000001

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Name Class

WBbiopr:00000001Public_nameAging
SummaryAging in C. elegans involves measurable declines in morphology, reproduction, and behavior. Understanding the cellular and molecular processes leading to senescence in this nematode began in the early 1980s with the targeted identification of mutants with extended life spans (an AGE phenotype). These studies identified at least two key regulators of life span, DAF-2, an insulin/IGF receptor ortholog, and DAF-16, a Forkhead-related transcription factor. Since then many more genes and pathways involved in senescence have been identified. Almost all of these genes play important roles in cellular and organismal-level processes other than aging, such as dauer formation, stress response, feeding, and chemosensation. A common marker for aging in C. elegans is the accumulation of lysosomal deposits of lipofuscin, resulting in an increase in intestinal autofluorescence over time.
Other_nameLife span determination
Ageing
Related_topicSpecialisation_ofWBbiopr:00000041
TaxonNCBITaxonomyID6239
Involved_entityGene (102)
Expression_cluster (22)
Interaction (511)
Life_stageWBls:0000023Paper_evidenceWBPaper00041045
WBls:0000041Paper_evidence (47)
MoleculeWBMol:00001010Paper_evidenceWBPaper00005928
WBMol:00001550Paper_evidenceWBPaper00005928
WBMol:00001698Paper_evidenceWBPaper00035248
WBMol:00002013Paper_evidenceWBPaper00046137
WBMol:00002035Paper_evidenceWBPaper00046337
WBMol:00002747Paper_evidenceWBPaper00005928
WBPaper00046466
WBMol:00003498Paper_evidenceWBPaper00041005
WBMol:00005355Paper_evidenceWBPaper00005928
WBMol:00005363Paper_evidenceWBPaper00041005
WBMol:00005411Paper_evidenceWBPaper00041005
Associated_withPhenotype (14)
GO_termGO:0008340
GO:0007568
PathwayDB_infoDatabaseWikiPathwaysPathwayWP2313
Remark"WikiPathways" "Pathway" "WP2313"
ReferenceWBPaper00001837
WBPaper00002149
WBPaper00002514
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WBPaper00003173
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WBPaper00005488
WBPaper00005733
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WBPaper00024698
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WBPaper00059947
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WBPaper00060501