WormBase Tree Display for Gene: WBGene00002084
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WBGene00002084 | Evidence | Paper_evidence | WBPaper00003189 | ||||
---|---|---|---|---|---|---|---|
WBPaper00004623 | |||||||
SMap | S_parent | Sequence | F13B12 | ||||
Identity | Version | 2 | |||||
Name | CGC_name | ins-1 | Person_evidence | WBPerson339 | |||
Sequence_name | F13B12.5 | ||||||
Molecular_name | F13B12.5 | ||||||
F13B12.5.1 | |||||||
CE27955 | |||||||
Other_name | ILP1 | Paper_evidence | WBPaper00003189 | ||||
Accession_evidence | EMBL | AF070472 | |||||
aho-2 | Paper_evidence | WBPaper00025146 | |||||
CELE_F13B12.5 | Accession_evidence | NDB | BX284604 | ||||
Public_name | ins-1 | ||||||
DB_info | Database (11) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ins | ||||||
Allele (18) | |||||||
Legacy_information | [Ferguson K] ins for INSulin related. No mutants known. | ||||||
Strain | WBStrain00022000 | ||||||
WBStrain00055157 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (15) | |||||||
Ortholog (25) | |||||||
Structured_description | Concise_description | ins-1 encodes an insulin-like peptide orthologous to human insulin (INS; OMIM:176730, mutated in hyperproinsulinemia and diabetes mellitus type II); INS-1 is one of 38 insulin-like peptides in C. elegans and when overexpressed can antagonize insulin-like signaling mediated by DAF-2/IR leading to arrest at the dauer larval stage; loss of INS-1, however, does not result in a dauer phenotype suggesting that INS-1 functions redundantly with other insulin-like peptides to regulate reproductive growth and lifespan; a mutation in ins-1 does, however, show severe defects in salt chemotaxis learning; INS-1 is expressed in the amphid sensory neurons ASI and ASJ that regulate dauer arrest, the nerve ring, the intestine, vulval muscles, and other neurons. | Paper_evidence | WBPaper00004623 | |||
WBPaper00028460 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 20 Mar 2008 00:00:00 | ||||||
Automated_description | Predicted to enable hormone activity. Involved in several processes, including learning or memory; negative regulation of insulin receptor signaling pathway; and regulation of dauer entry. Located in several cellular components, including cytoplasmic vesicle; neuron projection; and neuronal cell body. Expressed in several structures, including distal tip cell; egg-laying apparatus; head muscle; neurons; and somatic nervous system. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | F13B12.5 | |||||
Corresponding_transcript | F13B12.5.1 | ||||||
Other_sequence | AF070472 | ||||||
OOC03647_1 | |||||||
Oden_isotig23058 | |||||||
NBC01607_1 | |||||||
Tcir_isotig13902 | |||||||
Acan_isotig15150 | |||||||
NB09753 | |||||||
Associated_feature | WBsf646302 | ||||||
WBsf660583 | |||||||
WBsf945410 | |||||||
WBsf997621 | |||||||
WBsf997622 | |||||||
WBsf1018090 | |||||||
WBsf228993 | |||||||
Experimental_info | RNAi_result | WBRNAi00027789 | Inferred_automatically | RNAi_primary | |||
WBRNAi00107946 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00044478 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (16) | |||||||
Drives_construct (12) | |||||||
Construct_product | WBCnstr00000451 | ||||||
WBCnstr00000452 | |||||||
WBCnstr00011877 | |||||||
WBCnstr00015031 | |||||||
WBCnstr00019276 | |||||||
WBCnstr00021721 | |||||||
WBCnstr00036467 | |||||||
WBCnstr00040133 | |||||||
WBCnstr00042670 | |||||||
Microarray_results (20) | |||||||
Expression_cluster (147) | |||||||
Interaction (120) | |||||||
Map_info | Map | IV | Position | 4.59393 | Error | 0.001703 | |
Positive | Positive_clone | F13B12 | Author_evidence | Ferguson KC | |||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Mapping_data | Multi_point | 5236 | |||||
4373 | |||||||
Pseudo_map_position | |||||||
Reference (70) | |||||||
Picture | WBPicture0000013078 | ||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |