WormBase Tree Display for WBProcess: WBbiopr:00000020
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| WBbiopr:00000020 | Public_name | Vulval development | ||||
|---|---|---|---|---|---|---|
| Summary | The C. elegans vulva connects the hermaphrodite uterus to the outside of the nematode. The development of this organ is an intensively studied biological process making it a useful model for animal organogenesis. C. elegans vulval development involves the temporal and spatial coordination of intercellular signaling, evolutionarily conserved signal transduction pathways, and transcriptional regulation. Among the pathways involved in vulval development are the WNT, epidermal growth factor (EGF), and LIN-12/NOTCH signaling pathways. These pathways work in temporal succession to prime epidermal cells to first be competent to take on vulva cell fates and later to solidify their vulval cell specification. These pathways also work antagonistically to specify the precise pattern of cell fates needed to form the vulva. A key cell in vulval development is the anchor cell. Signals from this cell initiate the transition from epidermal to vulval precursor cell. This cell also influences the specification of surrounding uterine cells, which is required to connect the uterus to the vulva. The development of the final vulval organ requires the anchor cell to invade between terminally differentiated vulval cells in a behavior analogous to that of metastatic tumor cells. | |||||
| Related_topic | Specialisation_of | WBbiopr:00000034 | ||||
| Generalisation_of | WBbiopr:00000073 | |||||
| WBbiopr:00000070 | ||||||
| WBbiopr:00000072 | ||||||
| Involved_entity | Gene (17) | |||||
| Expression_cluster | [cgc5376]:let-60(G12V)-regulated_genes | Paper_evidence | WBPaper00005376 | |||
| Interaction (134) | ||||||
| Anatomy_term (22) | ||||||
| Life_stage | WBls:0000024 | Paper_evidence | WBPaper00027316 | |||
| WBls:0000027 | Paper_evidence | WBPaper00027316 | ||||
| Associated_with | Phenotype (12) | |||||
| GO_term | GO:0040025 | |||||
| GO:0072325 | ||||||
| GO:0072326 | ||||||
| GO:0072327 | ||||||
| GO:0040028 | ||||||
| GO:0040026 | ||||||
| GO:0040027 | ||||||
| Picture | WBPicture0000012992 | |||||
| WBPicture0000013092 | ||||||
| Pathway | DB_info | Database | WikiPathways | Pathway | WP1453 | |
| WP2221 | ||||||
| WP2569 | ||||||
| Remark | "WikiPathways" "Pathway" "WP1453" | "WikiPathways" "Pathway" "WP2221" | |||||
| Reference (12) |
