WormBase Tree Display for Gene: WBGene00006942
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| WBGene00006942 | SMap | S_parent | Sequence | F41D9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | wrk-1 | Person_evidence | WBPerson260 | |||||
| Sequence_name | F41D9.3 | ||||||||
| Molecular_name (15) | |||||||||
| Other_name | CELE_F41D9.3 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | wrk-1 | ||||||||
| DB_info | Database | AceView | gene | XJ6 | |||||
| WormQTL | gene | WBGene00006942 | |||||||
| WormFlux | gene | WBGene00006942 | |||||||
| NDB | locus_tag | CELE_F41D9.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006942|UniProtKB=Q5WRR1 | |||||||
| family | PTHR45080 | ||||||||
| NCBI | gene | 181093 | |||||||
| RefSeq | protein | NM_001029478.5 | |||||||
| NM_001029480.6 | |||||||||
| NM_001029477.6 | |||||||||
| NM_001373391.4 | |||||||||
| NM_001029476.4 | |||||||||
| TREEFAM | TREEFAM_ID | TF325699 | |||||||
| TrEMBL | UniProtAcc | H2KZN8 | |||||||
| H2KZN9 | |||||||||
| A0A4V0ING2 | |||||||||
| Q8MPV0 | |||||||||
| Q5WRR1 | |||||||||
| UniProt_GCRP | UniProtAcc | Q5WRR1 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | wrk | ||||||||
| Allele (104) | |||||||||
| Strain (20) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00003971 | ||||||||
| 00003972 | |||||||||
| 00003973 | |||||||||
| 00003974 | |||||||||
| 00003975 | |||||||||
| 00003976 | |||||||||
| 00003977 | |||||||||
| Ortholog (34) | |||||||||
| Paralog | WBGene00004372 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| Structured_description | Concise_description | wrk-1 encodes, by alternative splicing, at least three isoforms of aGPI-anchored immunoglobulin superfamily (IgSF) protein orthologous toDrosophila KLINGON, WRAPPER, CG7166, and CG13506; WRK-1 is expressed inthe pioneering embryonic motoneurons (eMNs) DA, DB, and DD; WRK-1expression in DA, DB, and DD is necessary and sufficient to preventfollower axons from inappropriately crossing the ventral midline; WRK-1also retards developmental changes in the outward current of maturingAIY interneurons; in addition to eMNs and AIY neurons, WRK-1 isexpressed in ASI and SMDV/D neurons, along with sheath and socket cells,intestine, the excretory gland cell, distal tip cells, and coelomocytes;wrk-1 transcription in AIY requires TTX-3, being greatly reduced in attx-3(ot22) mutant background; however, wrk-1 may not betranscriptionally activated by CEH-10/TTX-3 heterodimers, since wrk-1 lacks an AIY motif in its cis-regulatory sequences; WRK-1 binds VAB-1 orVAB-2 in vitro, and wrk-1(ok695) mutations fail to enhance vab-1 or atriple vab-2, efn-2, and efn-3 mutation, indicating that WRK-1 acts in concert with ephrins; wrk-1(ok695) null mutants exhibit midlinecrossover defects in the axons of HSN, PVQ, AV-type, and PVC neurons;wrk-1(ok695) and wrk-1(tm1099) mutant neurons have normal whole cellcapacitance but precociously altered their outward current from a slowlyactivating, sustained current to a rapidly-activating one; hypodermal misexpression of WRK-1 induces defects in PVQ axonal outgrowth, which are enhanced by a wrk-1(ok695) mutant background; wrk-1(ok695) mutationsenhance sax-3(ky123), indicating that WRK-1 and SAX-3 act in parallel. | Paper_evidence | WBPaper00005064 | |||||
| WBPaper00024232 | |||||||||
| WBPaper00027182 | |||||||||
| WBPaper00028566 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 07 Jan 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable axon guidance receptor activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules and synapse organization. Predicted to be located in axon; neuronal cell body; and plasma membrane. Expressed in several structures, including SMDVL; body ganglion; head neurons; hermaphrodite distal tip cell; and interfacial epithelial cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F41D9.3a | |||||||
| F41D9.3b | |||||||||
| F41D9.3c | |||||||||
| F41D9.3e | |||||||||
| F41D9.3f | |||||||||
| Corresponding_CDS_history | F41D9.3d:wp271 | ||||||||
| Corresponding_transcript | F41D9.3a.1 | ||||||||
| F41D9.3b.1 | |||||||||
| F41D9.3c.1 | |||||||||
| F41D9.3e.1 | |||||||||
| F41D9.3f.1 | |||||||||
| Other_sequence | JI167162.1 | ||||||||
| CBC16075_1 | |||||||||
| Acan_isotig08406 | |||||||||
| Tcol_isotig17069 | |||||||||
| Associated_feature (22) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00046984 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00014740 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090689 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1761 | ||||||||
| Expr4281 | |||||||||
| Expr7829 | |||||||||
| Expr8842 | |||||||||
| Expr13214 | |||||||||
| Expr1012620 | |||||||||
| Expr1032956 | |||||||||
| Expr1150847 | |||||||||
| Expr2018072 | |||||||||
| Expr2036210 | |||||||||
| Drives_construct | WBCnstr00001442 | ||||||||
| WBCnstr00001443 | |||||||||
| WBCnstr00001444 | |||||||||
| WBCnstr00001497 | |||||||||
| WBCnstr00001530 | |||||||||
| WBCnstr00013552 | |||||||||
| WBCnstr00034084 | |||||||||
| Construct_product | WBCnstr00001497 | ||||||||
| WBCnstr00006614 | |||||||||
| WBCnstr00034084 | |||||||||
| Microarray_results (43) | |||||||||
| Expression_cluster (185) | |||||||||
| Interaction (21) | |||||||||
| Map_info | Map | X | Position | -0.140944 | Error | 0.004413 | |||
| Positive | Positive_clone | F41D9 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4755 | |||||||
| 4975 | |||||||||
| 5631 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (15) | |||||||||
| Remark | Sequence connection from [Hobert O] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
