WormBase Tree Display for Gene: WBGene00000423
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| WBGene00000423 | SMap | S_parent | Sequence | T07C4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ced-9 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T07C4.8 | ||||||||
| Molecular_name | T07C4.8 | ||||||||
| T07C4.8.1 | |||||||||
| CE25104 | |||||||||
| Other_name | CELE_T07C4.8 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | ced-9 | ||||||||
| DB_info | Database | AceView | gene | 3L427 | |||||
| WormQTL | gene | WBGene00000423 | |||||||
| WormFlux | gene | WBGene00000423 | |||||||
| NDB | locus_tag | CELE_T07C4.8 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000423|UniProtKB=P41958 | |||||||
| family | PTHR11256 | ||||||||
| NCBI | gene | 3565776 | |||||||
| RefSeq | protein | NM_066883.7 | |||||||
| SwissProt | UniProtAcc | P41958 | |||||||
| UniProt_GCRP | UniProtAcc | P41958 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ced | ||||||||
| Allele (39) | |||||||||
| Legacy_information | [C.elegansII] n1950sd : gf allele, reduced cell deaths. Intragenic lf revertants increase cell death:n1950n2077 (partial sterility, Mel, very sick embryo), n1950n2161 (weaker lf, Mel, ectopic cell deaths in embryo), n1653ts (weak lf, viable). Cloned: 2.1 kb (cyt-1 + ced-9) and 1.3 kb transcripts, latter encodes 280 aa protein related to mammalian bcl-2 (23% identity).3' of cyt-1, immediately adjacent, shares regulation. [Hengartner et al. 1992; Hengartner and Horvitz 1994;MT] | ||||||||
| Strain | WBStrain00027213 | ||||||||
| WBStrain00027104 | |||||||||
| WBStrain00027154 | |||||||||
| WBStrain00027218 | |||||||||
| WBStrain00027287 | |||||||||
| WBStrain00027305 | |||||||||
| WBStrain00027306 | |||||||||
| WBStrain00027393 | |||||||||
| WBStrain00030628 | |||||||||
| WBStrain00024084 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (70) | |||||||||
| Contained_in_operon | CEOP3666 | ||||||||
| Ortholog (14) | |||||||||
| Structured_description | Concise_description | ced-9 encodes the sole C. elegans homolog of the mammalian cell-death inhibitor Bcl-2; during development, ced-9 activity is essential for preventing cells from undergoing programmed cell death; ced-9 also appears to have proapoptotic activity; CED-9 functions by binding and repressing the activity of CED-4, a protein similar to human APAF-1 and positive regulator of CED-3 caspase activity; CED-9 localizes to the mitochondrial outer membrane, although this localization is not essential for CED-9 to regulate apoptosis. | Paper_evidence | WBPaper00001952 | |||||
| WBPaper00002943 | |||||||||
| WBPaper00003928 | |||||||||
| WBPaper00030948 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 24 Aug 2009 00:00:00 | ||||||||
| Automated_description | Enables GTPase activator activity and protein sequestering activity. Involved in several processes, including positive regulation of brood size; positive regulation of reproductive process; and regulation of cellular component organization. Located in several cellular components, including mitochondrial outer membrane; neuronal cell body; and perinuclear region of cytoplasm. Expressed in several structures, including gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; B-cell lymphoma (multiple); colorectal adenocarcinoma; and transient cerebral ischemia. Is an ortholog of human BCL2L2 (BCL2 like 2) and BCL2L2-PABPN1 (BCL2L2-PABPN1 readthrough). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:995) | ||||
| DOID:0050745 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:995) | ||||||
| DOID:224 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:995) | ||||||
| DOID:2377 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:995) | ||||||
| DOID:0050861 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:995) | ||||||
| DOID:8584 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:995) | ||||||
| Molecular_info | Corresponding_CDS | T07C4.8 | |||||||
| Corresponding_transcript | T07C4.8.1 | ||||||||
| Other_sequence | Tcol_isotig14495 | ||||||||
| HBC04125_1 | |||||||||
| Acan_isotig04451 | |||||||||
| CR00831 | |||||||||
| CRC03405_1 | |||||||||
| EX009924.1 | |||||||||
| Acan_isotig04450 | |||||||||
| CBC01291_1 | |||||||||
| CJC01001_1 | |||||||||
| Associated_feature | WBsf027925 | Paper_evidence | WBPaper00028561 | ||||||
| WBsf645558 | |||||||||
| WBsf659495 | |||||||||
| WBsf225709 | |||||||||
| WBsf225710 | |||||||||
| Experimental_info | RNAi_result (26) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00007340 | ||||||||
| WBCnstr00007341 | |||||||||
| WBCnstr00007342 | |||||||||
| WBCnstr00011843 | |||||||||
| WBCnstr00037553 | |||||||||
| Construct_product (23) | |||||||||
| Antibody | WBAntibody00000641 | ||||||||
| WBAntibody00000865 | |||||||||
| WBAntibody00000984 | |||||||||
| WBAntibody00001471 | |||||||||
| WBAntibody00001552 | |||||||||
| WBAntibody00002281 | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (111) | |||||||||
| SAGE_tag | SAGE:acactcggaaaacaaat | Strand | Sense | ||||||
| Unambiguously_mapped | |||||||||
| SAGE:aagtcgtcccagctccg | Strand | Antisense | |||||||
| SAGE:acactcggaa | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| Interaction (203) | |||||||||
| WBProcess | WBbiopr:00000008 | ||||||||
| WBbiopr:00000013 | |||||||||
| WBbiopr:00000014 | |||||||||
| WBbiopr:00000065 | |||||||||
| Map_info | Map | III | Position | 2.3576 | Error | 0.008883 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf40 | |||||||
| Positive_clone | F46H1 | ||||||||
| T07C4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 5137 | |||||||
| Multi_point (11) | |||||||||
| Landmark_gene | |||||||||
| Reference (412) | |||||||||
| Picture | WBPicture0000013091 | ||||||||
| Method | Gene |
