WormBase Tree Display for Gene: WBGene00004326
expand all nodes | collapse all nodes | view schema
| WBGene00004326 | SMap | S_parent | Sequence | T20G5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | rde-4 | Person_evidence | WBPerson419 | |||||
| Sequence_name | T20G5.11 | ||||||||
| Molecular_name | T20G5.11 | ||||||||
| T20G5.11.1 | |||||||||
| CE00630 | |||||||||
| Other_name | CELE_T20G5.11 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | rde-4 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rde | ||||||||
| Allele (23) | |||||||||
| Strain | WBStrain00000440 | ||||||||
| WBStrain00000442 | |||||||||
| WBStrain00000449 | |||||||||
| WBStrain00000453 | |||||||||
| WBStrain00040421 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Contained_in_operon | CEOP3660 | ||||||||
| Ortholog (30) | |||||||||
| Structured_description | Concise_description | rde-4 encodes a protein containing two dsRNA-binding motifs; during the initiation phase of RNA interference (RNAi), RDE-4 appears to function in recognition and subsequent cleavage of long-trigger dsRNA molecules into small, interfering RNAs (siRNAs); RDE-4 exists in solution as a homodimer and binds long dsRNA with high affinity in a sequence-non-specific manner; in addition to forming a complex with the RNaseIII-related enzyme DCR-1, RDE-4 also interacts in vivo with RDE-1 and DRH-1, a conserved DExH-box helicase. | Paper_evidence | WBPaper00003711 | |||||
| WBPaper00004920 | |||||||||
| WBPaper00005368 | |||||||||
| WBPaper00027216 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 08 Jun 2007 00:00:00 | ||||||||
| Automated_description | Enables double-stranded RNA binding activity; protein homodimerization activity; and single-stranded RNA binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing and siRNA processing. Part of ribonucleoprotein complex. Human ortholog(s) of this gene implicated in dystonia 16. Is an ortholog of human PRKRA (protein activator of interferon induced protein kinase EIF2AK2) and TARBP2 (TARBP2 subunit of RISC loading complex). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0090048 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9438) | ||||
| Molecular_info | Corresponding_CDS | T20G5.11 | |||||||
| Corresponding_transcript | T20G5.11.1 | ||||||||
| Other_sequence | AY071926 | ||||||||
| CBC01998_1 | |||||||||
| CRC06105_1 | |||||||||
| Tcir_isotig29538 | |||||||||
| CRC02143_1 | |||||||||
| Associated_feature | WBsf651450 | ||||||||
| WBsf667375 | |||||||||
| WBsf667376 | |||||||||
| WBsf667377 | |||||||||
| WBsf667378 | |||||||||
| WBsf667379 | |||||||||
| WBsf227427 | |||||||||
| WBsf227428 | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr1017301 | ||||||||
| Expr1032150 | |||||||||
| Expr1157213 | |||||||||
| Expr2015286 | |||||||||
| Expr2033520 | |||||||||
| Construct_product | WBCnstr00000305 | ||||||||
| WBCnstr00000306 | |||||||||
| WBCnstr00005984 | |||||||||
| WBCnstr00009366 | |||||||||
| WBCnstr00019013 | |||||||||
| WBCnstr00019019 | |||||||||
| WBCnstr00019020 | |||||||||
| WBCnstr00019021 | |||||||||
| WBCnstr00019237 | |||||||||
| Regulate_expr_cluster | WBPaper00029437:rde-4_downregulated | ||||||||
| WBPaper00029437:rde-4_upregulated | |||||||||
| WBPaper00032425:down_in_rde-4 | |||||||||
| WBPaper00032425:up_in_rde-4 | |||||||||
| Antibody | WBAntibody00000534 | ||||||||
| WBAntibody00001329 | |||||||||
| WBAntibody00001489 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (151) | |||||||||
| Interaction (50) | |||||||||
| Anatomy_function | WBbtf0463 | ||||||||
| WBbtf0465 | |||||||||
| WBProcess | WBbiopr:00000008 | ||||||||
| WBbiopr:00000039 | |||||||||
| WBbiopr:00000057 | |||||||||
| Map_info | Map | III | Position | 2.01991 | Error | 0.004142 | |||
| Positive | Positive_clone | T20G5 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4629 | |||||||
| Pseudo_map_position | |||||||||
| Reference (123) | |||||||||
| Remark | Sequence connection from [Tabara H, Siomi S, Mello CC], [krb 020711] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
