WormBase Tree Display for WBProcess: WBbiopr:00000073
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| WBbiopr:00000073 | Public_name | Wnt signaling pathway | |||
|---|---|---|---|---|---|
| Summary | Wnt glycoproteins are signaling molecules that control a wide range of developmental processes and is a conserved feature of metazoan development. In C. elegans Wnt signaling has been shown to play a role in cell fate specification and determination of cell polarity, cell migration, and axis determination during axon outgrowth. A 'canonical' Wnt signaling pathway has been elucidated in vertebrate and invertebrate model systems where Wnt binding leads to the stabilization of the transcription factor beta-catenin, which then enters the nucleus to regulate Wnt pathway target genes. Like other species, the C. elegans genome encodes multiple genes for Wnt ligands, EGL-20, LIN-44, MOM-2, CWN-1, CWN-2) and Wnt receptors (LIN-17, MOM-5, MIG-1, CFZ-2, LIN-18). Canonical Wnt signaling in C. elegans, utilizes the beta-catenin BAR-1 to convert POP-1 into an activator and controls the expression of several homeobox genes. However, unlike vertebrates or Drosophila, the C. elegans genome encodes multiple beta-catenin genes (HMP-2, BAR-1, SYS-1, WRM-1), which give rise to noncanonical Wnt signalling pathways: for example, the endoderm induction pathway requires the beta-catenin WRM-1 and parallel input from a mitogen-activated kinase (MAPK) pathway to downregulate POP-1. | ||||
| Other_name | Wnt signalling pathway | ||||
| Related_topic | Specialisation_of | WBbiopr:00000020 | |||
| WBbiopr:00000024 | |||||
| WBbiopr:00000094 | |||||
| WBbiopr:00000112 | |||||
| WBbiopr:00000107 | |||||
| WBbiopr:00000110 | |||||
| WBbiopr:00000114 | |||||
| Involved_entity | Gene (46) | ||||
| Interaction (66) | |||||
| Anatomy_term (15) | |||||
| Associated_with | Phenotype | WBPhenotype:0000104 | Paper_evidence | WBPaper00027192 | |
| GO_term | GO:0016055 | ||||
| GO:0060070 | |||||
| Picture (17) | |||||
| Reference (302) |
