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WormBase Tree Display for WBProcess: WBbiopr:00000001

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Name Class

WBbiopr:00000001Public_nameAging
SummaryAging in C. elegans involves measurable declines in morphology, reproduction, and behavior. Understanding the cellular and molecular processes leading to senescence in this nematode began in the early 1980s with the targeted identification of mutants with extended life spans (an AGE phenotype). These studies identified at least two key regulators of life span, DAF-2, an insulin/IGF receptor ortholog, and DAF-16, a Forkhead-related transcription factor. Since then many more genes and pathways involved in senescence have been identified. Almost all of these genes play important roles in cellular and organismal-level processes other than aging, such as dauer formation, stress response, feeding, and chemosensation. A common marker for aging in C. elegans is the accumulation of lysosomal deposits of lipofuscin, resulting in an increase in intestinal autofluorescence over time.
Other_nameLife span determination
Ageing
Related_topicSpecialisation_ofWBbiopr:00000041
TaxonNCBITaxonomyID6239
Involved_entityGene (102)
Expression_clusterWBPaper00028789:pmk-1_downregulatedPaper_evidenceWBPaper00028789
WBPaper00028789:pmk-1_upregulatedPaper_evidenceWBPaper00028789
WBPaper00032062:age_regulated_genesPaper_evidenceWBPaper00032062
WBPaper00032165:A_to_C_transit_decreasedPaper_evidenceWBPaper00032165
WBPaper00032165:A_to_C_transit_increasedPaper_evidenceWBPaper00032165
WBPaper00032165:differentially_expressed_with_age_medoid_1Paper_evidenceWBPaper00032165
WBPaper00032165:differentially_expressed_with_age_medoid_2Paper_evidenceWBPaper00032165
WBPaper00032165:differentially_expressed_with_age_medoid_3Paper_evidenceWBPaper00032165
WBPaper00032165:differentially_expressed_with_age_medoid_4Paper_evidenceWBPaper00032165
WBPaper00032165:differentially_expressed_with_age_medoid_5Paper_evidenceWBPaper00032165
WBPaper00032165:differentially_expressed_with_age_medoid_6Paper_evidenceWBPaper00032165
WBPaper00032165:differentially_expressed_with_age_medoid_7Paper_evidenceWBPaper00032165
WBPaper00036286:Pattern_BPaper_evidenceWBPaper00036286
WBPaper00036286:Pattern_CPaper_evidenceWBPaper00036286
WBPaper00036286:Pattern_DPaper_evidenceWBPaper00036286
WBPaper00036286:Pattern_EPaper_evidenceWBPaper00036286
WBPaper00036286:Pattern_FPaper_evidenceWBPaper00036286
WBPaper00036286:Pattern_GPaper_evidenceWBPaper00036286
WBPaper00036286:Pattern_HPaper_evidenceWBPaper00036286
WBPaper00036286:Pattern_IPaper_evidenceWBPaper00036286
[cgc5976]:class_1Paper_evidenceWBPaper00005976
[cgc5976]:class_2Paper_evidenceWBPaper00005976
Interaction (511)
Life_stageWBls:0000023Paper_evidenceWBPaper00041045
WBls:0000041Paper_evidence (47)
MoleculeWBMol:00001010Paper_evidenceWBPaper00005928
WBMol:00001550Paper_evidenceWBPaper00005928
WBMol:00001698Paper_evidenceWBPaper00035248
WBMol:00002013Paper_evidenceWBPaper00046137
WBMol:00002035Paper_evidenceWBPaper00046337
WBMol:00002747Paper_evidenceWBPaper00005928
WBPaper00046466
WBMol:00003498Paper_evidenceWBPaper00041005
WBMol:00005355Paper_evidenceWBPaper00005928
WBMol:00005363Paper_evidenceWBPaper00041005
WBMol:00005411Paper_evidenceWBPaper00041005
Associated_withPhenotype (14)
GO_termGO:0008340
GO:0007568
PathwayDB_infoDatabaseWikiPathwaysPathwayWP2313
Remark"WikiPathways" "Pathway" "WP2313"
Reference (165)