WormBase Tree Display for Gene: WBGene00004759
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| WBGene00004759 | SMap | S_parent | Sequence | F45D3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sel-1 | Person_evidence | WBPerson220 | |||||
| Sequence_name | F45D3.5 | ||||||||
| Molecular_name | F45D3.5 | ||||||||
| F45D3.5.1 | |||||||||
| CE16043 | |||||||||
| Other_name | sup-25 | ||||||||
| CELE_F45D3.5 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | sel-1 | ||||||||
| DB_info | Database | AceView | gene | 5N43 | |||||
| WormQTL | gene | WBGene00004759 | |||||||
| WormFlux | gene | WBGene00004759 | |||||||
| NDB | locus_tag | CELE_F45D3.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004759|UniProtKB=G5EFG0 | |||||||
| family | PTHR11102 | ||||||||
| NCBI | gene | 179720 | |||||||
| RefSeq | protein | NM_073743.8 | |||||||
| TREEFAM | TREEFAM_ID | TF315257 | |||||||
| TrEMBL | UniProtAcc | G5EFG0 | |||||||
| UniProt_GCRP | UniProtAcc | G5EFG0 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sel | ||||||||
| Allele (59) | |||||||||
| Legacy_information | [Sundaram M] e1948 recessive suppressor of lin-12 hypomorph, and partial suppressor of glp-1 hypomorph; no effect on lin-12 amorph; no phenotype alone. NA5 (ar23, ar29, ar73, ar77) | ||||||||
| [C.elegansII] e1948 : pka sup-25, recessive suppressor of lin-12h hypomorph(n676n930ts), and partial suppressor of glp-1 hypomorph; no effect on lin-12 amorph; no phenotype alone. No suppression of lin-3, egl-15, etc.OA4: ar23, ar29, ar73, ar77. Cloned: encodes predicted 650 aa protein with signal sequence. [Sundaram and Greenwald 1993; GS] | |||||||||
| Strain | WBStrain00007964 | ||||||||
| WBStrain00008019 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Contained_in_operon | CEOP5356 | ||||||||
| Ortholog (41) | |||||||||
| Structured_description | Concise_description | sel-1 encodes two isoforms of a highly conserved transmembrane protein orthologous to human SEL1 (OMIM:602329) and Saccharomyces cerevisiae HRD3, a member of the HMG-CoA Reductase Degradation (HRD) complex that degrades malfolded endoplasmic reticulum (ER)-resident proteins; SEL-1 functions as a negative regulator of the LIN-12/GLP-1 Notch-like signaling pathway in C. elegans where it appears to function cell autonomously to regulate LIN-12 turnover; along with ABU-1, an ER-associated Type I transmembrane protein, SEL-1 may be a component of a cell survival pathway induced when unfolded proteins accumulate in the ER; SEL-1 is expressed throughout larval and adult stages of development, and detected in all tissues except the pharynx; within cells, SEL-1 appears to localize to intracellular vesicles, consistent with its proposed role in protein turnover. | Paper_evidence | WBPaper00001828 | |||||
| WBPaper00002660 | |||||||||
| WBPaper00005432 | |||||||||
| WBPaper00013109 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 08 Dec 2005 00:00:00 | ||||||||
| Automated_description | Predicted to contribute to ubiquitin-protein transferase activity. Involved in negative regulation of Notch signaling pathway. Located in cytoplasmic vesicle. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P7.p hermaphrodite; and P8.p hermaphrodite. Human ortholog(s) of this gene implicated in pancreatic cancer. Is an ortholog of human SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10717) | ||||
| Molecular_info | Corresponding_CDS | F45D3.5 | |||||||
| Corresponding_transcript | F45D3.5.1 | ||||||||
| Other_sequence (43) | |||||||||
| Associated_feature | WBsf647384 | ||||||||
| WBsf718427 | |||||||||
| WBsf232668 | |||||||||
| WBsf232669 | |||||||||
| Experimental_info | RNAi_result (21) | ||||||||
| Expr_pattern | Expr549 | ||||||||
| Expr781 | |||||||||
| Expr1028471 | |||||||||
| Expr1032355 | |||||||||
| Expr1151232 | |||||||||
| Expr2015732 | |||||||||
| Expr2033965 | |||||||||
| Drives_construct | WBCnstr00000043 | ||||||||
| WBCnstr00007594 | |||||||||
| WBCnstr00012432 | |||||||||
| WBCnstr00035405 | |||||||||
| WBCnstr00043028 | |||||||||
| Construct_product | WBCnstr00001407 | ||||||||
| WBCnstr00007594 | |||||||||
| WBCnstr00012432 | |||||||||
| WBCnstr00017651 | |||||||||
| WBCnstr00035405 | |||||||||
| WBCnstr00042674 | |||||||||
| WBCnstr00043028 | |||||||||
| Antibody | WBAntibody00000140 | ||||||||
| WBAntibody00003044 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (83) | |||||||||
| Interaction (78) | |||||||||
| WBProcess | WBbiopr:00000046 | ||||||||
| WBbiopr:00000076 | |||||||||
| Map_info | Map | V | Position | 4.49847 | Error | 0.007514 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C06C11 | |||||||
| F45D3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 1531 | |||||||
| 1532 | |||||||||
| 2797 | |||||||||
| 2798 | |||||||||
| 4374 | |||||||||
| Reference (50) | |||||||||
| Remark | from Sundaram & Greenwald 1993 | ||||||||
| Method | Gene |
