WormBase Tree Display for Gene: WBGene00000939
expand all nodes | collapse all nodes | view schema
WBGene00000939 | Evidence | Paper_evidence | WBPaper00004772 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | K12H4 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | dcr | ||||||
Allele (78) | |||||||
Legacy_information | Homozygous s2624 and s2795 each develope into sterile adults. | ||||||
Strain (13) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (61) | |||||||
Ortholog (58) | |||||||
Paralog | WBGene00001090 | Caenorhabditis elegans | From_analysis | TreeFam | |||
WBGene00008400 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Structured_description | Concise_description | dcr-1 encodes a bidentate ribonuclease that is homologous to E. coli RNAse III; DCR-1 is required both for RNA interference and for synthesis of small developmental RNAs; DCR-1 functions to process pre-miRNAs into their mature, 22-nt form; DCR-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to DCR-1 for endonucleolytic processing; DCR-1 is also required for fragmention of chromosomal DNA during apoptosis, and undergoes a CED-3 protease-mediated conversion from a ribonuclease to a deoxyribonuclease. | Paper_evidence | WBPaper00004424 | |||
WBPaper00004923 | |||||||
WBPaper00005368 | |||||||
WBPaper00036025 | |||||||
WBPaper00024573 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 03 Feb 2014 00:00:00 | ||||||
Automated_description | Enables deoxyribonuclease I activity and ribonuclease III activity. Involved in several processes, including nucleic acid metabolic process; olfactory learning; and positive regulation of primary miRNA processing. Acts upstream of or within defense response to Gram-positive bacterium. Located in cytosol and nucleus. Expressed in germ line; intestine; neurons; and somatic cell. Human ortholog(s) of this gene implicated in several diseases, including DICER1 syndrome; gastrointestinal system cancer (multiple); and multinodular goiter. Is an ortholog of human DICER1 (dicer 1, ribonuclease III). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||
DOID:4769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||
DOID:0050745 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||
DOID:0080615 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||
DOID:0050489 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||
DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||
DOID:0081063 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||
DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17098) | ||||
Molecular_info | Corresponding_CDS | K12H4.8 | |||||
Corresponding_CDS_history | K12H4.8:wp230 | ||||||
Corresponding_transcript | K12H4.8.1 | ||||||
Other_sequence (58) | |||||||
Associated_feature | WBsf651241 | ||||||
WBsf667129 | |||||||
WBsf227077 | |||||||
WBsf227078 | |||||||
Experimental_info | RNAi_result (65) | ||||||
Expr_pattern | Expr10581 | ||||||
Expr11565 | |||||||
Expr12215 | |||||||
Expr12472 | |||||||
Expr1022725 | |||||||
Expr1030586 | |||||||
Expr1154395 | |||||||
Expr2010807 | |||||||
Expr2029044 | |||||||
Drives_construct | WBCnstr00005999 | ||||||
WBCnstr00006000 | |||||||
WBCnstr00006001 | |||||||
WBCnstr00017007 | |||||||
WBCnstr00020414 | |||||||
WBCnstr00037186 | |||||||
Construct_product (13) | |||||||
Regulate_expr_cluster | WBPaper00027057:DCR-1_interacting_adult | ||||||
WBPaper00027057:DCR-1_interacting_embryo | |||||||
WBPaper00029437:dcr-1_downregulated | |||||||
WBPaper00029437:dcr-1_upregulated | |||||||
WBPaper00059490:dcr-1(m9375)_downregulated | |||||||
WBPaper00059490:dcr-1(m9375)_upregulated | |||||||
Antibody | WBAntibody00000418 | ||||||
WBAntibody00001054 | |||||||
WBAntibody00001326 | |||||||
WBAntibody00001327 | |||||||
WBAntibody00001490 | |||||||
WBAntibody00002257 | |||||||
WBAntibody00002600 | |||||||
Microarray_results (18) | |||||||
Expression_cluster (137) | |||||||
Interaction (219) | |||||||
WBProcess | WBbiopr:00000014 | ||||||
WBbiopr:00000039 | |||||||
WBbiopr:00000057 | |||||||
WBbiopr:00000073 | |||||||
WBbiopr:00000081 | |||||||
Map_info | Map | III | Position | -0.385999 | Error | 0.003601 | |
Hide_under | WBGene00002843 | ||||||
Positive | Inside_rearr | nDf20 | |||||
sDp3 | |||||||
sDp8 | |||||||
Positive_clone | K12H4 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
Negative | Outside_rearr | sDf128 | |||||
Mapping_data | Multi_point | 5311 | |||||
Pos_neg_data | 9651 | ||||||
9674 | |||||||
9694 | |||||||
9695 | |||||||
9715 | |||||||
Reference (124) | |||||||
Remark | The let-740 gene is the same gene as dcr-1 and they therefore have been merged following advice from the CGC. let-740 is now an other name for dcr-1 [krb 030508] | ||||||
Method | Gene |