WormBase Tree Display for Gene: WBGene00001166

WBGene00001166 SMap: S_parent: Sequence: ZK328
  Identity: Version: 2
    Name: CGC_name: eftu-2 Person_evidence: WBPerson1787
            WBPerson10190
      Sequence_name: ZK328.2
      Molecular_name: ZK328.2
        ZK328.2.1
        CE05066
      Other_name: eft-1
        CELE_ZK328.2 Accession_evidence: NDB BX284603
      Public_name: eftu-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 03 Aug 2010 09:44:39 WBPerson2970 Name_change: CGC_name: eftu-1
                Other_name: eft-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: eftu
    Allele (37)
    Legacy_information: [C.elegansII] NMK. Encodes 849 aa protein, C-term has 47-58% similarity to elongation factors; N-term has homologywith GTP-binding proteins; lacks diphtheria toxin target His (Tyr instead). [Ofolue and Candido 1992]
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (38)
    Paralog (17)
    Structured_description: Concise_description: eftu-2 encodes an elongation factor 2 (EF-2)-like protein; by homology, EFTU-2 is predicted to function as a GTPase required for the elongation step of protein synthesis; loss of eftu-2 activity via large-scale RNAi indicates that eftu-2 is an essential gene required for embryonic development, reproduction, and the overall health of the animal; eftu-2 mRNA is detectable at all stages of C. elegans development. Paper_evidence: WBPaper00001530
          Curator_confirmed: WBPerson1843
          Date_last_updated: 15 Apr 2013 00:00:00
      Automated_description: Predicted to enable GTPase activity and U5 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol. Predicted to be part of U2-type catalytic step 2 spliceosome and U4/U6 x U5 tri-snRNP complex. Human ortholog(s) of this gene implicated in several diseases, including esophageal atresia; hepatitis B; and mandibulofacial dysostosis, Guion-Almeida type. Is an ortholog of human EFTUD2 (elongation factor Tu GTP binding domain containing 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10485 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:30858)
      DOID:10907 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:30858)
      DOID:0080196 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:30858)
      DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:30858)
      DOID:2043 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:30858)
  Molecular_info: Corresponding_CDS: ZK328.2
    Corresponding_transcript: ZK328.2.1
    Other_sequence (63)
    Associated_feature: WBsf645239
      WBsf659025
      WBsf225041
  Experimental_info: RNAi_result (17)
    Expr_pattern: Expr1503
      Expr1027676
      Expr1030743
      Expr1162766
      Expr2011195
      Expr2029431
    Drives_construct: WBCnstr00037983
    Construct_product: WBCnstr00037983
    Microarray_results (21)
    Expression_cluster: WBPaper00028451:Abundant_spermatogenesis_enriched
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032528:L3_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00042477:prp-8(RNAi)_upregulated_RNAseq
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045396:CACN-1_associated
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00046337:monosomal_N2_vs_daf-2_upregulated
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:nucleus_specific
      WBPaper00051555:atm-1(gk186)_regulated_protein
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056826:SGP_biased
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058691:CFP-1_interacting_protein
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00059334:SACY-1_interacting
      WBPaper00059598:HeatShock_upregulated
      WBPaper00059605:MUT-16_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00061340:Excretory_cell_parent
      WBPaper00061340:Neuroblast_ASJ_AUA
      WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3
      WBPaper00061340:Parent_of_tail_spike_and_hyp10
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:AFFX-r2-3487-3_s_at-tba-1
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062056:lin-36(n766)_upregulated
      WBPaper00062056:lin-36(we36)_upregulated
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064201:SNA-3_interacting
      WBPaper00064716:paraquat_upregulated
      WBPaper00064735:bet-1(uth41)_vs_N2_downregulated
      WBPaper00065149:lin-52(n771)_upregulated
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_6_2
      cgc4489_group_4
      WBPaper00005124:testosterone_10-9M_regulated
      WBPaper00025032:cluster_197
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00032948:FedUp
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_F
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00039866:ClassComp_daf-19_upregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(83_min)
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
      [cgc6390]:oogenesis-enriched
    Interaction (331)
  Map_info: Map: III Position: -1.42731 Error: 0.0001
    Positive: Positive_clone: ZK328 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (14)
  Remark: yk16e11.3 removed from sequence list sdm 11/00
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene