WormBase Tree Display for Gene: WBGene00003777

WBGene00003777 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: nmy-2
      Sequence_name: F20G4.3
      Molecular_name: F20G4.3
        F20G4.3.1
        CE27133
      Other_name: CELE_F20G4.3 Accession_evidence: NDB BX284601
      Public_name: nmy-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nmy
    Allele (89)
    Strain: WBStrain00003254
      WBStrain00024208
      WBStrain00024233
      WBStrain00035727
      WBStrain00040458
      WBStrain00040459
      WBStrain00024223
    RNASeq_FPKM (74)
    GO_annotation (37)
    Contained_in_operon: CEOP1432
    Ortholog (45)
    Paralog (21)
    Structured_description: Concise_description: nmy-2 encodes a non-muscle myosin II; NMY-2 is required for polarized cytoplasmic flow, polarized distribution of the PAR proteins, cytokinesis, and for proper anterior-posterior polarity in early embryos; NMY-2 functions with PAR-5 in the onset of the establishment phase of polarization in the C. elegans zygote along the anterior-posterior axis, and nmy-2 is partially redundant with nmy-1 with respect to embryonic elongation; NMY-2 localization is dynamic in oocytes and embryos, with localization seen at the cell cortex, cleavage furrow, and spindle; once embryonic polarization is established, cortical NMY-2 localizes asymmetrically, with higher levels seen in the anterior cortex; NMY-2 binds bovine calmodulin in vitro in a calcium-dependent manner; during larval development, NMY-2 is required for correct fate specification in seam cell divisions. Paper_evidence: WBPaper00002506
            WBPaper00003624
            WBPaper00005318
            WBPaper00005735
            WBPaper00006149
            WBPaper00031011
            WBPaper00036142
            WBPaper00051366
          Person_evidence: WBPerson24060
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 21 Jul 2017 00:00:00
      Automated_description: Enables calmodulin binding activity and protein kinase binding activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; cell division; and regulation of anatomical structure morphogenesis. Located in several cellular components, including cleavage furrow; contractile ring; and mitotic spindle. Expressed in several structures, including distal tip cell; germ line; hypodermal cell; neuroblasts; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including aortic aneurysm (multiple); auditory system disease (multiple); and blood platelet disease (multiple). Is an ortholog of human MYH10 (myosin heavy chain 10); MYH11 (myosin heavy chain 11); and MYH9 (myosin heavy chain 9). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (13)
  Molecular_info: Corresponding_CDS: F20G4.3
    Corresponding_CDS_history: F20G4.3:wp47
    Corresponding_transcript: F20G4.3.1
    Other_sequence (26)
    Associated_feature (15)
  Experimental_info: RNAi_result (38)
    Expr_pattern (22)
    Drives_construct (11)
    Construct_product: WBCnstr00001385
      WBCnstr00005206
      WBCnstr00015078
      WBCnstr00017843
      WBCnstr00038045
      WBCnstr00040019
    Antibody: WBAntibody00000114
      WBAntibody00000929
    Microarray_results (22)
    Expression_cluster (137)
    Interaction (212)
    WBProcess: WBbiopr:00000017
      WBbiopr:00000073
  Map_info: Map: I Position: 2.4083 Error: 0.002722
    Positive: Positive_clone: F20G4 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4539
        4893
    Pseudo_map_position
  Reference: WBPaper00002506
    WBPaper00002952
    WBPaper00003167
    WBPaper00003624
    WBPaper00003758
    WBPaper00004115
    WBPaper00004151
    WBPaper00004230
    WBPaper00004402
    WBPaper00004455
    WBPaper00004519
    WBPaper00004549
    WBPaper00005183
    WBPaper00005299
    WBPaper00005318
    WBPaper00005581
    WBPaper00005653
    WBPaper00005830
    WBPaper00006149
    WBPaper00006199
    WBPaper00006422
    WBPaper00010891
    WBPaper00011157
    WBPaper00011403
    WBPaper00013493
    WBPaper00016879
    WBPaper00017390
    WBPaper00017728
    WBPaper00017940
    WBPaper00018369
    WBPaper00019610
    WBPaper00019719
    WBPaper00023636
    WBPaper00024378
    WBPaper00024873
    WBPaper00025163
    WBPaper00025229
    WBPaper00025258
    WBPaper00025940
    WBPaper00026098
    WBPaper00026180
    WBPaper00026405
    WBPaper00026421
    WBPaper00026732
    WBPaper00027230
    WBPaper00027235
    WBPaper00027244
    WBPaper00027251
    WBPaper00027253
    WBPaper00027476
    WBPaper00028395
    WBPaper00028408
    WBPaper00028423
    WBPaper00028449
    WBPaper00028736
    WBPaper00028984
    WBPaper00030750
    WBPaper00031011
    WBPaper00031032
    WBPaper00031353
    WBPaper00031424
    WBPaper00031555
    WBPaper00032018
    WBPaper00032951
    WBPaper00034662
    WBPaper00035085
    WBPaper00035228
    WBPaper00035433
    WBPaper00035488
    WBPaper00035559
    WBPaper00035593
    WBPaper00036802
    WBPaper00037146
    WBPaper00037607
    WBPaper00037620
    WBPaper00037740
    WBPaper00038098
    WBPaper00038232
    WBPaper00038491
    WBPaper00039452
    WBPaper00039852
    WBPaper00039986
    WBPaper00040157
    WBPaper00040657
    WBPaper00042325
    WBPaper00042795
    WBPaper00043589
    WBPaper00044445
    WBPaper00045253
    WBPaper00045425
    WBPaper00046208
    WBPaper00046615
    WBPaper00047336
    WBPaper00047418
    WBPaper00047419
    WBPaper00048156
    WBPaper00048213
    WBPaper00048286
    WBPaper00048493
    WBPaper00048609
    WBPaper00049309
    WBPaper00050415
    WBPaper00050431
    WBPaper00050540
    WBPaper00051087
    WBPaper00051366
    WBPaper00051368
    WBPaper00051821
    WBPaper00051975
    WBPaper00052153
    WBPaper00053261
    WBPaper00053666
    WBPaper00054817
    WBPaper00055090
    WBPaper00056095
    WBPaper00056589
    WBPaper00056801
    WBPaper00057125
    WBPaper00057696
    WBPaper00057749
    WBPaper00057885
    WBPaper00057936
    WBPaper00059536
    WBPaper00059755
    WBPaper00060347
    WBPaper00060679
    WBPaper00060787
    WBPaper00060897
    WBPaper00061125
    WBPaper00061553
    WBPaper00061584
    WBPaper00061728
    WBPaper00062045
    WBPaper00062939
    WBPaper00063252
    WBPaper00063945
    WBPaper00064401
    WBPaper00064561
    WBPaper00064601
    WBPaper00065093
    WBPaper00065184
    WBPaper00065559
    WBPaper00065624
    WBPaper00065950
    WBPaper00066020
    WBPaper00066021
    WBPaper00066080
    WBPaper00066087
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene