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WormBase Tree Display for WBProcess: WBbiopr:00000001

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Name Class

WBbiopr:00000001Public_nameAging
SummaryAging in C. elegans involves measurable declines in morphology, reproduction, and behavior. Understanding the cellular and molecular processes leading to senescence in this nematode began in the early 1980s with the targeted identification of mutants with extended life spans (an AGE phenotype). These studies identified at least two key regulators of life span, DAF-2, an insulin/IGF receptor ortholog, and DAF-16, a Forkhead-related transcription factor. Since then many more genes and pathways involved in senescence have been identified. Almost all of these genes play important roles in cellular and organismal-level processes other than aging, such as dauer formation, stress response, feeding, and chemosensation. A common marker for aging in C. elegans is the accumulation of lysosomal deposits of lipofuscin, resulting in an increase in intestinal autofluorescence over time.
Other_nameLife span determination
Ageing
Related_topicSpecialisation_ofWBbiopr:00000041
TaxonNCBITaxonomyID6239
Involved_entityGene (102)
Expression_cluster (22)
Interaction (511)
Life_stageWBls:0000023Paper_evidenceWBPaper00041045
WBls:0000041Paper_evidence (47)
Molecule (10)
Associated_withPhenotype (14)
GO_termGO:0008340
GO:0007568
PathwayDB_infoDatabaseWikiPathwaysPathwayWP2313
Remark"WikiPathways" "Pathway" "WP2313"
Reference (165)