WormBase Tree Display for Gene: WBGene00003150

WBGene00003150 SMap: S_parent: Sequence: CHROMOSOME_IV
  Identity: Version: 1
    Name: CGC_name: mbk-2 Person_evidence: WBPerson1138
      Sequence_name: F49E11.1
      Molecular_name (42)
      Other_name: CELE_F49E11.1 Accession_evidence: NDB BX284604
      Public_name: mbk-2
    DB_info: Database (14)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mbk
    Allele (429)
    Strain (30)
    RNASeq_FPKM: WBls:0000002 (85)
      WBls:0000003 (11)
      WBls:0000004 (47)
      WBls:0000006 137.003 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000006.Hermaphrodite.WBbt:0007833.SRP042619.SRX559705
            RNASeq.elegans.WBStrain00000001.WBls:0000006.Hermaphrodite.WBbt:0007833.SRP042619.SRX559706
      WBls:0000007 (11)
      WBls:0000008 138.972 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000008.Hermaphrodite.WBbt:0007833.SRP000401.SRX145480
        324.217 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000008.Hermaphrodite.WBbt:0007833.SRP000401.SRX085220
        98.4392 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000008.Hermaphrodite.WBbt:0007833.SRP000401.SRX085219
      WBls:0000010 (15)
      WBls:0000013 (11)
      WBls:0000014 (19)
      WBls:0000015 (24)
      WBls:0000017 116.941 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0008115.SRP029448.SRX343342
        177.314 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004015.SRP029448.SRX343305
        177.621 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0003810.SRP029448.SRX343324
        181.671 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004015.SRP029448.SRX343304
        200.058 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004458.SRP029448.SRX343277
        29.7169 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0003810.SRP029448.SRX343325
        317.607 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004458.SRP029448.SRX343278
        33.8898 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004804.SRP029448.SRX343254
        53.7044 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004804.SRP029448.SRX343252
        90.1732 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004804.SRP029448.SRX343253
      WBls:0000020 (16)
      WBls:0000021 (20)
      WBls:0000023 0.692265 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000023.Hermaphrodite.WBbt:0007833.SRP015688.SRX185639
      WBls:0000024 (71)
      WBls:0000027 (15)
      WBls:0000031 115.008 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX008139
        121.531 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103275
        130.206 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103274
        139.08 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103273
        146.31 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103276
        70.1088 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX047470
        88.9464 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103277
      WBls:0000032 116.813 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP000401.SRX103985
        119.348 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP000401.SRX103983
        41.3456 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP058023.SRX1019178
        51.7154 From_analysis: RNASeq.elegans.WBls:0000032.control_mean
            RNASeq.elegans.WBls:0000032.control_median
        62.0852 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP058023.SRX1019179
        65.9057 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP000401.SRX103984
        90.4649 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP000401.SRX008138
      WBls:0000035 (31)
      WBls:0000038 (88)
      WBls:0000041 (31)
      WBls:0000052 110.667 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103271
        114.579 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103278
        118.075 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103281
        118.435 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103280
        120.231 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103272
        124.199 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103269
        125.545 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103270
        134.528 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103279
        28.2015 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX008140
        54.9253 From_analysis: RNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX037199
      WBls:0000063 (103)
      WBls:0000064 (14)
      WBls:0000065 (16)
      WBls:0000068 206.163 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265364
        206.455 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265361
        226.9 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265360
        242.759 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265363
        258.011 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265362
        278.299 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265365
      WBls:0000131 188.659 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006876.SRP029448.SRX343221
        203.792 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0004015.SRP029448.SRX343227
        212.663 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006771.SRP029448.SRX343225
