WormBase Tree Display for Gene: WBGene00003965
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| WBGene00003965 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pdk-1 | Person_evidence | WBPerson545 | |||||
| Sequence_name | H42K12.1 | ||||||||
| Molecular_name | H42K12.1a | ||||||||
| H42K12.1a.1 | |||||||||
| CE28739 | |||||||||
| H42K12.1b | |||||||||
| CE28740 | |||||||||
| H42K12.1b.1 | |||||||||
| Other_name | CELE_H42K12.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | pdk-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pdk | ||||||||
| Allele (100) | |||||||||
| Strain | WBStrain00022810 | ||||||||
| WBStrain00022839 | |||||||||
| WBStrain00022841 | |||||||||
| WBStrain00030725 | |||||||||
| WBStrain00030727 | |||||||||
| WBStrain00030733 | |||||||||
| WBStrain00005337 | |||||||||
| WBStrain00007900 | |||||||||
| WBStrain00007902 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (32) | |||||||||
| Ortholog (38) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | pdk-1 encodes the C. elegans 3-phosphoinositide-dependent kinase 1 ortholog; PDK-1 is a component of the DAF-2/insulin receptor-like signaling pathway and accordingly, functions to regulate such processes as dauer larvae formation, longevity, and salt chemotaxis learning; genetic analyses indicate that, in regulating dauer arrest, PDK-1 acts downstream of AGE-1/PI3K and upstream of the AKT-1 and AKT-2 kinases; a PDK-1::GFP fusion protein is expressed broadly beginning in late stage embryos and continuing on through adulthood; expression is seen in head, tail, and ventral cord motor neurons, pharyngeal tissues, hypodermal cells, the intestine, and the somatic gonad; in neurons, the PDK-1::GFP localizes to cell bodies and processes, with occasional expression seen in some neuronal nuclei. | Paper_evidence | WBPaper00003568 | |||||
| WBPaper00004720 | |||||||||
| WBPaper00028460 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 13 Dec 2006 00:00:00 | ||||||||
| Automated_description | Enables protein kinase activity. Involved in several processes, including cellular response to reactive oxygen species; dauer larval development; and regulation of synaptic assembly at neuromuscular junction. Located in axon; neuronal cell body; and nucleus. Expressed in several structures, including gonad; intestine; neurons; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and prostate cancer. Is an ortholog of human PDPK1 (3-phosphoinositide dependent protein kinase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8816) | ||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8816) | ||||||
| Molecular_info | Corresponding_CDS | H42K12.1a | |||||||
| H42K12.1b | |||||||||
| Corresponding_transcript | H42K12.1a.1 | ||||||||
| H42K12.1b.1 | |||||||||
| Other_sequence (34) | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00109305 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00109499 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00109402 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00049558 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00016353 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00109208 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00109596 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092508 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1331 | ||||||||
| Expr13065 | |||||||||
| Expr1013319 | |||||||||
| Expr1031889 | |||||||||
| Expr1153286 | |||||||||
| Expr2014809 | |||||||||
| Expr2033043 | |||||||||
| Drives_construct (11) | |||||||||
| Construct_product | WBCnstr00010224 | ||||||||
| WBCnstr00015104 | |||||||||
| WBCnstr00015105 | |||||||||
| WBCnstr00015106 | |||||||||
| WBCnstr00015107 | |||||||||
| WBCnstr00015108 | |||||||||
| WBCnstr00019297 | |||||||||
| WBCnstr00021715 | |||||||||
| WBCnstr00021716 | |||||||||
| WBCnstr00035768 | |||||||||
| Microarray_results (36) | |||||||||
| Expression_cluster (167) | |||||||||
| Interaction (97) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000025 | |||||||||
| WBbiopr:00000039 | |||||||||
| WBbiopr:00000074 | |||||||||
| Map_info | Map | X | Position | -18.3899 | Error | 0.051074 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | H42K12 | Author_evidence | Ailion EMM | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 3853 | |||||||
| 3870 | |||||||||
| 3871 | |||||||||
| 3872 | |||||||||
| 5069 | |||||||||
| Reference (114) | |||||||||
| Picture | WBPicture0000013078 | ||||||||
| Remark | H3301.a = predicted_gene. H42K12.1 is at correct end of cosmid to be same thing and has homol to kinases. sdm 12/99 | ||||||||
| H42K12.2 may not be the same gene. sdm 12/99 | |||||||||
| Method | Gene |
