WormBase Tree Display for Gene: WBGene00000103
expand all nodes | collapse all nodes | view schema
| WBGene00000103 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | akt-2 | Person_evidence | WBPerson1122 | |||||
| Sequence_name | F28H6.1 | ||||||||
| Molecular_name | F28H6.1a | ||||||||
| F28H6.1a.1 | |||||||||
| CE18646 | |||||||||
| F28H6.1b | |||||||||
| CE29298 | |||||||||
| F28H6.1b.1 | |||||||||
| Other_name | CELE_F28H6.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | akt-2 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | akt | ||||||||
| Allele (204) | |||||||||
| Legacy_information | [Paradis S] No mutants known. Encodes AKT kinase, related to akt-1. Overexpression does not suppress age-1. akt-2::GFP is widely expressed. Inhibition of akt-2 by RNAi has no obvious phenotype, inhibition of both akt-2 and akt-1 leads to dauer-constitutive phenotype. Predicted gene F28H6.1 | ||||||||
| Strain | WBStrain00023654 | ||||||||
| WBStrain00035581 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Ortholog (35) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | akt-2 encodes a homolog of the serine/threonine kinase Akt/PKB, AKT-2, that is required for progression through the dauer stage of development and for the negative regulation of adult lifespan; inactivation of akt-2 causes animals to arrest constitutively at the dauer stage, while having an increased life span; widely expressed, AKT-2 is activated by the phospholipid products of phosphoinositide 3-kinase AGE-1/PI3K and by PDK-1, a homolog of vertebrate 3-phosphoinositide-dependent kinase-1 (PDK-1) Normal akt-2 (and akt-1) activity is required for excess pdk-1 activity to suppress the dauer-arrest phenotype of age-1, indicating that the 3-phosphoinositide-dependent kinase-1 homolog PDK-1 transduces signals from AGE-1 to AKT-2 (and AKT-1); conversely, the akt-2 loss-of-function phenotype is suppressed by daf-16 null mutations, indicating that the Fork head transcription factor DAF-16 is downstream of AKT-2 (and AKT-1), and that AKT-1 and AKT-2 act primarily to antagonize DAF-16. | Paper_evidence | WBPaper00003173 | |||||
| WBPaper00003568 | |||||||||
| WBPaper00005614 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and protein serine/threonine kinase activity. Involved in determination of adult lifespan; insulin receptor signaling pathway; and regulation of synaptic assembly at neuromuscular junction. Expressed in several structures, including excretory canal; neurons; pharynx; rectum; and vulva. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); coronary artery disease (multiple); and glucose metabolism disease (multiple). Is an ortholog of human AKT1 (AKT serine/threonine kinase 1); AKT2 (AKT serine/threonine kinase 2); and AKT3 (AKT serine/threonine kinase 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (38) | ||||||||
| Molecular_info | Corresponding_CDS | F28H6.1a | |||||||
| F28H6.1b | |||||||||
| Corresponding_transcript | F28H6.1a.1 | ||||||||
| F28H6.1b.1 | |||||||||
| Other_sequence | AF072381 | ||||||||
| Associated_feature | WBsf1007837 | ||||||||
| WBsf1007838 | |||||||||
| WBsf1024363 | |||||||||
| WBsf236648 | |||||||||
| WBsf236649 | |||||||||
| WBsf236650 | |||||||||
| WBsf236651 | |||||||||
| WBsf236652 | |||||||||
| Experimental_info | RNAi_result (44) | ||||||||
| Expr_pattern | Expr1409 | ||||||||
| Expr4144 | |||||||||
| Expr11783 | |||||||||
| Expr14932 | |||||||||
| Expr1020215 | |||||||||
| Expr1030053 | |||||||||
| Expr1149774 | |||||||||
| Expr2009284 | |||||||||
| Expr2027521 | |||||||||
| Drives_construct | WBCnstr00010265 | ||||||||
| WBCnstr00015111 | |||||||||
| WBCnstr00021718 | |||||||||
| WBCnstr00037730 | |||||||||
| WBCnstr00041589 | |||||||||
| Construct_product | WBCnstr00010265 | ||||||||
| WBCnstr00015111 | |||||||||
| WBCnstr00037730 | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (189) | |||||||||
| Interaction (149) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000025 | |||||||||
| WBbiopr:00000039 | |||||||||
| WBbiopr:00000074 | |||||||||
| Map_info | Map | X | Position | 16.5504 | Error | 0.017286 | |||
| Positive | Positive_clone | F28H6 | Person_evidence | WBPerson1350 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| R03E1 | Person_evidence | WBPerson1350 | |||||||
| Mapping_data | Multi_point | 4152 | |||||||
| Pseudo_map_position | |||||||||
| Reference (113) | |||||||||
| Picture | WBPicture0000013078 | ||||||||
| Remark | Data extracted from Paradis & Ruvkun (1998) | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
