WormBase Tree Display for Gene: WBGene00002084
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| WBGene00002084 | Evidence | Paper_evidence | WBPaper00003189 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| WBPaper00004623 | |||||||||
| SMap | S_parent | Sequence | F13B12 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | ins-1 | Person_evidence | WBPerson339 | |||||
| Sequence_name | F13B12.5 | ||||||||
| Molecular_name | F13B12.5 | ||||||||
| F13B12.5.1 | |||||||||
| CE27955 | |||||||||
| Other_name | ILP1 | Paper_evidence | WBPaper00003189 | ||||||
| Accession_evidence | EMBL | AF070472 | |||||||
| aho-2 | Paper_evidence | WBPaper00025146 | |||||||
| CELE_F13B12.5 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | ins-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 04 Dec 2006 15:17:24 | WBPerson1847 | Name_change | Other_name | aho-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ins | ||||||||
| Allele (18) | |||||||||
| Legacy_information | [Ferguson K] ins for INSulin related. No mutants known. | ||||||||
| Strain | WBStrain00022000 | ||||||||
| WBStrain00055157 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (25) | |||||||||
| Structured_description | Concise_description | ins-1 encodes an insulin-like peptide orthologous to human insulin (INS; OMIM:176730, mutated in hyperproinsulinemia and diabetes mellitus type II); INS-1 is one of 38 insulin-like peptides in C. elegans and when overexpressed can antagonize insulin-like signaling mediated by DAF-2/IR leading to arrest at the dauer larval stage; loss of INS-1, however, does not result in a dauer phenotype suggesting that INS-1 functions redundantly with other insulin-like peptides to regulate reproductive growth and lifespan; a mutation in ins-1 does, however, show severe defects in salt chemotaxis learning; INS-1 is expressed in the amphid sensory neurons ASI and ASJ that regulate dauer arrest, the nerve ring, the intestine, vulval muscles, and other neurons. | Paper_evidence | WBPaper00004623 | |||||
| WBPaper00028460 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 20 Mar 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable hormone activity. Involved in several processes, including learning or memory; negative regulation of insulin receptor signaling pathway; and regulation of dauer entry. Located in several cellular components, including cytoplasmic vesicle; neuron projection; and neuronal cell body. Expressed in several structures, including distal tip cell; egg-laying apparatus; head muscle; neurons; and somatic nervous system. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F13B12.5 | |||||||
| Corresponding_transcript | F13B12.5.1 | ||||||||
| Other_sequence | AF070472 | ||||||||
| OOC03647_1 | |||||||||
| Oden_isotig23058 | |||||||||
| NBC01607_1 | |||||||||
| Tcir_isotig13902 | |||||||||
| Acan_isotig15150 | |||||||||
| NB09753 | |||||||||
| Associated_feature | WBsf646302 | ||||||||
| WBsf660583 | |||||||||
| WBsf945410 | |||||||||
| WBsf997621 | |||||||||
| WBsf997622 | |||||||||
| WBsf1018090 | |||||||||
| WBsf228993 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00027789 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00107946 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00044478 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (16) | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product | WBCnstr00000451 | ||||||||
| WBCnstr00000452 | |||||||||
| WBCnstr00011877 | |||||||||
| WBCnstr00015031 | |||||||||
| WBCnstr00019276 | |||||||||
| WBCnstr00021721 | |||||||||
| WBCnstr00036467 | |||||||||
| WBCnstr00040133 | |||||||||
| WBCnstr00042670 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (147) | |||||||||
| Interaction (120) | |||||||||
| Map_info | Map | IV | Position | 4.59393 | Error | 0.001703 | |||
| Positive | Positive_clone | F13B12 | Author_evidence | Ferguson KC | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 5236 | |||||||
| 4373 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (70) | |||||||||
| Picture | WBPicture0000013078 | ||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
