WormBase Tree Display for Gene: WBGene00000103

WBGene00000103 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: akt-2 Person_evidence: WBPerson1122
      Sequence_name: F28H6.1
      Molecular_name: F28H6.1a
        F28H6.1a.1
        CE18646
        F28H6.1b
        CE29298
        F28H6.1b.1
      Other_name: CELE_F28H6.1 Accession_evidence: NDB BX284606
      Public_name: akt-2
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: akt
    Allele: WBVar01499887
      WBVar01499519
      WBVar01499888
      WBVar01499710
      WBVar02034983
      WBVar02027624
      WBVar00250093
      WBVar00084608
      WBVar00084609
      WBVar00084610
      WBVar00084611
      WBVar00084612
      WBVar00084613
      WBVar00084614
      WBVar00101787
      WBVar00084615
      WBVar02005448
      WBVar00101788
      WBVar01897961
      WBVar01206362
      WBVar01206363
      WBVar00234174
      WBVar01206364
      WBVar01206365
      WBVar01981614
      WBVar01206366
      WBVar02088447
      WBVar01206367
      WBVar01206368
      WBVar01206369
      WBVar01206370
      WBVar01849600
      WBVar01206371
      WBVar01941924
      WBVar01206372
      WBVar01941925
      WBVar01206373
      WBVar01941926
      WBVar01941927
      WBVar01206374
      WBVar01941928
      WBVar01760143
      WBVar01206375
      WBVar01941929
      WBVar01206376
      WBVar01760144
      WBVar01552642
      WBVar01760145
      WBVar01206377
      WBVar01206378
      WBVar01552643
      WBVar01206379
      WBVar01552644
      WBVar01679392
      WBVar01552645
      WBVar01206380
      WBVar01830873
      WBVar01552646
      WBVar01206381
      WBVar01552647
      WBVar01206382
      WBVar01552648
      WBVar01206383
      WBVar01206384
      WBVar01206385
      WBVar00217965
      WBVar01206386
      WBVar00217966
      WBVar01206387
      WBVar00217967
      WBVar01206388
      WBVar01206389
      WBVar01946279
      WBVar00217968
      WBVar01206390
      WBVar00217969
      WBVar00217970
      WBVar01206391
      WBVar01206392
      WBVar00217972
      WBVar00217974
      WBVar00599210
      WBVar00599211
      WBVar00091688
      WBVar00599212
      WBVar00599213
      WBVar00599214
      WBVar00599215
      WBVar01787889
      WBVar00599216
      WBVar00599217
      WBVar00599218
      WBVar00599219
      WBVar00237346
      WBVar00599220
      WBVar00599221
      WBVar00599222
      WBVar00599223
      WBVar00599224
      WBVar00599225
      WBVar00599226
      WBVar00599227
      WBVar00599228
      WBVar00599229
      WBVar00599230
      WBVar00599231
      WBVar00599232
      WBVar00599233
      WBVar00599234
      WBVar00599235
      WBVar00599236
      WBVar00599237
      WBVar00599238
      WBVar00599239
      WBVar00599240
      WBVar00599241
      WBVar01654889
      WBVar00599242
      WBVar00599243
      WBVar00599244
      WBVar00599245
      WBVar00599246
      WBVar00599247
      WBVar00599248
      WBVar00599249
      WBVar00599250
      WBVar00599251
      WBVar00599252
      WBVar00599253
      WBVar00599254
      WBVar01704001
      WBVar00599255
      WBVar00599256
      WBVar01704002
      WBVar00599257
      WBVar01704003
      WBVar00599258
      WBVar00599259
      WBVar00599260
      WBVar00599261
      WBVar00599262
      WBVar00599263
      WBVar00599264
      WBVar00599265
      WBVar00599266
      WBVar00599267
      WBVar00599268
      WBVar00599269
      WBVar00249839
      WBVar00599270
      WBVar00599271
      WBVar00599272
      WBVar00599273
      WBVar00523567
      WBVar00599274
      WBVar00523568
      WBVar00599275
      WBVar00523569
      WBVar00599276
      WBVar00523570
      WBVar00599277
      WBVar00523571
      WBVar00599278
      WBVar00523572
      WBVar00599279
      WBVar00523573
      WBVar00599280
      WBVar00523574
      WBVar01544772
      WBVar00599281
      WBVar01544773
      WBVar00599282
      WBVar00523575
      WBVar01544774
      WBVar00599283
      WBVar00523576
      WBVar00523577
      WBVar00599284
      WBVar01544775
      WBVar00523578
      WBVar01544776
