| WBGene00002084 | Evidence | Paper_evidence | WBPaper00003189 |
|---|
| | | WBPaper00004623 |
| SMap | S_parent | Sequence | F13B12 |
| Identity | Version | 2 |
| | Name | CGC_name | ins-1 | Person_evidence | WBPerson339 |
| | | Sequence_name | F13B12.5 |
| | | Molecular_name | F13B12.5 |
| | | | F13B12.5.1 |
| | | | CE27955 |
| | | Other_name | ILP1 | Paper_evidence | WBPaper00003189 |
| | | | | Accession_evidence | EMBL | AF070472 |
| | | | aho-2 | Paper_evidence | WBPaper00025146 |
| | | | CELE_F13B12.5 | Accession_evidence | NDB | BX284604 |
| | | Public_name | ins-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 04 Dec 2006 15:17:24 | WBPerson1847 | Name_change | Other_name | aho-2 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | ins |
| | Allele (18) |
| | Legacy_information | [Ferguson K] ins for INSulin related. No mutants known. |
| | Strain | WBStrain00022000 |
| | | WBStrain00055157 |
| | RNASeq_FPKM (74) |
| | GO_annotation (15) |
| | Ortholog (25) |
| | Structured_description | Concise_description | ins-1 encodes an insulin-like peptide orthologous to human insulin (INS; OMIM:176730, mutated in hyperproinsulinemia and diabetes mellitus type II); INS-1 is one of 38 insulin-like peptides in C. elegans and when overexpressed can antagonize insulin-like signaling mediated by DAF-2/IR leading to arrest at the dauer larval stage; loss of INS-1, however, does not result in a dauer phenotype suggesting that INS-1 functions redundantly with other insulin-like peptides to regulate reproductive growth and lifespan; a mutation in ins-1 does, however, show severe defects in salt chemotaxis learning; INS-1 is expressed in the amphid sensory neurons ASI and ASJ that regulate dauer arrest, the nerve ring, the intestine, vulval muscles, and other neurons. | Paper_evidence | WBPaper00004623 |
| | | | | | WBPaper00028460 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 20 Mar 2008 00:00:00 |
| | | Automated_description | Predicted to enable hormone activity. Involved in several processes, including learning or memory; negative regulation of insulin receptor signaling pathway; and regulation of dauer entry. Located in several cellular components, including cytoplasmic vesicle; neuron projection; and neuronal cell body. Expressed in several structures, including distal tip cell; egg-laying apparatus; head muscle; neurons; and somatic nervous system. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F13B12.5 |
| | Corresponding_transcript | F13B12.5.1 |
| | Other_sequence | AF070472 |
| | | OOC03647_1 |
| | | Oden_isotig23058 |
| | | NBC01607_1 |
| | | Tcir_isotig13902 |
| | | Acan_isotig15150 |
| | | NB09753 |
| | Associated_feature | WBsf646302 |
| | | WBsf660583 |
| | | WBsf945410 |
| | | WBsf997621 |
| | | WBsf997622 |
| | | WBsf1018090 |
| | | WBsf228993 |
| Experimental_info | RNAi_result | WBRNAi00027789 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00107946 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00044478 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (16) |
| | Drives_construct (12) |
| | Construct_product | WBCnstr00000451 |
| | | WBCnstr00000452 |
| | | WBCnstr00011877 |
| | | WBCnstr00015031 |
| | | WBCnstr00019276 |
| | | WBCnstr00021721 |
| | | WBCnstr00036467 |
| | | WBCnstr00040133 |
| | | WBCnstr00042670 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00037950:A-class-motor-neurons_CoreEnriched |
| | | WBPaper00037950:A-class-motor-neurons_embryo_enriched |
| | | WBPaper00037950:A-class-motor-neurons_embryo_SelectivelyEnriched |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:A-class-motor-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:BAG-neuron_embryo_enriched |
| | | WBPaper00037950:BAG-neuron_embryo_SelectivelyEnriched |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_tiling |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031) |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055648:male-tail_expressed |
| | | WBPaper00055648:nerve-ring_expressed |
| | | WBPaper00055971:nhl-2(ok818)_20C_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056284:ints-1(RNAi)_downregulated |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00057068:numr-1(RNAi)_downregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059117:B.subtilis_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060634:fhod-1(tm2363)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AIA |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:AIN |
| | | WBPaper00061340:ASG |
| | | WBPaper00061340:BAG |
| | | WBPaper00061340:I5 |
| | | WBPaper00061340:RIH |
| | | WBPaper00061340:URX |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061527:syd-1_2945-unc-41_2170 |
| | | WBPaper00061651:AIA_enriched |
| | | WBPaper00061651:AIM_enriched |
| | | WBPaper00061651:AIN_enriched |
| | | WBPaper00061651:AIZ_enriched |
| | | WBPaper00061651:ASJ_enriched |
| | | WBPaper00061651:I5_enriched |
| | | WBPaper00061651:IL2_LR_enriched |
| | | WBPaper00061651:PVW_enriched |
| | | WBPaper00061651:RID_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064156:lipl-4(overexpress)_upregulated |
| | | WBPaper00064505:tamoxifen_downregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065623:89 |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065841:25_1 |
| | | WBPaper00065841:35_4 |
| | | WBPaper00065841:73_0 |
| | | WBPaper00065841:75_0 |
| | | WBPaper00065841:77_0 |
| | | WBPaper00065841:83_0 |
| | | WBPaper00065841:85_0 |
| | | WBPaper00065841:87_0 |
| | | WBPaper00065841:91_0 |
| | | WBPaper00065841:92_0 |
| | | WBPaper00065841:99_0 |
| | | WBPaper00065841:104_0 |
| | | WBPaper00065841:105_0 |
| | | WBPaper00065841:112_0 |
| | | WBPaper00065841:114_0 |
| | | WBPaper00065841:123_0 |
| | | WBPaper00065841:129_0 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Enterococcus_faecalis_upregulated |
| | | WBPaper00030985:Serratia_marcesens_downregulated |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00036286:Pattern_I |
| | | WBPaper00038172:tax-6null_up_regulated |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00045960:L1-L4-lethargus_upregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction (120) |
| Map_info | Map | IV | Position | 4.59393 | Error | 0.001703 |
| | Positive | Positive_clone | F13B12 | Author_evidence | Ferguson KC |
| | | | | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 5236 |
| | | | 4373 |
| | Pseudo_map_position |
| Reference (70) |
| Picture | WBPicture0000013078 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
