WormBase Tree Display for Gene: WBGene00003222
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| WBGene00003222 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y2H9A | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | mes-4 | Person_evidence | WBPerson632 | |||||
| Sequence_name | Y2H9A.1 | ||||||||
| Molecular_name | Y2H9A.1 | ||||||||
| Y2H9A.1.1 | |||||||||
| CE27781 | |||||||||
| Other_name | CELE_Y2H9A.1 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | mes-4 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mes | ||||||||
| Allele (85) | |||||||||
| Legacy_information | [C.elegansII] bn50 : grandchildless, progeny undergo normal embryogenesis but develop into agametic adults(only 10 germ cells made). Normal P granule staining. XO germ line much less affected.OA3: bn23, bn58, bn67 (all similar). [Capowski et al. 1991; SS] | ||||||||
| Strain | WBStrain00022581 | ||||||||
| WBStrain00034440 | |||||||||
| WBStrain00036937 | |||||||||
| WBStrain00029957 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (30) | |||||||||
| Ortholog (56) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | mes-4 encodes a SET domain-containing protein that also contains three plant homeodomain (PHD) fingers; MES-4 is required maternally for normal germline development, but in contrast to MES-2, -3, and -6, does not appear to be required for somatic anteroposterior patterning; in germline development, MES-4 activity is essential for regulating active chromatin states and for excluding the MES-2/MES-3/MES-6 chromatin repression complex from the autosomes; MES-4 is also required for germline silencing of repetitive transgene arrays; MES-4 localizes to autosomes, and is detectable in the distal, mitotic region of the germline, in meiotic germ cells during late pachytene, and in oocytes; MES-4 is detected in all somatic and germline nuclei of the early embryo, but by the 100-cell stage, its expression becomes restricted to the primordial germ cells, Z2 and Z3; exclusion of MES-4 from X chromosomes requires the activity of the MES-2, -3, -6 complex. | Paper_evidence | WBPaper00002979 | |||||
| WBPaper00005301 | |||||||||
| WBPaper00005923 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 30 Jul 2004 00:00:00 | ||||||||
| Automated_description | Enables histone H3K36 methyltransferase activity. Involved in germ-line sex determination and heterochromatin formation. Acts upstream of or within with a positive effect on dosage compensation by hypoactivation of X chromosome. Located in X chromosome; autosome; and nuclear chromosome. Part of chromatin. Expressed in Z2; Z3; and germ line. Human ortholog(s) of this gene implicated in several diseases, including Sotos syndrome 1; lung non-small cell carcinoma; and neuroblastoma. Is an ortholog of human NSD1 (nuclear receptor binding SET domain protein 1); NSD2 (nuclear receptor binding SET domain protein 2); and NSD3 (nuclear receptor binding SET domain protein 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0112103 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||
| DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12766) | ||||||
| DOID:10907 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||||
| DOID:14748 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||||
| DOID:769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||||
| DOID:8692 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12767) | ||||||
| DOID:9119 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||||
| Molecular_info | Corresponding_CDS | Y2H9A.1 | |||||||
| Corresponding_CDS_history | Y2H9A.1:wp51 | ||||||||
| Corresponding_transcript | Y2H9A.1.1 | ||||||||
| Other_sequence | AF233290 | ||||||||
| CBC09012_1 | |||||||||
| CBC03017_1 | |||||||||
| CRC01044_1 | |||||||||
| CR09817 | |||||||||
| CR07209 | |||||||||
| CRC02608_1 | |||||||||
| Associated_feature (11) | |||||||||
| Gene_product_binds (4418) | |||||||||
| Transcription_factor | WBTranscriptionFactor000137 | ||||||||
| Experimental_info | RNAi_result (41) | ||||||||
| Expr_pattern | Expr1905 | ||||||||
| Expr4222 | |||||||||
| Expr14367 | |||||||||
| Expr1027992 | |||||||||
| Expr1031522 | |||||||||
| Expr1159295 | |||||||||
| Expr1200052 | |||||||||
| Expr2013532 | |||||||||
| Expr2031766 | |||||||||
| Drives_construct | WBCnstr00036178 | ||||||||
| Construct_product | WBCnstr00036178 | ||||||||
| Regulate_expr_cluster | WBPaper00028483:Down_mes-4_vs_WT | ||||||||
| WBPaper00028483:Up_mes-4_vs_WT | |||||||||
| WBPaper00041688:mes-2_mes-4_downregulated | |||||||||
| WBPaper00041688:mes-2_mes-4_upregulated | |||||||||
| WBPaper00064315:mes-4(bn73)_downregulated_EGCs | |||||||||
| WBPaper00064315:mes-4(bn73)_downregulated_PGCs | |||||||||
| WBPaper00064315:mes-4(bn73)_upregulated_EGCs | |||||||||
| WBPaper00064315:mes-4(bn73)_upregulated_PGCs | |||||||||
| Antibody | WBAntibody00000524 | ||||||||
| WBAntibody00001161 | |||||||||
| WBAntibody00001162 | |||||||||
| WBAntibody00001462 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (153) | |||||||||
| Interaction (83) | |||||||||
| Map_info | Map | V | Position | 5.34414 | Error | 0.004146 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | Y2H9A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Y29H9A | |||||||||
| Mapping_data | 2_point | 6090 | |||||||
| 6091 | |||||||||
| 6092 | |||||||||
| 6093 | |||||||||
| 6094 | |||||||||
| 6095 | |||||||||
| 6096 | |||||||||
| 6097 | |||||||||
| 6098 | |||||||||
| Multi_point | 2157 | ||||||||
| 2158 | |||||||||
| 2159 | |||||||||
| 2160 | |||||||||
| 2161 | |||||||||
| 2162 | |||||||||
| 2163 | |||||||||
| 2164 | |||||||||
| 2165 | |||||||||
| 2166 | |||||||||
| Pos_neg_data | 6685 | ||||||||
| 6686 | |||||||||
| 6687 | |||||||||
| Landmark_gene | |||||||||
| Reference (120) | |||||||||
| Remark | Sequence connection from [Strome S] | ||||||||
| Method | Gene |
