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| WBPicture0000013092 | Description | Figure 7: ERK converts LIN-1 from a SUMOylated transcriptional repressor to a phosphorylated transcriptional activator. A model for the regulation of vulval cell fates by LIN-1. LIN-1 represses 1 vulval cell fate genes by recruiting RAD-26 and MEP-1 to its SUMOylated amino-terminus and EGL-27 to its unSUMOylated carboxy-terminus. RAD-26 remodels nucleosomes, and EGL-27 and MEP-1 facilitate histone deacetylation through their association with HDAC-1 and HDAC-2. Following activation of the EGFR/Ras/MAPK pathway in P6.p, ERK converts LIN-1 to a phosphorylated transcriptional activator of 1 vulval cell fate genes. | |||
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| Name | Fig7.jpg | ||||
| Depict | WBProcess | WBbiopr:00000024 | |||
| WBbiopr:00000020 | |||||
| Gene | WBGene00007761 | ||||
| WBGene00003218 | |||||
| WBGene00002990 | |||||
| WBGene00001194 | |||||
| Acknowledgment | Template | WormBase thanks the journal <Journal_URL> for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Reprinted from <Journal_URL>, <Article_URL>. Copyright (<Publication_year>) with permission from <Publisher_URL> | |||
| Publication_year | 2015 | ||||
| Article_URL | DOI | id | 10.1534/genetics.114.172668 | ||
| Journal_URL | Genetics | ||||
| Publisher_URL | GSA | ||||
| Reference | WBPaper00046298 |
