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| WBPicture0000013078 | Description | Figure 2. The DAF-2/DAF-16 pathway. (A) In the presence of an agonist ligand, such as the insulin-like peptide DAF-28, the DAF-2 receptor is activated and in turn activates the phosphatidylinositol-3 OH kinase AGE-1 that catalyses the conversion of phosphatidylinositol bisphosphate (PIP2) into phosphatidylinositol trisphosphate (PIP3).On one hand, PIP3 binds to the complex AKT-1/AKT-2 and leads to the exposure of two phosphorylation sites. On the other hand, the kinase PDK-1 by binding to PiP3 is recruited to the membrane where it can phosphorylate and activate AKT-1. The kinase AKT in turn phosphorylates the transcription factor DAF-16 and thereby ensure its cytoplasmic retention. (B) In the presence of an antagonist ligand such as INS-1, (or in a daf-2 loss of function mutant), the pathway is not active, DAF-16 is not phosphorylated and can be translocated to the nucleus where it regulates the expression of a set of stress response and antimicrobial genes. | |||
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| Name | Fig2.jpg | ||||
| Depict | WBProcess | WBbiopr:00000039 | |||
| Gene | WBGene00002084 | ||||
| WBGene00000102 | |||||
| WBGene00000090 | |||||
| WBGene00000920 | |||||
| WBGene00000912 | |||||
| WBGene00000103 | |||||
| WBGene00003965 | |||||
| WBGene00000898 | |||||
| Acknowledgment | Template | From: <Journal_URL> <Article_URL>. Copyright <Publication_year>. | |||
| Publication_year | 2006 | ||||
| Article_URL | DOI | id | 10.1895/wormbook.1.83.1 | ||
| Journal_URL | WormBook | ||||
| Publisher_URL | Caltech | ||||
| Reference | WBPaper00027295 |
