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WormBase Tree Display for WBProcess: WBbiopr:00000073

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Name Class

WBbiopr:00000073Public_nameWnt signaling pathway
SummaryWnt glycoproteins are signaling molecules that control a wide range of developmental processes and is a conserved feature of metazoan development. In C. elegans Wnt signaling has been shown to play a role in cell fate specification and determination of cell polarity, cell migration, and axis determination during axon outgrowth. A 'canonical' Wnt signaling pathway has been elucidated in vertebrate and invertebrate model systems where Wnt binding leads to the stabilization of the transcription factor beta-catenin, which then enters the nucleus to regulate Wnt pathway target genes. Like other species, the C. elegans genome encodes multiple genes for Wnt ligands, EGL-20, LIN-44, MOM-2, CWN-1, CWN-2) and Wnt receptors (LIN-17, MOM-5, MIG-1, CFZ-2, LIN-18). Canonical Wnt signaling in C. elegans, utilizes the beta-catenin BAR-1 to convert POP-1 into an activator and controls the expression of several homeobox genes. However, unlike vertebrates or Drosophila, the C. elegans genome encodes multiple beta-catenin genes (HMP-2, BAR-1, SYS-1, WRM-1), which give rise to noncanonical Wnt signalling pathways: for example, the endoderm induction pathway requires the beta-catenin WRM-1 and parallel input from a mitogen-activated kinase (MAPK) pathway to downregulate POP-1.
Other_nameWnt signalling pathway
Related_topicSpecialisation_ofWBbiopr:00000020
WBbiopr:00000024
WBbiopr:00000094
WBbiopr:00000112
WBbiopr:00000107
WBbiopr:00000110
WBbiopr:00000114
Involved_entityGene (46)
InteractionWBInteraction000000920
WBInteraction000002710
WBInteraction000002711
WBInteraction000002712
WBInteraction000002713
WBInteraction000002714
WBInteraction000002715
WBInteraction000002716
WBInteraction000500225
WBInteraction000521868
WBInteraction000521869
WBInteraction000521870
WBInteraction000521871
WBInteraction000521872
WBInteraction000521873
WBInteraction000521874
WBInteraction000521875
WBInteraction000521876
WBInteraction000521992
WBInteraction000521993
WBInteraction000522279
WBInteraction000522280
WBInteraction000522281
WBInteraction000522282
WBInteraction000522289
WBInteraction000522290
WBInteraction000522292
WBInteraction000523922
WBInteraction000523923
WBInteraction000523924
WBInteraction000523925
WBInteraction000523926
WBInteraction000523927
WBInteraction000523928
WBInteraction000523929
WBInteraction000523930
WBInteraction000524019
WBInteraction000524210
WBInteraction000524211
WBInteraction000524212
WBInteraction000524213
WBInteraction000524214
WBInteraction000524215
WBInteraction000524216
WBInteraction000524217
WBInteraction000524218
WBInteraction000524346
WBInteraction000524808
WBInteraction000524809
WBInteraction000524810
WBInteraction000524811
WBInteraction000524812
WBInteraction000524813
WBInteraction000524814
WBInteraction000524815
WBInteraction000524816
WBInteraction000524817
WBInteraction000524818
WBInteraction000524819
WBInteraction000525095
WBInteraction000525096
WBInteraction000525149
WBInteraction000540004
WBInteraction000540018
WBInteraction000540019
WBInteraction000556895
Anatomy_term (15)
Associated_withPhenotypeWBPhenotype:0000104Paper_evidenceWBPaper00027192
GO_termGO:0016055
GO:0060070
Picture (17)
Reference (302)