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WormBase Tree Display for Gene: WBGene00001520

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Name Class

WBGene00001520SMapS_parentSequenceK09A9
IdentityVersion3
NameCGC_namegas-1Person_evidenceWBPerson431
Sequence_nameK09A9.5
Molecular_nameK09A9.5
K09A9.5.1
CE11980
Other_namenduf-2.1
ndus-2.1Person_evidenceWBPerson555
CELE_K09A9.5Accession_evidenceNDBBX284606
Public_namegas-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:24WBPerson1971EventImportedInitial conversion from geneace
226 Feb 2008 13:49:33WBPerson2970Name_changeOther_namenduf-2.1
316 Jan 2023 18:37:21WBPerson51134Name_changeOther_namendus-2.1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classgas
Allele (69)
Legacy_information[Morgan PG] fc21 exhibits increased sensitivity to a variety of volatile anesthetics. Also ts lethal, with brood size of 10 - 20 at 25C, 50 - 100 at 20C. fc21/Df almost lethal, brood size 5 - 10. Probable hypomorph. Encodes NADH-ubiquinone reductase. Predicted gene K09A9.5
StrainWBStrain00037441
WBStrain00005211
RNASeq_FPKM (74)
GO_annotation (20)
OrthologWBGene00058668Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00029684Caenorhabditis briggsaeFrom_analysisOrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00108367Pristionchus pacificusFrom_analysisOMA
Inparanoid_8
WormBase-Compara
WBGene00116906Pristionchus pacificusFrom_analysisOMA
Inparanoid_8
WormBase-Compara
WBGene00038858Caenorhabditis briggsaeFrom_analysisOMA
WBGene00055496Caenorhabditis remaneiFrom_analysisOMA
WBGene00143772Caenorhabditis brenneriFrom_analysisOMA
TreeFam
WormBase-Compara
WBGene00121416Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00225204Brugia malayiFrom_analysisWormBase-Compara
WBGene00229906Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g11736Caenorhabditis bovisFrom_analysisWormBase-Compara
CBOVI.g4818Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g4136Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP21.g6393Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g17213Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g20862Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g23107Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g13775Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g13187Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP39.g9060Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g8895Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cnig_chr_X.g25794Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold629.g11161Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00240.g7753Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_01803Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_025518Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g04142Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g21847Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_X0131500Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrX_pilon.g20767Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00241480Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00243256Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00255941Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00287322Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0039331Drosophila melanogasterFrom_analysisEnsEMBL-Compara
OrthoFinder
Panther
FB:FBgn0039909Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-050522-273Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:7708Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:2385112Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1307109Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ParalogWBGene00006463Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
Structured_descriptionConcise_descriptionThe gas-1 gene encodes a 49 kDa subunit of mitochondrial complex I that is required for oxidative phosphorylation, resistance to volatile anesthetics, fecundity, and normal lifespan; gas-1 is expressed in the nematode neuromuscular system; its subcellular distribution appears to be mitochondrial; drug effects on mutants versus wild-type indicate that gas-1 functions at least partially through presynaptic effects; gas-1 mutants have strongly reduced Complex I-dependent metabolism in mitochondria, while Complex II-dependent metabolism is conversely increased in mutants; gas-1 mitochondria look structurally normal.Paper_evidenceWBPaper00004719
WBPaper00028429
Curator_confirmedWBPerson567
Date_last_updated13 Dec 2006 00:00:00
Automated_descriptionPredicted to enable several functions, including 4 iron, 4 sulfur cluster binding activity; NAD binding activity; and NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and response to xenobiotic stimulus. Located in intracellular membrane-bounded organelle. Expressed in anterior gonad arm; body wall musculature; nervous system; non-striated muscle; and tail. Used to study alcohol use disorder and mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in several diseases, including Leigh disease; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Is an ortholog of human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1574Homo sapiensPaper_evidenceWBPaper00005840
Curator_confirmedWBPerson324
Date_last_updated29 Apr 2019 00:00:00
DOID:0060536Homo sapiensPaper_evidenceWBPaper00046523
WBPaper00061258
Curator_confirmedWBPerson324
Date_last_updated19 Oct 2021 00:00:00
Potential_modelDOID:11984Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7708)
DOID:3652Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7708)
DOID:2377Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7708)
DOID:655Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7708)
DOID:0112066Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7708)
Models_disease_assertedWBDOannot00000655
WBDOannot00001068
WBDOannot00001069
WBDOannot00001070
WBDOannot00001071
Molecular_infoCorresponding_CDSK09A9.5
Corresponding_transcriptK09A9.5.1
Other_sequence (78)
Associated_featureWBsf671384
WBsf671385
WBsf671386
WBsf671387
WBsf238335
WBsf238336
WBsf238337
WBsf238338
Experimental_infoRNAi_result (18)
Expr_patternExpr1348
Expr13130
Expr1015145
Expr1030915
Expr1154073
Expr2011948
Expr2030185
Drives_constructWBCnstr00010230
WBCnstr00036891
Construct_productWBCnstr00036891
Regulate_expr_clusterWBPaper00046217:gas-1(fc21)_downregulated
WBPaper00046217:gas-1(fc21)_upregulated
Microarray_results (19)
Expression_cluster (177)
Interaction (99)
WBProcessWBbiopr:00000001
WBbiopr:00000077
Map_infoMapXPosition22.8752Error0.00989
Well_ordered
PositiveInside_rearrmnDf1
Positive_cloneK09A9Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataPos_neg_data9392
Reference (86)
MethodGene