WormBase Tree Display for Gene: WBGene00002982

WBGene00002982 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: B0336
  Identity: Version: 2
    Name: CGC_name: lgg-3 Person_evidence: WBPerson321
      Sequence_name: B0336.8
      Molecular_name: B0336.8
        B0336.8.1
        CE00776
      Other_name: atg-12 Paper_evidence: WBPaper00028973
          Person_evidence: WBPerson649
        CELE_B0336.8 Accession_evidence: NDB BX284603
      Public_name: lgg-3
    DB_info: Database: AceView gene 3G786
        WormQTL gene WBGene00002982
        WormFlux gene WBGene00002982
        NDB locus_tag CELE_B0336.8
        Panther gene CAEEL|WormBase=WBGene00002982|UniProtKB=Q10931
          family PTHR13385
        NCBI gene 175793
        RefSeq protein NM_065827.3
        SwissProt UniProtAcc Q10931
        TREEFAM TREEFAM_ID TF325131
        UniProt_GCRP UniProtAcc Q10931
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 15 Mar 2007 08:30:58 WBPerson2970 Name_change: Other_name: atg-12
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lgg
    Allele: WBVar00250621
      WBVar01500260
      WBVar01500122
      WBVar01500123
      WBVar00829183
      WBVar00829184
      WBVar00829185
      WBVar00275641
      WBVar02053280
    RNASeq_FPKM (74)
    GO_annotation (16)
    Contained_in_operon: CEOP3324
    Ortholog (34)
    Structured_description: Concise_description: lgg-3 encodes a hydrophilic protein that is orthologous to Saccharomyces cerevisiae autophagy protein Apg12p; by homology, LGG-3 is predicted to function as a modifier protein required for a protein conjugation system essential for autophagy; in the context of this conjugation system, LGG-3 is predicted to interact with Apg7p and Apg5p homologs (encoded by M7.5 and Y71G12B.12a, respectively) to effect bulk degradation of cytoplasmic components under conditions of starvation or cellular remodeling; free LGG-3 is predicted to localize to the cytoplasm, while LGG-3 conjugated to the Apg5p homolog is predicted to associate with membrane compartments; loss of lgg-3 activity via large-scale RNAi screens results in no obvious developmental or behavioral abnormalities. Paper_evidence: WBPaper00004403
            WBPaper00005654
            WBPaper00013631
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Involved in cellular response to toxic substance; determination of adult lifespan; and xenophagy. Acts upstream of or within with a positive effect on plasma membrane repair. Located in autophagosome membrane. Is an ortholog of human ATG12 (autophagy related 12). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: B0336.8
    Corresponding_transcript: B0336.8.1
    Associated_feature: WBsf651070
      WBsf655435
  Experimental_info: RNAi_result (34)
    Expr_pattern: Expr1014494
      Expr1031382
      Expr1143130
      Expr2013144
      Expr2031376
    Drives_construct: WBCnstr00036307
    Construct_product: WBCnstr00036307
    Antibody: WBAntibody00002571
    Microarray_results (16)
    Expression_cluster (105)
    Interaction (26)
  Map_info: Map: III Position: -1.45276 Error: 0.000601
    Positive: Positive_clone: B0336 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (17)
  Remark: Sequence connection from [Kimura Y]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene