WormBase Tree Display for Gene: WBGene00012644
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| WBGene00012644 | SMap | S_parent | Sequence | Y39A1A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | rabx-5 | Person_evidence | WBPerson217 | |||||
| Sequence_name | Y39A1A.5 | ||||||||
| Molecular_name | Y39A1A.5a | ||||||||
| Y39A1A.5a.1 | |||||||||
| CE44298 | |||||||||
| Y39A1A.5b | |||||||||
| CE52961 | |||||||||
| Y39A1A.5b.1 | |||||||||
| Other_name | CELE_Y39A1A.5 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | rabx-5 | ||||||||
| DB_info | Database | AceView | gene | 3L703 | |||||
| WormQTL | gene | WBGene00012644 | |||||||
| WormFlux | gene | WBGene00012644 | |||||||
| NDB | locus_tag | CELE_Y39A1A.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00012644|UniProtKB=Q8I100 | |||||||
| family | PTHR23101 | ||||||||
| NCBI | gene | 176481 | |||||||
| RefSeq | protein | NM_001392197.1 | |||||||
| NM_001372654.2 | |||||||||
| TrEMBL | UniProtAcc | Q8I100 | |||||||
| A0A486WY48 | |||||||||
| UniProt_GCRP | UniProtAcc | A0A486WY48 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:54 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 14 Jan 2005 10:02:14 | WBPerson2970 | Name_change | CGC_name | rabx-5 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rabx | ||||||||
| Allele (206) | |||||||||
| Strain | WBStrain00036476 | ||||||||
| WBStrain00005420 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Contained_in_operon | CEOP3688 | ||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00004377 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00008183 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | rabx-5 encodes a protein containing a zinc-finger domain and a Vps9 domain that is the C. elegans ortholog of the Rabex-5 Rab5 guanine-nucleotide exchange factor (GEF); RABX-5 activity is required for homotypic endosomal fusion, and genetic studies indicate that rabx-5 functions redundantly with rme-6 to regulate RAB-5 localization to endosomes and, more generally, nematode larval development, particularly with respect to regulation of the molting cycle; RABX-5 physically interacts with RABN-5, the C. elegans ortholog of Rabaptin-5, a Rab5 effector protein and with the RAB-5 GTPase (likely the GDP-bound form). | Paper_evidence | WBPaper00025193 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 24 Aug 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in endosomal vesicle fusion and molting cycle. Located in early endosome. Expressed in several structures, including coelomocyte; distal tip cell; neurons; ventral nerve cord; and vulva. Is an ortholog of human RABGEF1 (RAB guanine nucleotide exchange factor 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y39A1A.5a | |||||||
| Y39A1A.5b | |||||||||
| Corresponding_CDS_history | Y39A1A.5:wp209 | ||||||||
| Y39A1A.5a:wp90 | |||||||||
| Y39A1A.5b:wp90 | |||||||||
| Corresponding_transcript | Y39A1A.5a.1 | ||||||||
| Y39A1A.5b.1 | |||||||||
| Other_sequence (36) | |||||||||
| Associated_feature | WBsf659519 | ||||||||
| WBsf717105 | |||||||||
| WBsf225738 | |||||||||
| Transcription_factor | WBTranscriptionFactor000859 | ||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr15223 | ||||||||
| Expr1011095 | |||||||||
| Expr1035585 | |||||||||
| Expr1159632 | |||||||||
| Expr2015235 | |||||||||
| Expr2033469 | |||||||||
| Drives_construct | WBCnstr00042079 | ||||||||
| Construct_product | WBCnstr00042080 | ||||||||
| Antibody | WBAntibody00000924 | ||||||||
| Microarray_results (42) | |||||||||
| Expression_cluster (129) | |||||||||
| Interaction (33) | |||||||||
| Map_info | Map | III | Position | 3.91443 | Error | 0.034863 | |||
| Positive | Positive_clone | Y39A1A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4323 | |||||||
| 5025 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (15) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
