| WBGene00004759 | SMap | S_parent | Sequence | F45D3 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | sel-1 | Person_evidence | WBPerson220 |
| | | Sequence_name | F45D3.5 |
| | | Molecular_name | F45D3.5 |
| | | | F45D3.5.1 |
| | | | CE16043 |
| | | Other_name | sup-25 |
| | | | CELE_F45D3.5 | Accession_evidence | NDB | BX284605 |
| | | Public_name | sel-1 |
| | DB_info | Database | AceView | gene | 5N43 |
| | | | WormQTL | gene | WBGene00004759 |
| | | | WormFlux | gene | WBGene00004759 |
| | | | NDB | locus_tag | CELE_F45D3.5 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00004759|UniProtKB=G5EFG0 |
| | | | | family | PTHR11102 |
| | | | NCBI | gene | 179720 |
| | | | RefSeq | protein | NM_073743.8 |
| | | | TREEFAM | TREEFAM_ID | TF315257 |
| | | | TrEMBL | UniProtAcc | G5EFG0 |
| | | | UniProt_GCRP | UniProtAcc | G5EFG0 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | sel |
| | Allele (59) |
| | Legacy_information | [Sundaram M] e1948 recessive suppressor of lin-12 hypomorph, and partial suppressor of glp-1 hypomorph; no effect on lin-12 amorph; no phenotype alone. NA5 (ar23, ar29, ar73, ar77) |
| | | [C.elegansII] e1948 : pka sup-25, recessive suppressor of lin-12h hypomorph(n676n930ts), and partial suppressor of glp-1 hypomorph; no effect on lin-12 amorph; no phenotype alone. No suppression of lin-3, egl-15, etc.OA4: ar23, ar29, ar73, ar77. Cloned: encodes predicted 650 aa protein with signal sequence. [Sundaram and Greenwald 1993; GS] |
| | Strain | WBStrain00007964 |
| | | WBStrain00008019 |
| | RNASeq_FPKM (74) |
| | GO_annotation (11) |
| | Contained_in_operon | CEOP5356 |
| | Ortholog (41) |
| | Structured_description | Concise_description | sel-1 encodes two isoforms of a highly conserved transmembrane protein orthologous to human SEL1 (OMIM:602329) and Saccharomyces cerevisiae HRD3, a member of the HMG-CoA Reductase Degradation (HRD) complex that degrades malfolded endoplasmic reticulum (ER)-resident proteins; SEL-1 functions as a negative regulator of the LIN-12/GLP-1 Notch-like signaling pathway in C. elegans where it appears to function cell autonomously to regulate LIN-12 turnover; along with ABU-1, an ER-associated Type I transmembrane protein, SEL-1 may be a component of a cell survival pathway induced when unfolded proteins accumulate in the ER; SEL-1 is expressed throughout larval and adult stages of development, and detected in all tissues except the pharynx; within cells, SEL-1 appears to localize to intracellular vesicles, consistent with its proposed role in protein turnover. | Paper_evidence | WBPaper00001828 |
| | | | | | WBPaper00002660 |
| | | | | | WBPaper00005432 |
| | | | | | WBPaper00013109 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 08 Dec 2005 00:00:00 |
| | | Automated_description | Predicted to contribute to ubiquitin-protein transferase activity. Involved in negative regulation of Notch signaling pathway. Located in cytoplasmic vesicle. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P7.p hermaphrodite; and P8.p hermaphrodite. Human ortholog(s) of this gene implicated in pancreatic cancer. Is an ortholog of human SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:1793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10717) |
| Molecular_info | Corresponding_CDS | F45D3.5 |
| | Corresponding_transcript | F45D3.5.1 |
| | Other_sequence (43) |
| | Associated_feature | WBsf647384 |
| | | WBsf718427 |
| | | WBsf232668 |
| | | WBsf232669 |
| Experimental_info | RNAi_result (21) |
| | Expr_pattern | Expr549 |
| | | Expr781 |
| | | Expr1028471 |
| | | Expr1032355 |
| | | Expr1151232 |
| | | Expr2015732 |
| | | Expr2033965 |
| | Drives_construct | WBCnstr00000043 |
| | | WBCnstr00007594 |
| | | WBCnstr00012432 |
| | | WBCnstr00035405 |
| | | WBCnstr00043028 |
| | Construct_product | WBCnstr00001407 |
| | | WBCnstr00007594 |
| | | WBCnstr00012432 |
| | | WBCnstr00017651 |
| | | WBCnstr00035405 |
| | | WBCnstr00042674 |
| | | WBCnstr00043028 |
| | Antibody | WBAntibody00000140 |
| | | WBAntibody00003044 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061527:cids-2_2203-attf-2_2451 |
| | | WBPaper00061527:lpd-3-F54B3.1_21769 |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064130:Beta-Amyloid_upregulated_protein |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | cgc4489_group_3 |
| | | WBPaper00005124:cholesterol_10-9M_regulated |
| | | WBPaper00025032:cluster_3 |
| | | WBPaper00025032:cluster_21 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00041002:HF_3d_0.2mM_Down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00055899:nitroguanidine_regulated |
| | | [cgc5767]:cluster_3 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MD_pd(66_min) |
| | | [cgc5767]:expression_class_SM |
| | | [cgc5767]:expression_class_SMD |
| | | [cgc6390]:herm_sex-enriched |
| | Interaction (78) |
| | WBProcess | WBbiopr:00000046 |
| | | WBbiopr:00000076 |
| Map_info | Map | V | Position | 4.49847 | Error | 0.007514 |
| | Well_ordered |
| | Positive | Positive_clone | C06C11 |
| | | | F45D3 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 1531 |
| | | | 1532 |
| | | | 2797 |
| | | | 2798 |
| | | | 4374 |
| Reference (50) |
| Remark | from Sundaram & Greenwald 1993 |
| Method | Gene |
