WormBase Tree Display for Gene: WBGene00003777

WBGene00003777 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: nmy-2
      Sequence_name: F20G4.3
      Molecular_name: F20G4.3
        F20G4.3.1
        CE27133
      Other_name: CELE_F20G4.3 Accession_evidence: NDB BX284601
      Public_name: nmy-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nmy
    Allele (89)
    Strain: WBStrain00003254
      WBStrain00024208
      WBStrain00024233
      WBStrain00035727
      WBStrain00040458
      WBStrain00040459
      WBStrain00024223
    RNASeq_FPKM (74)
    GO_annotation (37)
    Contained_in_operon: CEOP1432
    Ortholog (45)
    Paralog (21)
    Structured_description: Concise_description: nmy-2 encodes a non-muscle myosin II; NMY-2 is required for polarized cytoplasmic flow, polarized distribution of the PAR proteins, cytokinesis, and for proper anterior-posterior polarity in early embryos; NMY-2 functions with PAR-5 in the onset of the establishment phase of polarization in the C. elegans zygote along the anterior-posterior axis, and nmy-2 is partially redundant with nmy-1 with respect to embryonic elongation; NMY-2 localization is dynamic in oocytes and embryos, with localization seen at the cell cortex, cleavage furrow, and spindle; once embryonic polarization is established, cortical NMY-2 localizes asymmetrically, with higher levels seen in the anterior cortex; NMY-2 binds bovine calmodulin in vitro in a calcium-dependent manner; during larval development, NMY-2 is required for correct fate specification in seam cell divisions. Paper_evidence: WBPaper00002506
            WBPaper00003624
            WBPaper00005318
            WBPaper00005735
            WBPaper00006149
            WBPaper00031011
            WBPaper00036142
            WBPaper00051366
          Person_evidence: WBPerson24060
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 21 Jul 2017 00:00:00
      Automated_description: Enables calmodulin binding activity and protein kinase binding activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; cell division; and regulation of anatomical structure morphogenesis. Located in several cellular components, including cleavage furrow; contractile ring; and mitotic spindle. Expressed in several structures, including distal tip cell; germ line; hypodermal cell; neuroblasts; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including aortic aneurysm (multiple); auditory system disease (multiple); and blood platelet disease (multiple). Is an ortholog of human MYH10 (myosin heavy chain 10); MYH11 (myosin heavy chain 11); and MYH9 (myosin heavy chain 9). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (13)
  Molecular_info: Corresponding_CDS: F20G4.3
    Corresponding_CDS_history: F20G4.3:wp47
    Corresponding_transcript: F20G4.3.1
    Other_sequence (26)
    Associated_feature (15)
  Experimental_info: RNAi_result (38)
    Expr_pattern (22)
    Drives_construct (11)
    Construct_product: WBCnstr00001385
      WBCnstr00005206
      WBCnstr00015078
      WBCnstr00017843
      WBCnstr00038045
      WBCnstr00040019
    Antibody: WBAntibody00000114
      WBAntibody00000929
    Microarray_results (22)
    Expression_cluster (137)
    Interaction: WBInteraction000002223
      WBInteraction000009354
      WBInteraction000009462
      WBInteraction000009519
      WBInteraction000009620
      WBInteraction000009854
      WBInteraction000009861
      WBInteraction000028379
      WBInteraction000028514
      WBInteraction000028550
      WBInteraction000028807
      WBInteraction000028867
      WBInteraction000029341
      WBInteraction000031445
      WBInteraction000032576
      WBInteraction000032629
      WBInteraction000032741
      WBInteraction000032750
      WBInteraction000032835
      WBInteraction000032911
      WBInteraction000032967
      WBInteraction000033009
      WBInteraction000033103
      WBInteraction000033114
      WBInteraction000033203
      WBInteraction000033464
      WBInteraction000033800
      WBInteraction000034015
      WBInteraction000034150
      WBInteraction000034361
      WBInteraction000034413
      WBInteraction000034421
      WBInteraction000034422
      WBInteraction000034726
      WBInteraction000034755
      WBInteraction000035123
      WBInteraction000035237
      WBInteraction000035360
      WBInteraction000035981
      WBInteraction000036061
      WBInteraction000036075
      WBInteraction000036382
      WBInteraction000036458
      WBInteraction000036521
      WBInteraction000036560
      WBInteraction000036659
      WBInteraction000037208
      WBInteraction000037672
      WBInteraction000038003
      WBInteraction000038496
      WBInteraction000038757
      WBInteraction000039229
      WBInteraction000039611
      WBInteraction000039697
      WBInteraction000039899
      WBInteraction000040002
