WormBase Tree Display for Gene: WBGene00003777
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| WBGene00003777 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | nmy-2 | |||||||
| Sequence_name | F20G4.3 | ||||||||
| Molecular_name | F20G4.3 | ||||||||
| F20G4.3.1 | |||||||||
| CE27133 | |||||||||
| Other_name | CELE_F20G4.3 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | nmy-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nmy | ||||||||
| Allele (89) | |||||||||
| Strain | WBStrain00003254 | ||||||||
| WBStrain00024208 | |||||||||
| WBStrain00024233 | |||||||||
| WBStrain00035727 | |||||||||
| WBStrain00040458 | |||||||||
| WBStrain00040459 | |||||||||
| WBStrain00024223 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (37) | |||||||||
| Contained_in_operon | CEOP1432 | ||||||||
| Ortholog (45) | |||||||||
| Paralog (21) | |||||||||
| Structured_description | Concise_description | nmy-2 encodes a non-muscle myosin II; NMY-2 is required for polarized cytoplasmic flow, polarized distribution of the PAR proteins, cytokinesis, and for proper anterior-posterior polarity in early embryos; NMY-2 functions with PAR-5 in the onset of the establishment phase of polarization in the C. elegans zygote along the anterior-posterior axis, and nmy-2 is partially redundant with nmy-1 with respect to embryonic elongation; NMY-2 localization is dynamic in oocytes and embryos, with localization seen at the cell cortex, cleavage furrow, and spindle; once embryonic polarization is established, cortical NMY-2 localizes asymmetrically, with higher levels seen in the anterior cortex; NMY-2 binds bovine calmodulin in vitro in a calcium-dependent manner; during larval development, NMY-2 is required for correct fate specification in seam cell divisions. | Paper_evidence | WBPaper00002506 | |||||
| WBPaper00003624 | |||||||||
| WBPaper00005318 | |||||||||
| WBPaper00005735 | |||||||||
| WBPaper00006149 | |||||||||
| WBPaper00031011 | |||||||||
| WBPaper00036142 | |||||||||
| WBPaper00051366 | |||||||||
| Person_evidence | WBPerson24060 | ||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 21 Jul 2017 00:00:00 | ||||||||
| Automated_description | Enables calmodulin binding activity and protein kinase binding activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; cell division; and regulation of anatomical structure morphogenesis. Located in several cellular components, including cleavage furrow; contractile ring; and mitotic spindle. Expressed in several structures, including distal tip cell; germ line; hypodermal cell; neuroblasts; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including aortic aneurysm (multiple); auditory system disease (multiple); and blood platelet disease (multiple). Is an ortholog of human MYH10 (myosin heavy chain 10); MYH11 (myosin heavy chain 11); and MYH9 (myosin heavy chain 9). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (13) | ||||||||
| Molecular_info | Corresponding_CDS | F20G4.3 | |||||||
| Corresponding_CDS_history | F20G4.3:wp47 | ||||||||
| Corresponding_transcript | F20G4.3.1 | ||||||||
| Other_sequence (26) | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result (38) | ||||||||
| Expr_pattern (22) | |||||||||
| Drives_construct (11) | |||||||||
| Construct_product | WBCnstr00001385 | ||||||||
| WBCnstr00005206 | |||||||||
| WBCnstr00015078 | |||||||||
| WBCnstr00017843 | |||||||||
| WBCnstr00038045 | |||||||||
| WBCnstr00040019 | |||||||||
| Antibody | WBAntibody00000114 | ||||||||
| WBAntibody00000929 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (137) | |||||||||
| Interaction (212) | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| WBbiopr:00000073 | |||||||||
| Map_info | Map | I | Position | 2.4083 | Error | 0.002722 | |||
| Positive | Positive_clone | F20G4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4539 | |||||||
| 4893 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (148) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
