WormBase Tree Display for Gene: WBGene00001166
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| WBGene00001166 | SMap | S_parent | Sequence | ZK328 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | eftu-2 | Person_evidence | WBPerson1787 | |||||
| WBPerson10190 | |||||||||
| Sequence_name | ZK328.2 | ||||||||
| Molecular_name | ZK328.2 | ||||||||
| ZK328.2.1 | |||||||||
| CE05066 | |||||||||
| Other_name | eft-1 | ||||||||
| CELE_ZK328.2 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | eftu-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 03 Aug 2010 09:44:39 | WBPerson2970 | Name_change | CGC_name | eftu-1 | ||||
| Other_name | eft-1 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | eftu | ||||||||
| Allele (37) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes 849 aa protein, C-term has 47-58% similarity to elongation factors; N-term has homologywith GTP-binding proteins; lacks diphtheria toxin target His (Tyr instead). [Ofolue and Candido 1992] | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (38) | |||||||||
| Paralog (17) | |||||||||
| Structured_description | Concise_description | eftu-2 encodes an elongation factor 2 (EF-2)-like protein; by homology, EFTU-2 is predicted to function as a GTPase required for the elongation step of protein synthesis; loss of eftu-2 activity via large-scale RNAi indicates that eftu-2 is an essential gene required for embryonic development, reproduction, and the overall health of the animal; eftu-2 mRNA is detectable at all stages of C. elegans development. | Paper_evidence | WBPaper00001530 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 15 Apr 2013 00:00:00 | ||||||||
| Automated_description | Predicted to enable GTPase activity and U5 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol. Predicted to be part of U2-type catalytic step 2 spliceosome and U4/U6 x U5 tri-snRNP complex. Human ortholog(s) of this gene implicated in several diseases, including esophageal atresia; hepatitis B; and mandibulofacial dysostosis, Guion-Almeida type. Is an ortholog of human EFTUD2 (elongation factor Tu GTP binding domain containing 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10485 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30858) | ||||
| DOID:10907 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30858) | ||||||
| DOID:0080196 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30858) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30858) | ||||||
| DOID:2043 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30858) | ||||||
| Molecular_info | Corresponding_CDS | ZK328.2 | |||||||
| Corresponding_transcript | ZK328.2.1 | ||||||||
| Other_sequence (63) | |||||||||
| Associated_feature | WBsf645239 | ||||||||
| WBsf659025 | |||||||||
| WBsf225041 | |||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern | Expr1503 | ||||||||
| Expr1027676 | |||||||||
| Expr1030743 | |||||||||
| Expr1162766 | |||||||||
| Expr2011195 | |||||||||
| Expr2029431 | |||||||||
| Drives_construct | WBCnstr00037983 | ||||||||
| Construct_product | WBCnstr00037983 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (149) | |||||||||
| Interaction (331) | |||||||||
| Map_info | Map | III | Position | -1.42731 | Error | 0.0001 | |||
| Positive | Positive_clone | ZK328 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | yk16e11.3 removed from sequence list sdm 11/00 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