        218.972 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006876.SRP029448.SRX343223
        227.042 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0004015.SRP029448.SRX343228
        239.555 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006771.SRP029448.SRX343226
        240.485 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006876.SRP029448.SRX343222
        265.916 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0004015.SRP029448.SRX343229
        280.3 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0004015.SRP029448.SRX343220
      WBls:0000141 139.226 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000141.Hermaphrodite.WBbt:0007833.SRP029448.SRX343161
      WBls:0000151 (14)
      WBls:0000171 (15)
      WBls:0000181 93.3664 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000181.Hermaphrodite.WBbt:0007833.SRP029448.SRX343164
      WBls:0000191 85.9861 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000191.Hermaphrodite.WBbt:0007833.SRP029448.SRX343165
      WBls:0000201 (12)
      WBls:0000221 166.321 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004458.SRP029448.SRX343265
        168.047 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004458.SRP029448.SRX343264
        191.083 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0008115.SRP029448.SRX343334
        197.629 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0008115.SRP029448.SRX343333
        25.9058 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004458.SRP029448.SRX343266
        56.3275 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004804.SRP029448.SRX343241
        67.4799 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0003810.SRP029448.SRX343315
        75.4148 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0003810.SRP029448.SRX343314
        77.0776 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004015.SRP029448.SRX343290
        82.0266 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004015.SRP029448.SRX343291
      WBls:0000231 83.6235 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000231.Hermaphrodite.WBbt:0007833.SRP029448.SRX343167
      WBls:0000251 10.7171 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0003810.SRP029448.SRX343317
        12.289 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004015.SRP029448.SRX343292
        139.736 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0008115.SRP029448.SRX343337
        171.094 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0008115.SRP029448.SRX343336
        36.9117 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004804.SRP029448.SRX343243
        37.266 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004804.SRP029448.SRX343244
        376.666 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0008115.SRP029448.SRX343335
        62.2228 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004804.SRP029448.SRX343242
        64.7361 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004458.SRP029448.SRX343268
        99.2749 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0007833.SRP029448.SRX343168
      WBls:0000261 96.2523 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000261.Hermaphrodite.WBbt:0007833.SRP029448.SRX343169
      WBls:0000281 115.213 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000281.Hermaphrodite.WBbt:0007833.SRP029448.SRX343170
      WBls:0000291 (13)
      WBls:0000301 97.1318 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000301.Hermaphrodite.WBbt:0007833.SRP029448.SRX343172
      WBls:0000311 137.399 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000311.Hermaphrodite.WBbt:0007833.SRP029448.SRX343173
      WBls:0000321 123.44 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000321.Hermaphrodite.WBbt:0007833.SRP029448.SRX343174
      WBls:0000331 209.946 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000331.Hermaphrodite.WBbt:0007833.SRP029448.SRX343176
        35.0895 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000331.Hermaphrodite.WBbt:0007833.SRP029448.SRX343175
      WBls:0000351 127.748 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000351.Hermaphrodite.WBbt:0007833.SRP029448.SRX343178
        170.642 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000351.Hermaphrodite.WBbt:0007833.SRP029448.SRX343179
      WBls:0000361 120.013 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000361.Hermaphrodite.WBbt:0007833.SRP029448.SRX343180
      WBls:0000381 116.551 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004015.SRP029448.SRX343299
        121.706 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004015.SRP029448.SRX343297
        128.008 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0008115.SRP029448.SRX343340
        129.583 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004458.SRP029448.SRX343275
        136.956 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004804.SRP029448.SRX343249
        219.118 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004458.SRP029448.SRX343274
        64.2148 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004804.SRP029448.SRX343248
        80.0962 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004804.SRP029448.SRX343250
        85.6589 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0003810.SRP029448.SRX343320
      WBls:0000391 175.064 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000391.Hermaphrodite.WBbt:0007833.SRP029448.SRX343181