      WBVar00599285
      WBVar00599286
      WBVar00523579
      WBVar01544777
      WBVar00599287
      WBVar00523580
      WBVar00523581
      WBVar00599288
      WBVar00599289
      WBVar00523582
      WBVar00523583
      WBVar00599290
      WBVar00599291
      WBVar00523584
      WBVar00523585
      WBVar00599292
      WBVar00599293
      WBVar00523586
      WBVar00599294
      WBVar00523587
      WBVar00599295
      WBVar01498960
      WBVar01500067
    Legacy_information: [Paradis S] No mutants known. Encodes AKT kinase, related to akt-1. Overexpression does not suppress age-1. akt-2::GFP is widely expressed. Inhibition of akt-2 by RNAi has no obvious phenotype, inhibition of both akt-2 and akt-1 leads to dauer-constitutive phenotype. Predicted gene F28H6.1
    Strain: WBStrain00023654
      WBStrain00035581
    RNASeq_FPKM (74)
    GO_annotation (28)
    Ortholog (35)
    Paralog (14)
    Structured_description: Concise_description: akt-2 encodes a homolog of the serine/threonine kinase Akt/PKB, AKT-2, that is required for progression through the dauer stage of development and for the negative regulation of adult lifespan; inactivation of akt-2 causes animals to arrest constitutively at the dauer stage, while having an increased life span; widely expressed, AKT-2 is activated by the phospholipid products of phosphoinositide 3-kinase AGE-1/PI3K and by PDK-1, a homolog of vertebrate 3-phosphoinositide-dependent kinase-1 (PDK-1) Normal akt-2 (and akt-1) activity is required for excess pdk-1 activity to suppress the dauer-arrest phenotype of age-1, indicating that the 3-phosphoinositide-dependent kinase-1 homolog PDK-1 transduces signals from AGE-1 to AKT-2 (and AKT-1); conversely, the akt-2 loss-of-function phenotype is suppressed by daf-16 null mutations, indicating that the Fork head transcription factor DAF-16 is downstream of AKT-2 (and AKT-1), and that AKT-1 and AKT-2 act primarily to antagonize DAF-16. Paper_evidence: WBPaper00003173
            WBPaper00003568
            WBPaper00005614
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and protein serine/threonine kinase activity. Involved in determination of adult lifespan; insulin receptor signaling pathway; and regulation of synaptic assembly at neuromuscular junction. Expressed in several structures, including excretory canal; neurons; pharynx; rectum; and vulva. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); coronary artery disease (multiple); and glucose metabolism disease (multiple). Is an ortholog of human AKT1 (AKT serine/threonine kinase 1); AKT2 (AKT serine/threonine kinase 2); and AKT3 (AKT serine/threonine kinase 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (38)
  Molecular_info: Corresponding_CDS: F28H6.1a
      F28H6.1b
    Corresponding_transcript: F28H6.1a.1
      F28H6.1b.1
    Other_sequence: AF072381
    Associated_feature: WBsf1007837
      WBsf1007838
      WBsf1024363
      WBsf236648
      WBsf236649
      WBsf236650
      WBsf236651
      WBsf236652
  Experimental_info: RNAi_result (44)
    Expr_pattern: Expr1409
      Expr4144
      Expr11783
      Expr14932
      Expr1020215
      Expr1030053
      Expr1149774
      Expr2009284
      Expr2027521
    Drives_construct: WBCnstr00010265
      WBCnstr00015111
      WBCnstr00021718
      WBCnstr00037730
      WBCnstr00041589
    Construct_product: WBCnstr00010265
      WBCnstr00015111
      WBCnstr00037730
    Microarray_results (30)
    Expression_cluster (189)
    Interaction (149)
    WBProcess: WBbiopr:00000001
      WBbiopr:00000025
      WBbiopr:00000039
      WBbiopr:00000074
  Map_info: Map: X Position: 16.5504 Error: 0.017286
    Positive: Positive_clone: F28H6 Person_evidence: WBPerson1350
          Inferred_automatically: From sequence, transcript, pseudogene data
        R03E1 Person_evidence: WBPerson1350
    Mapping_data: Multi_point: 4152
    Pseudo_map_position
  Reference (113)
  Picture: WBPicture0000013078
  Remark: Data extracted from Paradis & Ruvkun (1998)
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene