WormBase Tree Display for Gene: WBGene00001983
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| WBGene00001983 | Evidence | Person_evidence | WBPerson367 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | E04A4 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | hoe-1 | Person_evidence | WBPerson367 | |||||
| Sequence_name | E04A4.4 | ||||||||
| Molecular_name | E04A4.4a | ||||||||
| E04A4.4a.1 | |||||||||
| CE29748 | |||||||||
| E04A4.4b | |||||||||
| CE36588 | |||||||||
| E04A4.4c | |||||||||
| CE48594 | |||||||||
| E04A4.4b.1 | |||||||||
| E04A4.4c.1 | |||||||||
| Other_name | CELE_E04A4.4 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | hoe-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hoe | ||||||||
| Allele (51) | |||||||||
| Strain | WBStrain00049335 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Contained_in_operon | CEOP4144 | ||||||||
| Ortholog (38) | |||||||||
| Structured_description | Concise_description | hoe-1 encodes, by alternative splicing, two isoforms of a putative metal-dependent hydrolase orthologous to human ELAC2; HOE-1 is required for fertility, normal growth progression during the late larval stages and germ line proliferation; since hoe-1(RNAi) animals do not produce gametes, hoe-1 may be required for mitosis and meiosis; hoe-1 deficiency suppresses the multivulva (Muv) phenotype of activated LET-60/RAS, while having no effect on other RAS pathway members. | Paper_evidence | WBPaper00005654 | |||||
| WBPaper00006401 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 29 Aug 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable 3'-tRNA processing endoribonuclease activity. Involved in nematode larval development; positive regulation of vulval development; and sexual reproduction. Predicted to be located in mitochondrion. Expressed in germ line. Used to study prostate cancer. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 17. Is an ortholog of human ELAC2 (elaC ribonuclease Z 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:10283 | Homo sapiens | Paper_evidence | WBPaper00006401 | ||||
| Accession_evidence | OMIM | 614731 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Oct 2013 00:00:00 | ||||||||
| Potential_model | DOID:0111496 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14198) | |||||
| Disease_relevance | The human ELAC2/HPC2 gene is a prostate cancer susceptibility gene and encodes a gene product containing a well-conserved histidine motif domain found in metal dependent hydrolases; ELAC2 has tRNA endonuclease activity and is highly expressed in the testis; in C. elegans, reduction of function of the orthologous hoe-1, results in slow-growing, sterile animals that cannot produce gametes; hoe-1 is required for germ cells to progress through mitosis and loss of hoe-1 results in severely under-proliferated germ lines, consistent with a role of regulating cell proliferation in humans; further hoe-1 knockdown suppresses let-60/Ras activating mutations in elegans. | Homo sapiens | Paper_evidence | WBPaper00006401 | |||||
| Accession_evidence | OMIM | 614731 | |||||||
| 605367 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 02 May 2014 00:00:00 | ||||||||
| Modifies_disease | DOID:10283 | ||||||||
| Models_disease_in_annotation | WBDOannot00000240 | ||||||||
| Modifies_disease_in_annotation | WBDOannot00000788 | ||||||||
| Molecular_info | Corresponding_CDS | E04A4.4a | |||||||
| E04A4.4b | |||||||||
| E04A4.4c | |||||||||
| Corresponding_transcript | E04A4.4a.1 | ||||||||
| E04A4.4b.1 | |||||||||
| E04A4.4c.1 | |||||||||
| Other_sequence (48) | |||||||||
| Associated_feature | WBsf667903 | ||||||||
| WBsf996385 | |||||||||
| WBsf230003 | |||||||||
| WBsf230004 | |||||||||
| Experimental_info | RNAi_result (32) | ||||||||
| Expr_pattern | Expr2875 | ||||||||
| Expr1026531 | |||||||||
| Expr1031152 | |||||||||
| Expr1147648 | |||||||||
| Expr2012534 | |||||||||
| Expr2030773 | |||||||||
| Drives_construct | WBCnstr00036542 | ||||||||
| Construct_product | WBCnstr00036542 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (147) | |||||||||
| Interaction (164) | |||||||||
| Map_info | Map | IV | Position | 0.747216 | Error | 0.009606 | |||
| Positive | Positive_clone | E04A4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00006401 | ||||||||
| WBPaper00035429 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00063922 | |||||||||
| WBPaper00063971 | |||||||||
| WBPaper00065026 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
