WormBase Tree Display for Gene: WBGene00003405
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| WBGene00003405 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | ZC302 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | mre-11 | Person_evidence | WBPerson1547 | |||||
| Sequence_name | ZC302.1 | ||||||||
| Molecular_name | ZC302.1 | ||||||||
| ZC302.1.1 | |||||||||
| CE37459 | |||||||||
| ZC302.1.2 | |||||||||
| Other_name | CELE_ZC302.1 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | mre-11 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mre | ||||||||
| Allele (51) | |||||||||
| Legacy_information | [Chin G, Villeneuve AM] me41 homozyotes are viable hermaphrodite, morphologically normal;98% of eggs fail to hatch, Him: 24% of viable progeny are male. Defective in meiotic recombination and chiasma formation, radiation-induced chromosome damage, but not in DNA-damage-induced apoptosis. ok179 similar. Encoding ortholog of budding yeast Mre11p | ||||||||
| Strain | WBStrain00000278 | ||||||||
| WBStrain00034461 | |||||||||
| WBStrain00034465 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (29) | |||||||||
| Ortholog (37) | |||||||||
| Structured_description | Concise_description | mre-11 encodes a protein orthologous to S. cerevisiae MRE11 and to human MRE11A (OMIM:600814, mutated in ataxia-telangiectasia-like disorder); MRE-11 is required for meiotic recombination and DNA repair in C. elegans, for multigenerational persistence of the germline, and (in conjunction with CHK-2 and SPO-11) for the localization of RAD-51 to foci in late zygotene/early pachytene nuclei. | Paper_evidence | WBPaper00004596 | |||||
| WBPaper00006010 | |||||||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in DNA damage response and nucleic acid metabolic process. Located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lynch syndrome; endometrial cancer; and gastrointestinal system cancer (multiple). Is an ortholog of human MRE11 (MRE11 homolog, double strand break repair nuclease). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7230) | ||||
| DOID:5517 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7230) | ||||||
| DOID:3883 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7230) | ||||||
| DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7230) | ||||||
| DOID:219 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7230) | ||||||
| DOID:3459 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7230) | ||||||
| DOID:3069 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7230) | ||||||
| DOID:1993 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7230) | ||||||
| DOID:0081384 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7230) | ||||||
| DOID:1380 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7230) | ||||||
| Molecular_info | Corresponding_CDS | ZC302.1 | |||||||
| Corresponding_CDS_history | ZC302.1:wp131 | ||||||||
| Corresponding_transcript | ZC302.1.1 | ||||||||
| ZC302.1.2 | |||||||||
| Other_sequence (17) | |||||||||
| Associated_feature | WBsf653030 | ||||||||
| WBsf234429 | |||||||||
| WBsf234430 | |||||||||
| WBsf234431 | |||||||||
| WBsf234432 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr8045 | ||||||||
| Expr10152 | |||||||||
| Expr13767 | |||||||||
| Expr1024900 | |||||||||
| Expr1031574 | |||||||||
| Expr1162262 | |||||||||
| Expr2013684 | |||||||||
| Expr2031919 | |||||||||
| Drives_construct | WBCnstr00014719 | ||||||||
| WBCnstr00036135 | |||||||||
| Construct_product | WBCnstr00014719 | ||||||||
| WBCnstr00036135 | |||||||||
| Antibody | WBAntibody00001375 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (160) | |||||||||
| Interaction (288) | |||||||||
| Map_info | Map | V | Position | 2.75059 | Error | 0.003337 | |||
| Positive | Positive_clone | ZC302 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4028 | |||||||
| 4554 | |||||||||
| Reference (50) | |||||||||
| Remark | sequence connection from [Villeneuve AM] | ||||||||
| Sequence connection from [Boulton S, Vidal M] | |||||||||
| Data extracted (JAH) from Chin & Villeneuve (2001) | |||||||||
| Positive_clone is based on mutant sequence [Chin G, Villeneuve AM] [030403 ck1] | |||||||||
| Method | Gene |