      WBls:0000401 160.136 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000401.Hermaphrodite.WBbt:0007833.SRP029448.SRX343182
      WBls:0000421 176.06 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000421.Hermaphrodite.WBbt:0007833.SRP029448.SRX343184
      WBls:0000431 174.892 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000431.Hermaphrodite.WBbt:0007833.SRP029448.SRX343185
      WBls:0000451 179.337 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000451.Hermaphrodite.WBbt:0007833.SRP029448.SRX343186
      WBls:0000461 179.544 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000461.Hermaphrodite.WBbt:0007833.SRP029448.SRX343187
      WBls:0000471 138.891 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004015.SRP029448.SRX343302
        228.609 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004015.SRP029448.SRX343300
        238.027 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0007833.SRP029448.SRX343189
        293.808 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004015.SRP029448.SRX343301
        38.8316 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004804.SRP029448.SRX343251
        53.9867 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0008115.SRP029448.SRX343341
        91.4883 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004458.SRP029448.SRX343276
      WBls:0000491 179.995 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000491.Hermaphrodite.WBbt:0007833.SRP029448.SRX343191
      WBls:0000501 113.479 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000501.Hermaphrodite.WBbt:0007833.SRP029448.SRX343192
      WBls:0000511 234.33 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000511.Hermaphrodite.WBbt:0007833.SRP029448.SRX343194
      WBls:0000521 134.192 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000521.Hermaphrodite.WBbt:0007833.SRP029448.SRX343195
      WBls:0000531 128.964 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000531.Hermaphrodite.WBbt:0007833.SRP029448.SRX343197
        182.539 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000531.Hermaphrodite.WBbt:0007833.SRP029448.SRX343196
      WBls:0000541 111.05 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000541.Hermaphrodite.WBbt:0007833.SRP029448.SRX343198
        150.923 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000541.Hermaphrodite.WBbt:0007833.SRP029448.SRX343199
      WBls:0000551 130.613 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000551.Hermaphrodite.WBbt:0007833.SRP029448.SRX343200
      WBls:0000561 123.788 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000561.Hermaphrodite.WBbt:0007833.SRP029448.SRX343201
      WBls:0000581 159.722 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000581.Hermaphrodite.WBbt:0007833.SRP029448.SRX343202
      WBls:0000621 102.499 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000621.Hermaphrodite.WBbt:0007833.SRP029448.SRX343203
      WBls:0000674 199.041 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265369
        205.567 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265366
        206.538 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265370
        237.799 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265367
        239.856 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265371
        246.791 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265368
      WBls:0000676 221.709 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000676.Hermaphrodite.WBbt:0007833.SRP021083.SRX265372
        233.743 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000676.Hermaphrodite.WBbt:0007833.SRP021083.SRX265374
        241.125 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000676.Hermaphrodite.WBbt:0007833.SRP021083.SRX265375
        243.904 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000676.Hermaphrodite.WBbt:0007833.SRP021083.SRX265373
      WBls:0000694 93.6128 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000694.Hermaphrodite.WBbt:0007833.SRP029448.SRX343205
      WBls:0000695 71.0596 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000695.Hermaphrodite.WBbt:0007833.SRP029448.SRX343206
      WBls:0000696 61.3834 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000696.Hermaphrodite.WBbt:0007833.SRP029448.SRX343207
      WBls:0000697 79.5491 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000697.Hermaphrodite.WBbt:0007833.SRP029448.SRX343208
      WBls:0000699 42.0666 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000699.Hermaphrodite.WBbt:0007833.SRP029448.SRX343210
      WBls:0000700 28.955 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000700.Hermaphrodite.WBbt:0007833.SRP029448.SRX343211
      WBls:0000701 46.3665 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000701.Hermaphrodite.WBbt:0007833.SRP029448.SRX343212
      WBls:0000702 65.3974 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000702.Hermaphrodite.WBbt:0007833.SRP029448.SRX343213
      WBls:0000703 70.0671 From_analysis: RNASeq.elegans.WBStrain00000001.WBls:0000703.Hermaphrodite.WBbt:0007833.SRP029448.SRX343214
    GO_annotation (67)
    Ortholog (42)
    Paralog: WBGene00001994 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003149 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00016465 Caenorhabditis elegans From_analysis: TreeFam
