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WormBase Tree Display for Gene: WBGene00017699

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Name Class

WBGene00017699SMapS_parentSequenceF22D3
IdentityVersion2
NameCGC_nameflcn-1Person_evidenceWBPerson15935
Sequence_nameF22D3.2
Molecular_name (21)
Other_nameCELE_F22D3.2Accession_evidenceNDBBX284602
Public_nameflcn-1
DB_infoDatabaseAceViewgene2H237
WormQTLgeneWBGene00017699
WormFluxgeneWBGene00017699
OMIMdisease135150
gene607273
NDBlocus_tagCELE_F22D3.2
PanthergeneCAEEL|WormBase=WBGene00017699|UniProtKB=H2KY80
familyPTHR31441
NCBIgene174134
RefSeqproteinNM_001306549.4
NM_001330952.3
NM_001276732.2
NM_001381469.1
NM_001306551.3
NM_001381470.1
NM_001026937.5
TrEMBLUniProtAccS6FCY3
S6EZM3
K0M7B5
J7S130
S6F533
Q5DX40
S6FMZ4
UniProt_GCRPUniProtAccS6FMZ4
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:30:59WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
229 Jun 2012 17:03:10WBPerson2970Name_changeCGC_nameflcn-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classflcn
Allele (252)
StrainWBStrain00031743
RNASeq_FPKM (74)
GO_annotation (20)
Ortholog (40)
Structured_descriptionConcise_descriptionF22D3.2 encodes an ortholog of human folliculin (OMIM:607273, mutated inBirt-Hogg-Dube syndrome).Paper_evidenceWBPaper00028837
Curator_confirmedWBPerson567
Date_last_updated11 Dec 2006 00:00:00
Automated_descriptionPredicted to contribute to GTPase activator activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of TORC1 signaling; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol. Expressed in excretory cell; nervous system; spermatheca; and vulva. Used to study Birt-Hogg-Dube syndrome. Human ortholog(s) of this gene implicated in several diseases, including Birt-Hogg-Dube syndrome; primary spontaneous pneumothorax; and renal cell carcinoma. Is an ortholog of human FLCN (folliculin).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:0050676Homo sapiensPaper_evidenceWBPaper00048631
Accession_evidenceOMIM135150
Curator_confirmedWBPerson324
Date_last_updated03 Nov 2015 00:00:00
Potential_modelDOID:9256Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:27310)
DOID:0080218Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:27310)
DOID:4450Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:27310)
DOID:0050676Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:27310)
Models_disease_in_annotationWBDOannot00000382
Molecular_infoCorresponding_CDSF22D3.2c
F22D3.2d
F22D3.2e
F22D3.2f
F22D3.2g
F22D3.2i
F22D3.2j
Corresponding_CDS_historyF22D3.2:wp127
F22D3.2a:wp206
F22D3.2a:wp238
F22D3.2a:wp274
F22D3.2b:wp206
F22D3.2b:wp238
F22D3.2h:wp274
Corresponding_transcriptF22D3.2c.1
F22D3.2d.1
F22D3.2e.1
F22D3.2f.1
F22D3.2g.1
F22D3.2i.1
F22D3.2j.1
Other_sequence (21)
Associated_feature (63)
Experimental_infoRNAi_resultWBRNAi00013748Inferred_automaticallyRNAi_primary
WBRNAi00045306Inferred_automaticallyRNAi_primary
WBRNAi00013747Inferred_automaticallyRNAi_primary
WBRNAi00031265Inferred_automaticallyRNAi_primary
WBRNAi00092437Inferred_automaticallyRNAi_primary
WBRNAi00092428Inferred_automaticallyRNAi_primary
Expr_patternExpr10985
Expr13864
Expr1017397
Expr1037596
Expr1149230
Expr2011814
Expr2030052
Drives_constructWBCnstr00017598
WBCnstr00017614
WBCnstr00027093
Construct_productWBCnstr00017614
WBCnstr00027093
WBCnstr00040219
Regulate_expr_clusterWBPaper00042236:flcn-1(ok975)_upregulated
WBPaper00056471:flcn-1(ok975)_downregulated
WBPaper00056471:flcn-1(ok975)_upregulated
AntibodyWBAntibody00002522
Microarray_results (41)
Expression_cluster (164)
InteractionWBInteraction000402369
WBInteraction000520210
WBInteraction000520211
WBInteraction000520212
WBInteraction000520213
WBInteraction000520218
WBInteraction000521811
WBInteraction000534849
Map_infoMapIIPosition0.145905
PositivePositive_cloneF22D3Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00038491
WBPaper00042236
WBPaper00043118
WBPaper00048129
WBPaper00048631
WBPaper00049821
WBPaper00051847
WBPaper00055071
WBPaper00055090
WBPaper00061202
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene