WormBase Tree Display for Gene: WBGene00003150
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| WBGene00003150 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mbk-2 | Person_evidence | WBPerson1138 | |||||
| Sequence_name | F49E11.1 | ||||||||
| Molecular_name (42) | |||||||||
| Other_name | CELE_F49E11.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | mbk-2 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mbk | ||||||||
| Allele (429) | |||||||||
| Strain (30) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (67) | |||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00001994 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00003149 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00016465 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WBGene00016464 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WBGene00006517 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00013727 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00185089 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | mbk-2 encodes one of two C. elegans members of the DYRK (dual-specificity Yak1-related kinase) family of proteins that includes S. cerevisiae Yak1 and the Drosophila minibrain and DYRK2 kinases; MBK-2 activity is required maternally for the oocyte-to-egg transition that occurs during the earliest stages of embryonic development; specifically, MBK-2 is required for: 1) posterior localization of the germ plasm components PIE-1, POS-1, and PGL-1, and 2) post-fertilization degradation of a subset of maternal proteins including the MEI-1 and MEI-2 meiosis-specific katanin subunits, the OMA-1 oocyte maturation factor, and residual PIE-1 that remains anteriorly localized after its normal posterior segregation; MBK-2 also primes the MEX-5 polarity protein for subsequent phosphorylation by the polo-like kinase PLK-1; genetic analyses suggest that, in regulating the segregation and degradation of maternal proteins, MBK-2 lies downstream of the initial embryonic polarity cues established by the PAR and MEX proteins; MBK-2 activity depends upon progression through the meiotic divisions and is positively regulated by CDK-1 and negatively regulated by EGG-3 and EGG-4/5; MBK-2 physically interacts with EGG-3 and EGG-4, suggesting that regulation by EGG-3 and EGG-4 is direct; MBK-2 is expressed uniformly in the cortex of oocytes and newly fertilized zygotes; in later stage zygotes, just prior to the second meiotic division, MBK-2 becomes localized to discrete cortical foci, and by the first mitosis it is found predominantly on centrosomes and chromosomes; MBK-2 is also associated with P granules in the germline blastomeres P2, P3, and P4. | Paper_evidence | WBPaper00006085 | |||||
| WBPaper00006352 | |||||||||
| WBPaper00026970 | |||||||||
| WBPaper00026975 | |||||||||
| WBPaper00027607 | |||||||||
| WBPaper00031434 | |||||||||
| WBPaper00035427 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 02 Mar 2011 00:00:00 | ||||||||
| Automated_description | Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in several processes, including P granule disassembly; asymmetric protein localization involved in cell fate determination; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cell cortex and intracellular non-membrane-bounded organelle. Expressed in several structures, including body wall musculature; embryonic cell; gonad; oocyte; and pharynx. Used to study Down syndrome. Is an ortholog of human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) and DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14250 | Homo sapiens | Paper_evidence | WBPaper00005756 | ||||
| Accession_evidence | OMIM | 190685 | |||||||
| 614104 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 05 Jun 2017 00:00:00 | ||||||||
| Disease_relevance | Human DYRK1A gene encodes a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family, which includes Drosophila minibrain, and is a conserved gene located in the Down Syndrome critical region (DSCR) of chromosome 21; Down syndrome is the most frequent chromosomal abnormality in human infants, where DYRK1A overexpression is observed, and is characterized by a set of facial and physical features, heart defects, abnormalities in the immune and endocrine systems, spatial memory defecits and difficulty in converting short-term to long-term memories; in elegans, the genes mbk-1 and mbk-2 have close homology with human DYRK1A and hpk-1 is more distantly related; while mutants deficient for mbk-1 seem to be normal, overexpression of mbk-1 causes behavioral defects in chemotaxis, acting in mature, fully differentiated neurons; however, this defect could be reversed by bringing back normal mbk-1 levels, which provided the first hint that DYRK1-induced defects could be reversed; mbk-2(pk1427) homozygous animals display 100% penetrant maternal-effect embryonic lethality, making it difficult to test redundant function with mbk-1. | Homo sapiens | Paper_evidence | WBPaper00005756 | |||||
| Accession_evidence | OMIM | 600855 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 05 Jun 2017 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000129 | ||||||||
| Molecular_info | Corresponding_CDS (14) | ||||||||
| Corresponding_transcript (14) | |||||||||
| Other_sequence (53) | |||||||||
| Associated_feature (76) | |||||||||
| Experimental_info | RNAi_result (38) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00000360 | ||||||||
| WBCnstr00000362 | |||||||||
| WBCnstr00011276 | |||||||||
| WBCnstr00012087 | |||||||||
| Construct_product | WBCnstr00000083 | ||||||||
| WBCnstr00000084 | |||||||||
| WBCnstr00000088 | |||||||||
| WBCnstr00000362 | |||||||||
| WBCnstr00000364 | |||||||||
| WBCnstr00010903 | |||||||||
| WBCnstr00011276 | |||||||||
| WBCnstr00011667 | |||||||||
| WBCnstr00012087 | |||||||||
| Antibody | WBAntibody00001303 | ||||||||
| WBAntibody00001304 | |||||||||
| Microarray_results (61) | |||||||||
| Expression_cluster (155) | |||||||||
| Interaction (272) | |||||||||
| Map_info | Map | IV | Position | 6.86808 | Error | 0.065322 | |||
| Positive | Positive_clone | F49E11 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4484 | |||||||
| Pseudo_map_position | |||||||||
| Reference (64) | |||||||||
| Remark | Sequence connection from [Raich WB]. 02/06/12 krb. | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
