WormBase Tree Display for Gene: WBGene00000275
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| WBGene00000275 | SMap | S_parent | Sequence | R06C7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | bub-1 | Person_evidence | WBPerson283 | |||||
| Sequence_name | R06C7.8 | ||||||||
| Molecular_name | R06C7.8 | ||||||||
| R06C7.8.1 | |||||||||
| CE06251 | |||||||||
| Other_name | CELE_R06C7.8 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | bub-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | bub | ||||||||
| Allele (50) | |||||||||
| Strain | WBStrain00037468 | ||||||||
| WBStrain00034954 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (56) | |||||||||
| Ortholog (50) | |||||||||
| Paralog | WBGene00004721 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | bub-1 encodes a serine/threonine kinase orthologous to Saccharomyces cerevisiae BUB1 which is required for proper function of the mitotic spindle assembly checkpoint and human BUB1 (OMIM:602452) which is mutated in some colorectal cancers; BUB-1 activity is required at several stages of development, including embryogenesis; BUB-1 is expressed predominantly in the anterior of the embryo and in hypodermal seam cells during the L1 and L2 larval stages. | Paper_evidence | WBPaper00004540 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables kinetochore binding activity. Involved in several processes, including meiotic cell cycle; positive regulation of nematode male tail tip morphogenesis; and protein localization to kinetochore involved in kinetochore assembly. Located in kinetochore. Expressed in seam cell. Human ortholog(s) of this gene implicated in colorectal cancer and primary autosomal recessive microcephaly. Is an ortholog of human BUB1 (BUB1 mitotic checkpoint serine/threonine kinase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1148) | ||||
| DOID:0070296 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1148) | ||||||
| Molecular_info | Corresponding_CDS | R06C7.8 | |||||||
| Corresponding_transcript | R06C7.8.1 | ||||||||
| Other_sequence (29) | |||||||||
| Associated_feature | WBsf643439 | ||||||||
| WBsf643440 | |||||||||
| WBsf656502 | |||||||||
| WBsf656503 | |||||||||
| WBsf217980 | |||||||||
| Experimental_info | RNAi_result (35) | ||||||||
| Expr_pattern | Expr175 | ||||||||
| Expr8722 | |||||||||
| Expr8723 | |||||||||
| Expr1016452 | |||||||||
| Expr1030179 | |||||||||
| Expr1155080 | |||||||||
| Expr1200209 | |||||||||
| Expr2009680 | |||||||||
| Expr2027919 | |||||||||
| Drives_construct (14) | |||||||||
| Construct_product (15) | |||||||||
| Antibody | WBAntibody00000378 | ||||||||
| WBAntibody00002508 | |||||||||
| WBAntibody00002845 | |||||||||
| WBAntibody00002926 | |||||||||
| WBAntibody00002932 | |||||||||
| WBAntibody00002970 | |||||||||
| WBAntibody00003059 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (177) | |||||||||
| Interaction (212) | |||||||||
| Map_info | Map | I | Position | 1.86187 | Error | 0.001201 | |||
| Positive | Positive_clone | R06C7 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (45) | |||||||||
| Remark | Sequence connection from [Oegema K, Hyman AA] [040902 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