      WBInteraction000040578
      WBInteraction000040644
      WBInteraction000040937
      WBInteraction000041432
      WBInteraction000041519
      WBInteraction000042055
      WBInteraction000042525
      WBInteraction000042580
      WBInteraction000043047
      WBInteraction000043083
      WBInteraction000043102
      WBInteraction000043127
      WBInteraction000043192
      WBInteraction000043200
      WBInteraction000043209
      WBInteraction000043473
      WBInteraction000043488
      WBInteraction000044361
      WBInteraction000044917
      WBInteraction000045158
      WBInteraction000045249
      WBInteraction000045339
      WBInteraction000045690
      WBInteraction000045774
      WBInteraction000045981
      WBInteraction000046009
      WBInteraction000046381
      WBInteraction000046517
      WBInteraction000046928
      WBInteraction000046954
      WBInteraction000046975
      WBInteraction000046976
      WBInteraction000047392
      WBInteraction000047393
      WBInteraction000047394
      WBInteraction000047542
      WBInteraction000047910
      WBInteraction000047963
      WBInteraction000048395
      WBInteraction000048579
      WBInteraction000048587
      WBInteraction000048595
      WBInteraction000048652
      WBInteraction000049336
      WBInteraction000049578
      WBInteraction000049846
      WBInteraction000049895
      WBInteraction000049900
      WBInteraction000049999
      WBInteraction000050447
      WBInteraction000050468
      WBInteraction000110210
      WBInteraction000110211
      WBInteraction000110212
      WBInteraction000110213
      WBInteraction000115004
      WBInteraction000120813
      WBInteraction000122287
      WBInteraction000126425
      WBInteraction000126915
      WBInteraction000127071
      WBInteraction000134412
      WBInteraction000135114
      WBInteraction000136615
      WBInteraction000140669
      WBInteraction000140932
      WBInteraction000141397
      WBInteraction000143371
      WBInteraction000165133
      WBInteraction000165139
      WBInteraction000165142
      WBInteraction000180402
      WBInteraction000180403
      WBInteraction000185718
      WBInteraction000185883
      WBInteraction000188479
      WBInteraction000214236
      WBInteraction000218515
      WBInteraction000230077
      WBInteraction000249040
      WBInteraction000262501
      WBInteraction000291229
      WBInteraction000298630
      WBInteraction000304679
      WBInteraction000306112
      WBInteraction000309858
      WBInteraction000314164
      WBInteraction000315720
      WBInteraction000316383
      WBInteraction000353212
      WBInteraction000353416
      WBInteraction000355283
      WBInteraction000358128
      WBInteraction000359531
      WBInteraction000360612
      WBInteraction000370495
      WBInteraction000381644
      WBInteraction000384265
      WBInteraction000389004
      WBInteraction000392066
      WBInteraction000403165
      WBInteraction000405163
      WBInteraction000426887
      WBInteraction000431888
      WBInteraction000434137
      WBInteraction000435149
      WBInteraction000460065
      WBInteraction000470200
      WBInteraction000472540
      WBInteraction000501466
      WBInteraction000501547
      WBInteraction000502671
      WBInteraction000502924
      WBInteraction000503018
      WBInteraction000503392
      WBInteraction000503507
      WBInteraction000504198
      WBInteraction000504235
      WBInteraction000504663
      WBInteraction000504682
      WBInteraction000511850
      WBInteraction000511851
      WBInteraction000511915
      WBInteraction000517734
      WBInteraction000517735
      WBInteraction000517736
      WBInteraction000518924
      WBInteraction000521843
      WBInteraction000521844
      WBInteraction000521846
      WBInteraction000521847
      WBInteraction000521849
      WBInteraction000521850
      WBInteraction000521863
      WBInteraction000539980
      WBInteraction000540512
      WBInteraction000541042
      WBInteraction000541427
      WBInteraction000541555
      WBInteraction000541682
      WBInteraction000554134
      WBInteraction000554974
      WBInteraction000556247
      WBInteraction000556367
      WBInteraction000556470
      WBInteraction000557972
      WBInteraction000557973
      WBInteraction000557978
      WBInteraction000557979
      WBInteraction000558003
      WBInteraction000564098
      WBInteraction000567328
      WBInteraction000567409
      WBInteraction000573484
      WBInteraction000576791
      WBInteraction000578527
    WBProcess: WBbiopr:00000017
      WBbiopr:00000073
  Map_info: Map: I Position: 2.4083 Error: 0.002722
    Positive: Positive_clone: F20G4 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4539
        4893
    Pseudo_map_position
  Reference (148)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene