WormBase Tree Display for Gene: WBGene00000939
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| WBGene00000939 | Evidence | Paper_evidence | WBPaper00004772 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | K12H4 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | dcr-1 | Person_evidence | WBPerson419 | |||||
| Sequence_name | K12H4.8 | ||||||||
| Molecular_name | K12H4.8 | ||||||||
| K12H4.8.1 | |||||||||
| CE47418 | |||||||||
| Other_name | let-740 | CGC_data_submission | |||||||
| eri-4 | Paper_evidence | WBPaper00035199 | |||||||
| CELE_K12H4.8 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | dcr-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dcr | ||||||||
| Allele (78) | |||||||||
| Legacy_information | Homozygous s2624 and s2795 each develope into sterile adults. | ||||||||
| Strain (13) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (61) | |||||||||
| Ortholog (58) | |||||||||
| Paralog | WBGene00001090 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WBGene00008400 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Structured_description | Concise_description | dcr-1 encodes a bidentate ribonuclease that is homologous to E. coli RNAse III; DCR-1 is required both for RNA interference and for synthesis of small developmental RNAs; DCR-1 functions to process pre-miRNAs into their mature, 22-nt form; DCR-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to DCR-1 for endonucleolytic processing; DCR-1 is also required for fragmention of chromosomal DNA during apoptosis, and undergoes a CED-3 protease-mediated conversion from a ribonuclease to a deoxyribonuclease. | Paper_evidence | WBPaper00004424 | |||||
| WBPaper00004923 | |||||||||
| WBPaper00005368 | |||||||||
| WBPaper00036025 | |||||||||
| WBPaper00024573 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 03 Feb 2014 00:00:00 | ||||||||
| Automated_description | Enables deoxyribonuclease I activity and ribonuclease III activity. Involved in several processes, including nucleic acid metabolic process; olfactory learning; and positive regulation of primary miRNA processing. Acts upstream of or within defense response to Gram-positive bacterium. Located in cytosol and nucleus. Expressed in germ line; intestine; neurons; and somatic cell. Human ortholog(s) of this gene implicated in several diseases, including DICER1 syndrome; gastrointestinal system cancer (multiple); and multinodular goiter. Is an ortholog of human DICER1 (dicer 1, ribonuclease III). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||
| DOID:4769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||||
| DOID:0050745 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||||
| DOID:0080615 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||||
| DOID:0050489 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||||
| DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||||
| DOID:0081063 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||||
| Molecular_info | Corresponding_CDS | K12H4.8 | |||||||
| Corresponding_CDS_history | K12H4.8:wp230 | ||||||||
| Corresponding_transcript | K12H4.8.1 | ||||||||
| Other_sequence (58) | |||||||||
| Associated_feature | WBsf651241 | ||||||||
| WBsf667129 | |||||||||
| WBsf227077 | |||||||||
| WBsf227078 | |||||||||
| Experimental_info | RNAi_result (65) | ||||||||
| Expr_pattern | Expr10581 | ||||||||
| Expr11565 | |||||||||
| Expr12215 | |||||||||
| Expr12472 | |||||||||
| Expr1022725 | |||||||||
| Expr1030586 | |||||||||
| Expr1154395 | |||||||||
| Expr2010807 | |||||||||
| Expr2029044 | |||||||||
| Drives_construct | WBCnstr00005999 | ||||||||
| WBCnstr00006000 | |||||||||
| WBCnstr00006001 | |||||||||
| WBCnstr00017007 | |||||||||
| WBCnstr00020414 | |||||||||
| WBCnstr00037186 | |||||||||
| Construct_product (13) | |||||||||
| Regulate_expr_cluster | WBPaper00027057:DCR-1_interacting_adult | ||||||||
| WBPaper00027057:DCR-1_interacting_embryo | |||||||||
| WBPaper00029437:dcr-1_downregulated | |||||||||
| WBPaper00029437:dcr-1_upregulated | |||||||||
| WBPaper00059490:dcr-1(m9375)_downregulated | |||||||||
| WBPaper00059490:dcr-1(m9375)_upregulated | |||||||||
| Antibody | WBAntibody00000418 | ||||||||
| WBAntibody00001054 | |||||||||
| WBAntibody00001326 | |||||||||
| WBAntibody00001327 | |||||||||
| WBAntibody00001490 | |||||||||
| WBAntibody00002257 | |||||||||
| WBAntibody00002600 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (137) | |||||||||
| Interaction (219) | |||||||||
| WBProcess | WBbiopr:00000014 | ||||||||
| WBbiopr:00000039 | |||||||||
| WBbiopr:00000057 | |||||||||
| WBbiopr:00000073 | |||||||||
| WBbiopr:00000081 | |||||||||
| Map_info | Map | III | Position | -0.385999 | Error | 0.003601 | |||
| Hide_under | WBGene00002843 | ||||||||
| Positive | Inside_rearr | nDf20 | |||||||
| sDp3 | |||||||||
| sDp8 | |||||||||
| Positive_clone | K12H4 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Negative | Outside_rearr | sDf128 | |||||||
| Mapping_data | Multi_point | 5311 | |||||||
| Pos_neg_data | 9651 | ||||||||
| 9674 | |||||||||
| 9694 | |||||||||
| 9695 | |||||||||
| 9715 | |||||||||
| Reference (124) | |||||||||
| Remark | The let-740 gene is the same gene as dcr-1 and they therefore have been merged following advice from the CGC. let-740 is now an other name for dcr-1 [krb 030508] | ||||||||
| Method | Gene |