            Panther
      WBGene00016464 Caenorhabditis elegans From_analysis: TreeFam
            Panther
      WBGene00006517 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013727 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00185089 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: mbk-2 encodes one of two C. elegans members of the DYRK (dual-specificity Yak1-related kinase) family of proteins that includes S. cerevisiae Yak1 and the Drosophila minibrain and DYRK2 kinases; MBK-2 activity is required maternally for the oocyte-to-egg transition that occurs during the earliest stages of embryonic development; specifically, MBK-2 is required for: 1) posterior localization of the germ plasm components PIE-1, POS-1, and PGL-1, and 2) post-fertilization degradation of a subset of maternal proteins including the MEI-1 and MEI-2 meiosis-specific katanin subunits, the OMA-1 oocyte maturation factor, and residual PIE-1 that remains anteriorly localized after its normal posterior segregation; MBK-2 also primes the MEX-5 polarity protein for subsequent phosphorylation by the polo-like kinase PLK-1; genetic analyses suggest that, in regulating the segregation and degradation of maternal proteins, MBK-2 lies downstream of the initial embryonic polarity cues established by the PAR and MEX proteins; MBK-2 activity depends upon progression through the meiotic divisions and is positively regulated by CDK-1 and negatively regulated by EGG-3 and EGG-4/5; MBK-2 physically interacts with EGG-3 and EGG-4, suggesting that regulation by EGG-3 and EGG-4 is direct; MBK-2 is expressed uniformly in the cortex of oocytes and newly fertilized zygotes; in later stage zygotes, just prior to the second meiotic division, MBK-2 becomes localized to discrete cortical foci, and by the first mitosis it is found predominantly on centrosomes and chromosomes; MBK-2 is also associated with P granules in the germline blastomeres P2, P3, and P4. Paper_evidence: WBPaper00006085
            WBPaper00006352
            WBPaper00026970
            WBPaper00026975
            WBPaper00027607
            WBPaper00031434
            WBPaper00035427
          Curator_confirmed: WBPerson1843
          Date_last_updated: 02 Mar 2011 00:00:00
      Automated_description: Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in several processes, including P granule disassembly; asymmetric protein localization involved in cell fate determination; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cell cortex and intracellular non-membrane-bounded organelle. Expressed in several structures, including body wall musculature; embryonic cell; gonad; oocyte; and pharynx. Used to study Down syndrome. Is an ortholog of human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) and DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:14250 Homo sapiens Paper_evidence: WBPaper00005756
          Accession_evidence: OMIM 190685
              614104
          Curator_confirmed: WBPerson324
          Date_last_updated: 05 Jun 2017 00:00:00
    Disease_relevance: Human DYRK1A gene encodes a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family, which includes Drosophila minibrain, and is a conserved gene located in the Down Syndrome critical region (DSCR) of chromosome 21; Down syndrome is the most frequent chromosomal abnormality in human infants, where DYRK1A overexpression is observed, and is characterized by a set of facial and physical features, heart defects, abnormalities in the immune and endocrine systems, spatial memory defecits and difficulty in converting short-term to long-term memories; in elegans, the genes mbk-1 and mbk-2 have close homology with human DYRK1A and hpk-1 is more distantly related; while mutants deficient for mbk-1 seem to be normal, overexpression of mbk-1 causes behavioral defects in chemotaxis, acting in mature, fully differentiated neurons; however, this defect could be reversed by bringing back normal mbk-1 levels, which provided the first hint that DYRK1-induced defects could be reversed; mbk-2(pk1427) homozygous animals display 100% penetrant maternal-effect embryonic lethality, making it difficult to test redundant function with mbk-1. Homo sapiens Paper_evidence: WBPaper00005756
          Accession_evidence: OMIM 600855
          Curator_confirmed: WBPerson324
          Date_last_updated: 05 Jun 2017 00:00:00
  Models_disease_asserted: WBDOannot00000129
  Molecular_info: Corresponding_CDS (14)
    Corresponding_transcript (14)
    Other_sequence (53)
    Associated_feature (76)
  Experimental_info: RNAi_result (38)
    Expr_pattern (13)
    Drives_construct: WBCnstr00000360
      WBCnstr00000362
      WBCnstr00011276
      WBCnstr00012087
    Construct_product: WBCnstr00000083
      WBCnstr00000084
      WBCnstr00000088
      WBCnstr00000362
      WBCnstr00000364
      WBCnstr00010903
      WBCnstr00011276
      WBCnstr00011667
      WBCnstr00012087
    Antibody: WBAntibody00001303
      WBAntibody00001304
    Microarray_results (61)
    Expression_cluster (155)
    Interaction (272)
  Map_info: Map: IV Position: 6.86808 Error: 0.065322
    Positive: Positive_clone: F49E11 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4484
    Pseudo_map_position
  Reference (64)
  Remark: Sequence connection from [Raich WB]. 02/06/12 krb.
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene